Artículos de revistas
Hepatic Involvement In Paediatric Patients With Paracoccidioidomycosis: A Histological Study
Registro en:
Histopathology. , v. 64, n. 2, p. 256 - 262, 2014.
3090167
10.1111/his.12244
2-s2.0-84890158659
Autor
de Melo Braga G.
Hessel G.
Pereira R.M.
Escanhoela C.A.F.
Institución
Resumen
Aim: Paracoccidioidomycosis is a systemic mycosis that is endemic to certain countries in Latin America. This study aimed to describe the histological features of liver involvement in patients with paracoccidioidomycosis aged <16 years of age who were treated between 1980 and 2010, with a diagnosis that was confirmed by detection of the fungus by pathological examination. Methods and results: Liver tissue was obtained from one necropsy and 12 biopsies. Throughout 2007, biopsies were taken from patients with persistent jaundice or portal hypertension, after which biopsies became indicated due to elevated aminotransferase and low albumin levels. Using haematoxylin and eosin (H&E), Masson's trichrome and immunohistochemical (CK7 and CK19) staining, we noted degenerative alterations in bile duct cells and inflammatory injury to the bile ducts in 10 biopsies. Using immunohistochemistry for CK7 and CK19, we observed ductal proliferation in all 12 samples. 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