Artículos de revistas
Homa1-ir And Homa2-ir Indexes In Identifying Insulin Resistance And Metabolic Syndrome - Brazilian Metabolic Syndrome Study (brams) [Índices Homa1-ir E Homa2-ir Para Identificação De Resistência à Insulina E Síndrome Metabólica - Estudo Brasileiro De Síndrome Metabólica (brams)]
Registro en:
Arquivos Brasileiros De Endocrinologia E Metabologia. , v. 53, n. 2, p. 281 - 287, 2009.
42730
2-s2.0-67649409016
Autor
Geloneze B.
Vasques A.C.J.
Stabe C.F.C.
Pareja J.C.
de Lima Rosado L.E.F.P.
de Queiroz E.C.
Tambascia M.A.
Institución
Resumen
Objective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p<0.001). The cut-off values for IR were: HOMA1-IR >2.7 and HOMA2-IR>1.8; and, for MS were: HOMA1-IR>2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR>1.4 (sensitivity: 79.2%; specificity: 61.2%). Conclusions: The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations. 53 2 281 287 Wilson, P.W., D'Agostino, R.B., Parise, H., Sullivan, L., Meigs, J.B., Met Syn as a precursor of cardiovascular disease and type 2 diabetes mellitus (2005) Circulation, 112 (20), pp. 3066-3072 Ezenwakan, C.E., Kalloo, R., Indices of obesity, dyslipidemia, and insulin resistance in apparently healthy Caribbean subjects (2003) J Clin Lab Anal, 17 (1), pp. 6-11 Conus, F., Allison, D.B., Rabasa-Lhoret, R., St-Onge, M., St-Pierre, D.H., Tremblay-Lebeau, A., Metabolic and behavioral characteristics of metabolically obese but normal-weight women (2004) J Clin Endocrinol Metab, 89 (10), pp. 5013-5020 Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28 (7), pp. 412-419 Levy, J.C., Matthews, D.R., Hermans, M.P., Correct homeostasis model assessment (HOMA) evaluation uses the computer program (1998) Diabetes Care, 21 (12), pp. 2191-2192 Geloneze, B., Repetto, E.M., Geloneze, S.R., Tambascia, M.A., Ermetice, M.N., The threshold value for insulin resistance (HOMA-IR) in an admixtured population IR in the Brazilian Metabolic Syndrome Study (2006) Diabetes Res Clin Prac, 72 (2), pp. 219-220 Wallace, T.M., Levy, J.C., Matthews, D.R., Use and abuse of HOMA modeling (2004) Diabetes Care, 27 (6), pp. 1487-1495 Alberti, K.G., Zimmet, P., Shaw, J., Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation (2006) Diabet Med, 23 (5), pp. 469-480 Oliveira, E.P., Souza, M.L.A., Lima, M.D.A., Prevalência de syndrome metabólica em uma área rural do semi-árido baiano (2006) Arq Bras Endocrinol Metab, 50 (3), pp. 456-465 Salaroli, L.B., Barbosa, G.C., Mill, J.G., Molina, M.C.B., Prevalência de síndrome metabólica em estudo de base populacional, Vitória, ES, Brasil (2007) Arq Bras Endocrinol Metab, 51 (7), pp. 1143-1152 Velásquez-Meléndez, G., Gazzinelli, A., Côrrea-Oliveira, R., Pimenta, A.M., Kac, G., Prevalence of metabolic syndrome in a rural area of Brazil (2007) Sao Paulo Med J, 125 (3), pp. 155-162 (2000) Obesity: Preventing and Managing the Global Epidemic, , World Health Organization, Report of a WHO Consultation, Geneva: World Health Organization V Diretrizes Brasileiras de Hipertensão Arterial (2007) Arq Bras Cardiol, 89 (3), pp. 24-79. , Sociedade Brasileira de Cardiologia Sociedade Brasileira de Hipertensão Sociedade Brasileira de Nefrolo Friedwald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge (1972) Clin Chem, 18 (6), pp. 499-502 Endocrinology & Metabolism (2009) HOMA Calculator, , http://www.dtu.ox.ac.uk/, The Oxford Centre for Diabetes, Diabetes Trial Unit, Available from, Acessed March Hanley, J.A., McNeil, B.J., A method of comparing the areas under receiver operating characteristic curves derived from the same cases (1983) Radiology, 148 (3), pp. 839-843 van der Schouw, Y.T., Verbeek, A.L., Ruijs, J.H., ROC curves for the initial assessment of new diagnostic tests (1992) Fam Pract, 9 (4), pp. 506-511 Buccini, G.S., Wolfthal, D.L., Valores de corte para índices de insulinorresistencia, insulinosensibilidad e insulinosecreción derivados de la fórmula HOMA y del programa HOMA2. Interpretación de los datos (2008) Rev Argent Endocrinol Metab, 45 (1), pp. 3-21 Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F., Egger, G., Targher, G., (1998) Prevalence of Insulin Resistance in Metabolic Disorders: The Bruneck Study Diabetes, 47 (10), pp. 1643-1649 Yeni-Komshian, H., Carantoni, M., Abbasi, F., Reaven, G.M., Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers (2000) Diabetes Care, 23 (2), pp. 171-175 Ascaso, J.F., Romero, P., Real, J.T., Priego, A., Valdecabres, C., Carmena, R., Cuantificación de insulinoresistencia con los valores de insulina basal e índice HOMA en una población no diabética (2001) Med Clin, 117 (x), pp. 530-533 Lee, S., Choi, S., Kim, H.J., Chung, Y.S., Lee, K.W., Lee, H.C., Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults (2006) J Korean Med Sci, 21 (4), pp. 695-700 Madeira, I.R., Carvalho, C.N.M., Gazolla, F.M., Matos, H.J., Borges, M.A., Bordallo, M.A.N., Ponto de corte do Índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) avaliado pela curva Receiver Operating Characteristic (ROC) na detecção de síndrome metabólica em crianças pré-púberes com excesso de peso (2008) Arq Bras Endocrinol Metab, 52 (9), pp. 1466-1473 Reaven, G.M., Insulin resistance: The link between obesity and cardiovascular disease (2008) Endocrinol Metab Clin North Am, 37 (3), pp. 581-601 McLaughlin, T., Allison, G., Abbasi, F., Lamendola, C., Reaven, G., Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals (2004) Metabolism, 53 (4), pp. 495-499 Pouliot, M.C., Després, J.P., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women (1994) Am J Cardiol, 73 (7), pp. 460-468