Artículos de revistas
Olfactory Dysfunction In Parkinson's Disease [alterações Do Olfato Na Doença De Parkinson]
Registro en:
Arquivos De Neuro-psiquiatria. , v. 65, n. 03:00:00, p. 647 - 652, 2007.
0004282X
2-s2.0-34548846930
Autor
Quagliato L.B.
Viana M.A.
Quagliato E.M.A.B.
Simis S.
Institución
Resumen
Objective: To characterize the olfactory dysfunction in 50 Parkinson's disease (PD) patients with the University of Pennsylvania 12 smell identification test (UPSIT), establishing a comparison with 76 age-matched healthy controls, and associate with clinical and epidemiologic picture. Method: The PD group was evaluated in phase "on" through United Parkinson's disease rating scale, UPSIT, and Hoehn and Yahr stage and the control group with the UPSIT. Results: The mean UPSIT score was 5.7 in PD patients and 9 in the control group. Patients that presented initially resting tremor and those that currently have tremor, rigidity and bradykinesia had a significant lower scores. There were negative correlation between patients' age and PD stage with the UPSIT scores. There were no correlation between olfactory scores, age at the initial PD symptoms and disease duration. Conclusion: Among PD patients 80% had olfactory deficit and, therefore, smell evaluation may be a tool to make PD differential diagnosis. 65 03:00:00 647 652 Doty, R.J., Bromley, S.M., Stern, M.B., Olfactory testing as an aid in the diagnosis of Parkinson's disease: Development of optimal discrimination criteria (1995) Neurodegeneration, 4, pp. 93-97 Katzenschlager, R., Lees, A.J., Olfaction and Parkinson's syndromes: Its role in differential diagnosis (2004) Curr Opin Neurol, 17, pp. 417-423 Ponsen, M.M., Stoffers, D., Booij, J., Van Eck-Smit, B.L., Wolters, E.C.H., Berendse, H.W., Idiopathic hyposmia as a preclinical sign of Parkinson's disease (2004) Ann Neurol, 56, pp. 173-181 Siderowf, A., Newberg, A., Chou, H.L., 99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease (2005) Neurology, 64, pp. 1716-1720 Stiasny-Kolster, K., Doerr, Y., Moller, J.C., Combination of "idiopathic" REM sleep behavior disorder and olfactory dysfunction as possible indicator for alpha-syucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT (2005) Brain, 128, pp. 126-137 Berendse, H.W., Ponsen, M.M., Detection of preclinical Parkinson s disease along the olfactory tract (2006) J Neural Transm, 70 (SUPPL.), pp. S321-S325 Busenbark, K.L., Huber, S.J., Greer, G., Pahwa, R., Koller, W.C., Olfaction function in essential tremor (1992) Neurology, 42, pp. 1631-1632 Braak, H., Del Tredici, K., Bratzke, H., Hamm-Clement, J., Sandmann-Keil, D., Rub, U., Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) (2002) J Neurol, 249, pp. 1-5 Marras, C., Goldman, S., Smith, A., Smell identification ability in twin pairs discordant for Parkinson's disease.Mov Disord (2005), 20, pp. 687-693Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., Accuracy of clinical diagnosis of idiopathic Parkinson,s disease: A clinico-pathological study of 100 cases (1993) J Neurol Neurosurg Psychiatry, 55, pp. 181-184 Conover, W.J., (1971) Practical nonparametric statistics, , New York: John Wiley & Sons Inc Fleiss, J.L., (1981) Statistical methods for rates and proportions, , New York: 2.Ed. John Wiley & Sons Doty, R.L., Clinical studies of olfaction (2005) Chemical Senses, 30 (SUPPL. 1), pp. S207-S209 Raquelle, I., Mesholam, R.I., Moberg, P.J., Mah, R.N., Doty, R.L., Olfaction in neurodegenerative disease: A meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases (1998) Arch Neurol, 55, pp. 84-90 Braak, H., Tredici, K.D., Rub, U., de Vos, R.A.I., Steur, E.N.H.J., Braak, E., Staging of brain pathology related to sporadic Parkinson's disease (2003) Neurobiol Aging, 24, pp. 197-211 Braak, H., Ghebremedhin, E., Rub, U., Bratzke, H., Tredici, K.D., Stages in the development of Parkinson's disease-related pathology (2004) Cell Tissue Res, 318, pp. 121-134 Doty, R.L., Deems, D., Stellar, S., Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration (1988) Neurology, 38, pp. 1237-1244 Hawkes CH., Shephard BC, Daniel SE. Is Parkinson's disease a primary olfactory disorder? Q J Med 1999;92:473-480Postuma, R.B., Lang, A.E., Massicotte-Marquez, J., Montplaisir, J., Potential early markers of Parkinson's disease in idiopathic REM sleep behavior disorder (2006) Neurology, 66, pp. 845-851 Priyadarshi, A., Khuder, S.A., Schaub, E.A., Priyadarshi, S.S., Environmental risk factors and Parkinson's disease: A metaanalysis (2001) Environ Res, 86, pp. 122-127 Wright, J.M., Keller-Byrne, J., Environmental determinants of Parkinson's disease (2005) Arch Environ Occup Health, 60, pp. 32-38 Becker, G., Muller, A., Braune, S., Early diagnosis of Parkinson's disease (2002) J Neurol, 249 (SUPPL. 3), pp. S40-S48 Harding, A.J., Stimson, E., Henderson, J.M., Halliday, G.M., Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease (2002) Brain, 125, pp. 2431-2445