Artículos de revistas
The Intrahippocampal Infusion Of Crotamine From Crotalus Durissus Terrificus Venom Enhances Memory Persistence In Rats
Registro en:
Toxicon. Elsevier Ltd, v. 85, n. , p. 52 - 58, 2014.
410101
10.1016/j.toxicon.2014.04.017
2-s2.0-84901276092
Autor
Vargas L.S.
Lara M.V.S.
Goncalves R.
Mandredini V.
Ponce-Soto L.A.
Marangoni S.
Dal Belo C.A.
Mello-Carpes P.B.
Institución
Resumen
Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory. © 2014 Elsevier Inc. All rights reserved. 85
52 58 Adriani, W., Felici, A., Sargolini, F., Roullet, P., Usiello, A., Oliverio, A., Mele, A., N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes (1998) Experimental Brain Research, 123 (1-2), pp. 52-59. , DOI 10.1007/s002210050544 Bekinschtein, P., Katche, C., Persistence of long-term memory storage: New insights into its molecular signatures in the hippocampus and related structures (2010) Neurotox. Res., 18 (34), pp. 377-385 Bengtson, C.P., Kaiser, M., Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons (2013) Biochim. Biophys. Acta, 1833 (7), pp. 1672-1679 Bonini, J.S., Bevilaqua, L.R., Zinn, C.G., Kerr, D.S., Medina, J.H., Izquierdo, I., Cammarota, M., Angiotensin II disrupts inhibitory avoidance memory retrieval (2006) Hormones and Behavior, 50 (2), pp. 308-313. , DOI 10.1016/j.yhbeh.2006.03.016, PII S0018506X06000894 Brazil, O.V., Fontana, M.D., Toxins as tools in the study of sodium channel distribution in the muscle fibre membrane (1993) Toxicon, 31 (9), pp. 1085-1098 Camillo, M.A.P., Arruda Paes, P.C., Troncone, L.R.P., Rogero, J.R., Gyroxin fails to modify in vitro release of labelled dopamine and acetylcholine from rat and mouse striatal tissue (2001) Toxicon, 39 (6), pp. 843-853. , DOI 10.1016/S0041-0101(00)00222-1, PII S0041010100002221 Chen, X., Yuan, L.-L., Zhao, C., Birnbaum, S.G., Frick, A., Jung, W.E., Schwarz, T.L., Johnston, D., Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons (2006) Journal of Neuroscience, 26 (47), pp. 12143-12151. , http://www.jneurosci.org/cgi/reprint/26/47/12143, DOI 10.1523/JNEUROSCI.2667-06.2006 Dal Belo, C.A., Lucho, A.P.B., In Vitro antiophidian mechanisms of Hypericum brasiliense choisy standardized extract: Quercetin-dependent neuroprotection (2013) Biomed. Res. Int., pp. 1-6. , ID 943520 Doralp, S., Leung, L.S., Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiation (2008) Neurobiol. Learn Mem., 90 (2), pp. 382-388 Ennaceur, A., Delacour, J., A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data (1988) Behav. Brain Res., 31 (1), pp. 47-59 Federman, N., De La Fuente, V., Nuclear factor kappaB-dependent histone acetylation is specifically involved in persistent forms of memory (2013) J. Neurosci., 33 (17), pp. 7603-7614 Ghelardini, C., Galeotti, N., Bartolini, A., Influence of potassium channel modulators on cognitive processes in mice (1998) British Journal of Pharmacology, 123 (6), pp. 1079-1084. , DOI 10.1038/sj.bjp.0701709 Gomes, G.M., Dalmolin, G.D., The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of naive and Abeta(25-35)-treated mice (2013) Toxicon, 76, pp. 23-27 Habermann, E., Cheng-Raude, D., Central neurotoxicity of apamin, crotamin, phospholipase A and alpha-amanitin (1975) Toxicon, 13 (6), pp. 465-473 Harooni, H.E., Naghdi, N., The role of hippocampal nitric oxide (NO) on learning and immediate, short- and long-term memory retrieval in inhibitory avoidance task in male adult rats (2009) Behav. Brain Res., 201 (1), pp. 166-172 Hernandez-Oliveira Silva, E.S., Rostelato-Ferreira, S., Beneficial effect of crotamine in the treatment of myasthenic rats (2013) Muscle Nerve, 47 (4), pp. 591-593 Hersi, A.I., Rowe, W., Gaudreau, P., Quirion, R., Dopamine D1 receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats (1995) Neuroscience, 69 (4), pp. 1067-1074. , DOI 10.1016/0306-4522(95)00319-E Hoffman, D.A., Magee, J.C., Colbert, C.M., Johnston, D., K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons (1997) Nature, 387 (6636), pp. 869-875. , DOI 10.1038/43119 Igaz, L.M., Vianna, M.R.M., Medina, J.H., Izquierdo, I., Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning (2002) Journal of Neuroscience, 22 (15), pp. 6781-6789 Jay, T.M., Dopamine: A potential substrate for synaptic plasticity and memory mechanisms (2003) Progress in Neurobiology, 69 (6), pp. 375-390. , DOI 10.1016/S0301-0082(03)00085-6 Johnstone, V.P., Raymond, C.R., Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation (2013) Front. Synaptic Neurosci., 5, p. 1 Kerkis, I., Silva, F.D.S., Biological versatility of crotamine - A cationic peptide from the venom of a South American rattlesnake (2010) Expert Opin. Investig. Drugs, 19 (12), pp. 1515-1525 Klinkenberg, I., Sambeth, A., Acetylcholine and attention (2011) Behav. Brain Res., 221 (2), pp. 430-442 Koh, D.C.I., Armugam, A., Jeyaseelan, K., Snake venom components and their applications in biomedicine (2006) Cellular and Molecular Life Sciences, 63 (24), pp. 3030-3041. , DOI 10.1007/s00018-006-6315-0 Kourrich, S., Manrique, C., (2005) Transient Hippocampal Down-Regulation of Kv1.1 Subunit MRNA during Associative Learning in Rats, 12, pp. 511-519. , Cold Spring Harbor Laboratory Press Minnesota Levin, E.D., Rose, J.E., Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance (1991) Pharmacol. Biochem. Behav., 38 (2), pp. 243-246 Lopes Aguiar, C., Romcy-Pereira, R.N., Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: A possible involvement of monoaminergic systems (2008) Neuroscience, 153 (4), pp. 1309-1319 Mancin, A.C., Soares, A.M., Andriao-Escarso, S.H., Faca, V.M., Greene, L.J., Zuccolotto, S., Pela, I.R., Giglio, J.R., The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: A biochemical and pharmacological study (1998) Toxicon, 36 (12), pp. 1927-1937. , DOI 10.1016/S0041-0101(98)00117-2, PII S0041010198001172 Matavel, A.C.S., Ferreira-Alves, D.L., Beirao, P.S.L., Cruz, J.S., Tension generation and increase in voltage-activated Na+ current by crotamine (1998) European Journal of Pharmacology, 348 (2-3), pp. 167-173. , DOI 10.1016/S0014-2999(98)00152-6, PII S0014299998001526 Mello, L.E.A.M., Cavalheiro, E.A., Behavioural, electroencephalographic and neuropathological effects of the intrahippocampal injection of the venom of the South American rattlesnake (Crotalus durissus terrificus) (1989) Toxicon, 27 (2), pp. 189-199. , DOI 10.1016/0041-0101(89)90132-3 Myhrer, T., Neurotransmitter systems involved in learning and memory in the rat: A meta-analysis based on studies of four behavioral tasks (2003) Brain Research Reviews, 41 (2-3), pp. 268-287. , DOI 10.1016/S0165-0173(02)00268-0 Newman, E.L., Gupta, K., Cholinergic modulation of cognitive processing: Insights drawn from computational models (2012) Front. Behav. Neurosci., 6, p. 24 Ownby, C.L., Structure, function and biophysical aspects of the myotoxins from snake venoms (1998) Journal of Toxicology - Toxin Reviews, 17 (2), pp. 213-238 Paxinos, G., Watson, C., (1986) The Rat Brain in Stereotaxic Coordinates, , Academic Press San Diego Peigneur, S., Orts, D.J., Crotamine pharmacology revisited: Novel insights based on the inhibition of KV channels (2012) Mol. Pharmacol., 82 (1), pp. 90-96 Pellow, S., Chopin, P., File, S.E., Briley, M., Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat (1985) Journal of Neuroscience Methods, 14 (3), pp. 149-167. , DOI 10.1016/0165-0270(85)90031-7 Quevedo, J., Vianna, M.R.M., Roesler, R., De-Paris, F., Izquierdo, I., Rose, S.P.R., Two time windows of anisomycin-induced amnesia for inhibitory avoidance training in rats: Protection from amnesia by pretraining but not pre-exposure to the task apparatus (1999) Learning and Memory, 6 (6), pp. 600-607. , DOI 10.1101/lm.6.6.600 Robinson, L., Platt, B., Involvement of the cholinergic system in conditioning and perceptual memory (2011) Behav. Brain Res., 221 (2), pp. 443-465 Rossato, J.I., Bevilaqua, L.R., Dopamine controls persistence of long-term memory storage (2009) Science, 325 (5943), pp. 1017-1020 Rossato, J.I., Radiske, A., Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus (2013) Neurobiol. Learn. Mem., 106, pp. 66-70 Ruff, R.L., Lennon, V.A., End-plate voltage-gated sodium channels are lost in clinical and experimental myasthenia gravis (1998) Annals of Neurology, 43 (3), pp. 370-379. , DOI 10.1002/ana.410430315 Tjolsen, A., Lund, A., Berge, O.-G., Hole, K., An improved method for tail-flick testing with adjustment for tail-skin temperature (1989) Journal of Neuroscience Methods, 26 (3), pp. 259-265. , DOI 10.1016/0165-0270(89)90124-6 Wahlstrom, D., Collins, P., Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment (2010) Brain Cogn., 72 (1), pp. 146-159 Werenicz, A., Christoff, R.R., Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence (2012) Learn. Mem., 19 (10), pp. 495-498 Xu, Y., Yan, J., Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease (2012) Prog. Neurobiol., 97 (1), pp. 1-13