Artículos de revistas
Structural Brain Abnormalities Are Related To Retinal Nerve Fiber Layer Thinning And Disease Duration In Neuromyelitis Optica Spectrum Disorders
Registro en:
Multiple Sclerosis. Sage Publications Ltd, v. 20, n. 9, p. 1189 - 1197, 2014.
13524585
10.1177/1352458513519838
2-s2.0-84897935386
Autor
Von Glehn F.
Jarius S.
Cavalcanti Lira R.P.
Alves Ferreira M.C.
Von Glehn F.H.R.
Costa E Castro S.M.
Beltramini G.C.
Bergo F.P.
Farias A.S.
Brandao C.O.
Wildemann B.
Damasceno B.P.
Cendes F.
Santos L.M.B.
Yasuda C.L.
Institución
Resumen
Background: Although aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO. Objective: This study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness. Methods: Twenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed. Results: We demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease. Conclusions: Our findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. 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