Artículos de revistas
Nat2, Xrcc1 And Hogg1 Polymorphisms, Cigarette Smoking, Alcohol Consumption And Risk Of Upper Aerodigestive Tract Cancer
Registro en:
Anticancer Research. International Institute Of Anticancer Research, v. 34, n. 6, p. 3217 - 3224, 2014.
2507005
2-s2.0-84906322745
Autor
Marques C.R.
Da Silva T.M.
De Albuquerque D.M.
Chaves M.S.
Filho M.F.M.
Oliveira J.S.
Di Pietro G.
Sousa S.M.B.
Simos A.L.
Rios-Santos F.
Institución
Resumen
Aim: To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair crosscomplementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. Patients and Methods: A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Results: Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among neverdrinkers (p=0.048). 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