Artículos de revistas
Characterisation Of A New Splice Variant Of Mask-bp3arf And Mask Human Genes, And Their Expression Patterns During Haematopoietic Cell Differentiation
Registro en:
Gene. , v. 363, n. 1-2, p. 113 - 122, 2005.
3781119
10.1016/j.gene.2005.08.002
2-s2.0-28044441879
Autor
Duarte A.D.S.S.
Traina F.
Favaro P.M.B.
Basseres D.S.
De Carvalho I.C.
Medina S.D.S.
Costa F.F.
Saad S.T.O.
Institución
Resumen
In this study we report the characterisation of a new splice variant, here denominated splice variant 4 (accession number AF258557) of the human Multiple Ankyrin repeats Single KH domain (hMASK) (accession number AF521882) and the hMASK-4E-Binding Protein 3 Alternative Reading Frame (hMASK-BP3ARF) (accession number AF521883), containing a number of ANK-repeat motifs. Ankyrin (ANK) repeat-containing proteins carry out a wide variety of biological activities and are involved in processes, such as cell differentiation and transcriptional regulation. The present study reports the computer analysis of these splice variant cDNAs and their broad mRNA expression in different normal human tissues and cancer cell lines. An upregulation of the splice variant mRNAs expression was observed after HL-60 and erythroblast differentiation. The upregulation of splice variant 4 mRNA was considerably higher than those of the other variants, during erythroid differentiation. © 2005 Elsevier B.V. All rights reserved. 363 1-2 113 122 Bork, P., Hundreds of ankyrin-like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally? (1993) Proteins, 17, pp. 363-374 Brezinova, J., Zemanova, Z., Cermak, J., Michalova, K., Fluorescence in situ hybridization confirmation of 5q deletions in patients with hematological malignancies (2000) Cancer Genet. Cytogenet., 117, pp. 45-49 Cooper, T.A., Mattox, W., The regulation of splice-site selection, and its role in human disease (1997) Am. J. Hum. Genet., 61, pp. 259-266 Dias Neto, E., Shotgun sequencing of the human transcriptome with ORF expressed sequence tags (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 3491-3496 Fibach, E., Manor, D., Oppenheim, A., Rachmilewitz, E.A., Proliferation and maturation of human erythroid progenitors in liquid culture (1989) Blood, 73, pp. 100-103 Florea, L., Hartzell, G., Zhang, Z., Rubin, G.M., Miller, W., A computer program for aligning a cDNA sequence with a genomic DNA sequence (1998) Genome Res., 8, pp. 967-974 Gibson, T.J., Thompson, J.D., Heringa, J., The KH domain occurs in a diverse set of RNA-binding proteins that include the antiterminator NusA and is probably involved in binding to nucleic acid (1993) FEBS Lett., 324, pp. 361-366 Knutsen, T., Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification (2003) Genes Chromosomes Cancer, 37, pp. 270-281 Legendre, M., Gautheret, D., Sequence determinants in human polyadenylation site selection (2003) BMC Genomics, 4, p. 7 Michaely, P., Bennett, V., The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats (1993) J. Biol. Chem., 268, pp. 22703-22709 Michaely, P., Bennett, V., Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3-anion exchanger (1995) J. Biol. Chem., 270, pp. 31298-31302 Poulin, F., Brueschke, A., Sonenberg, N., Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK (2003) J. Biol. Chem., 278, pp. 52290-52297 Santos Duarte Ada, S., Sales, T.S., Mengel, J.O., Costa, F.F., Saad, S.T., Progesterone upregulates GATA-1 on erythroid progenitors cells in liquid culture (2002) Blood Cells Mol. Diseases, 29, pp. 213-224 Sedgwick, S.G., Smerdon, S.J., The ankyrin repeat: A diversity of interactions on a common structural framework (1999) Trends Biochem. Sci., 24, pp. 311-316 Siomi, H., Matunis, M.J., Michael, W.M., Dreyfuss, G., The pre-mRNA binding K protein contains a novel evolutionarily conserved motif (1993) Nucleic Acids Res., 21, pp. 1193-1198 Smith, R.K., Carroll, P.M., Allard, J.D., Simon, M.A., MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling (2002) Development, 129, pp. 71-82 Stamm, S., Function of alternative splicing (2005) Gene, 344, pp. 1-20 Tabaska, J.E., Zhang, M.Q., Detection of polyadenylation signals in human DNA sequences (1999) Gene, 231, pp. 77-86