Artículos de revistas
Vitamin D3 Induces Ido+ Tolerogenic Dcs And Enhances Treg, Reducing The Severity Of Eae
Registro en:
Cns Neuroscience And Therapeutics. , v. 19, n. 4, p. 269 - 277, 2013.
17555930
10.1111/cns.12071
2-s2.0-84875616786
Autor
Farias A.S.
Spagnol G.S.
Bordeaux-Rego P.
Oliveira C.O.F.
Fontana A.G.M.
de Paula R.F.O.
Santos M.P.A.
Pradella F.
Moraes A.S.
Oliveira E.C.
Longhini A.L.F.
Rezende A.C.S.
Vaisberg M.W.
Santos L.M.B.
Institución
Resumen
Background: A growing body of evidence supports the hypothesis that vitamin D is an important environmental factor in the etiology of T-cell-mediated autoimmune diseases such as multiple sclerosis (MS). Aim: The purpose of this study was exploring the mechanisms underlying the beneficial effect of vitamin D3 in encephalomyelitis (EAE). Methods: We treated monophasic experimental autoimmune EAE, induced in Lewis rat, with vitamin D3 and adoptively transfer tolerogenic bone marrow-derived DCs generated in the presence of vitamin D3. Results: This study provides evidence that the in vivo administration of vitamin D3, as well as the adoptive transfer of vitamin D3-induced IDO+ immature/tolerogenic dendritic cells, leads to a significant increase in the percentage of CD4+CD25+Foxp3+ regulatory T cells in the lymph nodes in a rat model of MS, experimental autoimmune EAE. Concomitant with the increase in this cell population, there is a significant decrease in the number of autoreactive T cells in the central nervous system. Bone marrow-derived DCs cultivated in the presence of vitamin D3 present a tolerogenic profile with high IL-10, TNFα, and IDO expression and decreased MHC-II and CD80 expression. The adoptive transfer of IDO + DCs induces a significant increase in the percentage of CD4+CD25+Foxp3+ T cells in the lymph nodes, comparable with vitamin D3 treatment. Conclusion: These mechanisms contribute actively to the generation of a microenvironment in the lymph nodes that suppresses the activation of encephalitogenic T cells, resulting in the downregulation of the inflammatory response in the central nervous system. © 2013 Blackwell Publishing Ltd. 19 4 269 277 Hafler, D.A., Slavik, J.M., Anderson, D.E., O'Connor, K.C., De Jager, P., Baecher-Allan, C., Multiple sclerosis (2005) Immunol Rev, 204, pp. 208-231 van der Mei, I.A., Ponsonby, A.L., Blizzard, L., Dwyer, T., Regional variation in multiple sclerosis prevalence in Australia and its association with ambient ultraviolet radiation (2001) Neuroepidemiology, 20, pp. 168-174 Wallin, M.T., Page, W.F., Kurtzke, J.F., Multiple sclerosis in US veterans of the Vietnam era and later military service: Race, sex, and geography (2004) Ann Neurol, 55, pp. 65-71 Cantorna, M.T., Hayes, C.E., DeLuca, H.F., 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis (1996) Proc Natl Acad Sci U S A, 93, pp. 7861-7864 Spach, K.M., Hayes, C.E., Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice (2005) J Immunol, 175, pp. 4119-4126 Becklund, B.R., Hansen Jr, D.W., Deluca, H.F., Enhancement of 1,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis by calcitonin (2009) Proc Natl Acad Sci U S A, 106, pp. 5276-5281 Santos, L.M., al-Sabbagh, A., Londono, A., Weiner, H.L., Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice (1994) Cell Immunol, 157, pp. 439-447 Hou, S.W., Liu, C.Y., Li, Y.H., Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect (2012) CNS Neurosci Ther, 18, pp. 909-917 Spach, K.M., Nashold, F.E., Dittel, B.N., Hayes, C.E., IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis (2006) J Immunol, 177, pp. 6030-6037 Bettelli, E., Carrier, Y., Gao, W., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells (2006) Nature, 441, pp. 235-238 Langrish, C.L., Chen, Y., Blumenschein, W.M., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005) J Exp Med, 201, pp. 233-240 Park, H., Li, Z., Yang, X.O., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005) Nat Immunol, 6, pp. 1133-1141 O'Connor, R.A., Prendergast, C.T., Sabatos, C.A., Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis (2008) J Immunol, 181, pp. 3750-3754 