Artículos de revistas
Characterization Of The Acute Pancreatitis Induced By Secretory Phospholipases A2 In Rats
Registro en:
Toxicon. , v. 46, n. 8, p. 921 - 926, 2005.
410101
10.1016/j.toxicon.2005.09.001
2-s2.0-28444483898
Autor
Camargo E.A.
Esquisatto L.C.M.
Esquisatto M.A.
Ribela M.T.C.P.
Cintra A.C.
Giglio J.R.
Antunes E.
Landucci E.C.T.
Institución
Resumen
Acute pancreatitis (AP) is an inflammatory disease of the pancreas characterized by local inflammation and extrapancreatic effects such as lung injury. Secretory phospholipases A2 (PLA2s) have been implicated in triggering AP, but their exact role to evoke AP is largely unknown. Therefore, we have tested the ability of sPLA2s to induce AP in rats, using venom sPLA2s with residual or high enzymatic activity (bothropstoxin-II and Naja mocambique mocambique venom PLA2, respectively), as well as sPLA2 devoid of catalytic activity (piratoxin-I). The injection of Naja m. mocambique venom PLA2, bothropstoxin-II or piratoxin-I (300 μg/kg each) into the common bile duct increased significantly the pancreatic plasma extravasation and myeloperoxidase activity. 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