Artículos de revistas
Drug Interactions In Female Oncologic Inpatients: Differences Among Databases [interações Medicamentosas Em Mulheres Internadas Com Câncer: Diferenças Entre Bases De Dados]
Registro en:
Revista De Ciencias Farmaceuticas Basica E Aplicada. , v. 34, n. 3, p. 333 - 337, 2013.
18084532
2-s2.0-84887557037
Autor
Moriel P.
Siqueira J.A.
Carnevale R.C.
Rezende Costa C.G.
da Cruz A.A.
da Silva N.M.O.
Bernardes A.C.
Carvalho R.P.
Mazzola P.G.
Institución
Resumen
The aim of the present study was to quantify drug interactions in prescriptions for women undergoing supportive therapy in an oncology setting at a women's hospital in Brazil and compare the information provided by different databases regarding these drug interactions. A convenience sample was selected of prescriptions for patients diagnosed with breast or gynecological tumors hospitalized in the clinical oncology and surgery wards from April to June 2009. DRUGDEX/Micromedex (Thomson Micromedex) was the main database used for the identification of drug interactions and was compared with two other databases: Drugs.com and Lexicomp. The search was performed by inputting all drug combinations found in the prescriptions in Micromedex and Drugs.com. All interactions identified and classified by Micromedex and/or Drugs.com as of major severity were then checked in Lexicomp. A total of 152 interactions were identified by Micromedex (61 major, 69 moderate and 22 minor). In Drugs.com, 614 interactions were identified (85 major, 464 moderate and 65 minor). Forty-four were classified as major drug interactions in at least one of the databases: 30 in Micromedex, 26 in Drugs. com and 14 in Lexicomp. The present findings reveal discrepancies among the three databases analyzed. Thus, standardization should be proposed. Moreover, both the pharmacist and multidisciplinary team should perform a critical analysis of prescriptions to promote safe practices in the use of medications and minimize potential complications caused by drug interactions. 34 3 333 337 Aronson, J.K., Medication errors: What they are, how they happen, and how to avoid them (2009) QJM, 102 (8), pp. 513-521 Barrons, R., Evaluation of personal digital assistant software for drug interactions (2004) Am J Health Syst Pharm, 61 (4), pp. 380-385 Baxter, K., (2008) Stockley's Drug Interactions, , 8th ed. Chicago: Pharmaceutical Press Brunton, L.L., Lazo, J.S., Parker, K.L., (2006) Goodman & Gilman: As Bases Farmacológicas Da Terapêutica, , editors, 11th ed. Rio de Janeiro: McGraw-Hill Interamericana do Brasil Calop, J., Limat, S., Fernandez, C., (2008) Pharmacie Clinique Et Thérapeutique, , 3th ed. Paris: Elsevier Masson (2012), http://www.drugs.com/drug_interactions.html, Drug Information OnlineTM [Internet], [cited 2012 Apr. 16]. Available fromDean, B., Schachter, M., Vincent, C., Barber, N., Prescribing errors in hospital inpatients: Their incidence and clinical significance (2002) Qual Saf Health Care, 11 (4), pp. 340-344 Fish, J., Drug-drug interactions (2007) JPSW, 3, pp. 16-25 Fulda, T.R., Valuck, R.J., Zanden, J.V., Parker, S., Byrns, P., Disagreement Among Drug Compendia on Inclusion and Ratings of Drug-Drug Interactions (2000) Curr Ther Res Clin Exp, 61 (8), pp. 540-548 Gray, M.D., Felkey, B.G., Computerized prescriber order-entry systems: Evaluation, selection, and implementation (2004) Am J Health Syst Pharm, 61 (2), pp. 190-197 Kaboli, P.J., Hoth, A.B., McClimon, B.J., Schnipper, J.L., Clinical pharmacists and inpatient medical care: A systematic review (2006) Arch Intern Med, 166 (9), pp. 955-964 Karas, S., The potential for drug interactions (1981) Ann Emerg Med, 10 (12), pp. 627-630 Lacy, C.F., Armstrong, L.L., Goldman, M.P., Lance, L.L., (2009) Drug Information Handbook, , 17th ed. Hudson: LexiComp Inc (2012), http://www.thomsonhc.com, Micromedex® Healthcare Series [Internet], [cited 2012 Apr.16]. Available fromMoura, C.S., Acurcio, F.A., Belo, N.O., Drug-drug interactions associated with length of stay and cost of hospitalization (2009) J Pharm Pharm Sci, 12 (3), pp. 266-272 Reimche, L., Forster, A.J., van Walraven, C., Incidence and contributors to potential drug-drug interactions in hospitalized patients (2011) J Clin Pharmacol, 51 (7), pp. 1043-1050 Reis, A.M.M., Cassiani, S.H.D.B., Evaluation of three brands of drug interaction software for use in intensive care units (2010) Pharm World Sci, 32 (6), pp. 822-828 Seymour, R., Routledge, P., Important drug-drug interactions in the elderly (1998) Drugs Aging, 12 (6), pp. 485-494 Vitry, A.I., Comparative assessment of four drug interaction compendia (2007) Br J Clin Pharmacol, 63 (6), pp. 709-714 Vonbach, P., Dubied, A., Beer, J.H., Krähenbühl, S., Recognition and management of potential drug-drug interactions in patients on internal medicine wards (2007) Eur J Clin Pharmacol, 63 (11), pp. 1075-1083 Vonbach, P., Dubied, A., Krähenbühl, S., Beer, J.H., Evaluation of frequently used drug interaction screening programs (2008) Pharm World Sci, 30 (4), pp. 367-374 Wóron, J., Filipczak-Bryniarska, I., Wordliczek, J., Undesirable drug interaction in palliative medicine (2008) Advances In Palliative Medicine, 7 (2), pp. 81-88