Muthian, G., Raikwar, H.P., Rajasingh, J., Bright, J.J., 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis (2006) J Neurosci Res, 83, pp. 1299-1309 Tang, J., Zhou, R., Luger, D., Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response (2009) J Immunol, 182, pp. 4624-4632 Adorini, L., Penna, G., Dendritic cell tolerogenicity: A key mechanism in immunomodulation by vitamin D receptor agonists (2009) Hum Immunol, 70, pp. 345-352 Mora, J.R., Iwata, M., von Andrian, U.H., Vitamin effects on the immune system: Vitamins A and D take centre stage (2008) Nat Rev Immunol, 8, pp. 685-698 Hewison, M., Freeman, L., Hughes, S.V., Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells (2003) J Immunol, 170, pp. 5382-5390 Piemonti, L., Monti, P., Sironi, M., Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells (2000) J Immunol, 164, pp. 4443-4451 Szeles, L., Keresztes, G., Torocsik, D., 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype (2009) J Immunol, 182, pp. 2074-2083 Correale, J., Ysrraelit, M.C., Gaitan, M.I., Vitamin D-mediated immune regulation in multiple sclerosis (2011) J Neurol Sci, 311, pp. 23-31 Tang, Q., Bluestone, J.A., The Foxp3 + regulatory T cell: A jack of all trades, master of regulation (2008) Nat Immunol, 9, pp. 239-244 Awasthi, A., Carrier, Y., Peron, J.P., A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells (2007) Nat Immunol, 8, pp. 1380-1389 Carrier, Y., Yuan, J., Kuchroo, V.K., Weiner, H.L., Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity (2007) J Immunol, 178, pp. 172-178 Sakaguchi, S., Ono, M., Setoguchi, R., Foxp3 + CD25 + CD4 + natural regulatory T cells in dominant self-tolerance and autoimmune disease (2006) Immunol Rev, 212, pp. 8-27 Anderton, S.M., Liblau, R.S., Regulatory T cells in the control of inflammatory demyelinating diseases of the central nervous system (2008) Curr Opin Neurol, 21, pp. 248-254 O'Connor, R.A., Anderton, S.M., Foxp3 + regulatory T cells in the control of experimental CNS autoimmune disease (2008) J Neuroimmunol, 193, pp. 1-11 Awasthi, A., Murugaiyan, G., Kuchroo, V.K., Interplay between effector Th17 and regulatory T cells (2008) J Clin Immunol, 28, pp. 660-670 Barrat, F.J., Cua, D.J., Boonstra, A., In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines (2002) J Exp Med, 195, pp. 603-616 Ureta, G., Osorio, F., Morales, J., Rosemblatt, M., Bono, M.R., Fierro, J.A., Generation of dendritic cells with regulatory properties (2007) Transplant Proc, 39, pp. 633-637 Penna, G., Roncari, A., Amuchastegui, S., Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4(+)Foxp3(+) regulatory T cells by 1,25-dihydroxyvitamin D-3 (2005) Blood, 106, pp. 3490-3497 Farias, A.S., Martins-de-Souza, D., Guimaraes, L., Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis (2012) Proteomics, 12, pp. 2656-2662 Farias, A.S., Talaisys, R.L., Blanco, Y.C., Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis (2011) PLoS ONE, 6, pp. e17849 Ramsdell, F., Foxp3 and natural regulatory T cells: Key to a cell lineage? (2003) Immunity, 19, pp. 165-168 Sucher, R., Fischler, K., Oberhuber, R., IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival (2012) J Immunol, 188, pp. 37-46 O'Sullivan, B.J., Pai, S., Street, S., Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation (2011) J Immunol, 187, pp. 4018-4030 Sun, Y., Chin, Y.E., Weisiger, E., Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3 (2009) J Immunol, 182, pp. 5899-5903 Enioutina, E.Y., Bareyan, D., Daynes, R.A., Vitamin D3-mediated alterations to myeloid dendritic cell trafficking in vivo expand the scope of their antigen presenting properties (2007) Vaccine, 25, pp. 1236-1249 Pallotta, M.T., Orabona, C., Volpi, C., Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells (2011) Nat Immunol, 12, pp. 870-878 Steinbrink, K., Wolfl, M., Jonuleit, H., Knop, J., Enk, A.H., Induction of tolerance by IL-10-treated dendritic cells (1997) J Immunol, 159, pp. 4772-4780 Chen, W., IDO: More than an enzyme (2011) Nat Immunol, 12, pp. 809-811 Smolders, J., Peelen, E., Thewissen, M., The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis (2009) Autoimmun Rev, 8, pp. 621-626