Production Of The Anticancer Drug Taxol In Taxus Baccata Suspension Cultures: A Review

dc.creatorMalik S.
dc.creatorCusido R.M.
dc.creatorMirjalili M.H.
dc.creatorMoyano E.
dc.creatorPalazon J.
dc.creatorBonfill M.
dc.date2011
dc.date2015-06-30T20:43:38Z
dc.date2015-11-26T14:54:16Z
dc.date2015-06-30T20:43:38Z
dc.date2015-11-26T14:54:16Z
dc.date.accessioned2018-03-28T22:06:09Z
dc.date.available2018-03-28T22:06:09Z
dc.identifier
dc.identifierProcess Biochemistry. , v. 46, n. 1, p. 23 - 34, 2011.
dc.identifier13595113
dc.identifier10.1016/j.procbio.2010.09.004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78650254061&partnerID=40&md5=4e9abe0a8fd082f7bb1747432bba654b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/109009
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/109009
dc.identifier2-s2.0-78650254061
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255112
dc.descriptionPlant cell factories constitute an alternative source of high added value phytochemicals such as the anticancer drug taxol (generic name paclitaxel), biosynthesized in Taxus spp. The growing demand for taxol and its derivatives, due to a specific action mechanism and the scarcity of the taxane ring in nature, has made this group of compounds one of the most interesting targets for biotechnological production. This review is focused on recent advances in the production of taxol and related taxanes in Taxus baccata, the taxol-producing European yew, using cell suspension culture technology. The review contains a brief description of the botany and phytochemistry of T. baccata, as well as the chemical structure of taxol and the molecular requirements for its anticancer effects. After a short overview of taxol production at an industrial level, the review focuses on taxol biosynthesis in plant cells and the attempts to produce taxol in T. baccata cell cultures, giving particular emphasis to the optimization steps that have improved production, and including the most recently developed new tools. Finally, the future prospects for the biotechnological production of taxol are also discussed. © 2010 Elsevier Ltd. All rights reserved.
dc.description46
dc.description1
dc.description23
dc.description34
dc.descriptionAbella, I., (1996) La Magia de Los Árboles (Simbolismo, Mitos y Tradiciones, Plantación y Cuidados), , Ediciones Integral Barcelona
dc.descriptionCope, E.A., Taxaceae: The genera and cultivated species (1998) Bot Rev, 64, pp. 291-322
dc.descriptionWani, M., Taylor, H., Wall, M., Coggon, P., McPhail, A., Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia (1971) J Am Chem Soc, 93, pp. 2325-2327
dc.descriptionSchiff, P.B., Fant, J., Horwitz, S.B., Promotion of microtubule assembly in vitro by taxol (1979) Nat Biotechnol, pp. 665-667
dc.descriptionGuenard, D., Gueritte-Voegelein, F., Poiter, P., Taxol and taxotere: Discovery, chemistry and structure activity relationship (1993) Accounts Chem Res, 26, pp. 160-167
dc.descriptionGurbuz, I., Erdemoglu, N., Yesilada, E., Sener, B., Anti-ulcerogenic lignans from Taxus baccata L. (2004) Z-Naturforsch-[C], 59, pp. 233-236
dc.descriptionCho, J.Y., Park, J., Kim, P.S., Yoo, E.S., Baik, K.U., Park, M.H., Alignan from Pterocaroussantlinus inhibits tumor necrosis factor- alpha production and T cell proliferation (2001) Biol Pharm Bull, 24, pp. 167-171
dc.descriptionTopcu, G., Demirkiran, O., Lignans from Taxus species (2007) Topics Heterocyclic Chem, 11, pp. 103-114
dc.descriptionKüpeli, E., Erdemoglu, N., Yesilada, E., Sener, B., Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. (2003) J Ethnopharmacol, 89, pp. 265-270
dc.descriptionPanchagnula, R., Pharmaceutical aspects of paclitaxel (1998) Int J Pharmaceut, 72, pp. 1-15
dc.descriptionKingston, D.G.I., Recent advances in the chemistry of taxol (2000) J Nat Prod, 63, pp. 726-734
dc.descriptionHe, L., Jagtap, G.P., Kingston, D.G.I., Shen, H.J., Orr, G.A., Horwitz, S.B., A common pharmacophore for taxol and the epothilones based on the biological activity of taxane molecule lacking a C-13 side chain (2000) Biochemistry, 39, pp. 3972-3978
dc.descriptionYeung, T.K., Germond, C., Chen, X., Wang, Z., The mode of action of taxol: Apoptosis at low concentration and necrosis at high concentration (1999) Biochem Biophys Res Commun, 263, pp. 398-404
dc.descriptionKovács, P., Csaba, G., Pallinger, E., Czaker, R., Effects of taxol treatment on the microtubular system and mitochondria of Tetra hymena (2007) Cell Biol Int, 31, pp. 724-732
dc.descriptionSquibb, B.M., http://packageinserts.bms.com/pi/pi_taxol.pdf;2007Ehrlich, A., Booher, S., Becerra, Y., Borris, D.L., Figg, W.D., Turner, M.L., Micellar paclitaxel improves severe psoriasis in a prospective phase II pilot study (2004) J Am Acad Dermatol, 50, pp. 533-540
dc.descriptionZhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model (2005) Proc Natl Acad Sci USA, 102, pp. 227-231
dc.descriptionGeorg, G.I., Hurrumun, G.C.B., Ali, S.M., Datta, A., Hepperle, M., Synthesus of 2-O-heteroaroyl taxanes: Evaluation of microtubule assembly promotion and cytotoxicity (1995) Bioorg Med Chem Lett, 5, pp. 115-118
dc.descriptionWang, X., Itokawa, H., Lee, K.H., (2003) Taxus, the Genus Taxus, pp. 298-306
dc.descriptionEisenreich, W., Mewnhard, B., Hylands, P.J., Zenk, M.H., Bacher, A., Studies on the biosynthesis of taxol: The taxane carbon skeleton is not of mevalonoid origin (1996) Proc Natl Acad Sci USA, 93, pp. 6431-6436
dc.descriptionLansing, A., Haertel, M., Gordon, M., Floss, H.G., Biosynthetic studies on taxol (1991) Planta Med, 57, pp. 83-84
dc.descriptionExpósito, O., Bonfill, M., Onrubia, M., Jané, A., Moyano, E., Cusidó, R.M., Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures (2009) New Biotechnol, 25, pp. 252-259
dc.descriptionCusidó, R.M., Palazón, J., Bonfill, M., Expósito, O., Moyano, E., Piñol, M.T., Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata (2007) Biochem Eng J, 33, pp. 159-167
dc.descriptionZamir, L.O., Nedea, M., Belair, S., Sauriol, F., Mamer, O., Jacqmain, E., Rearrangement of the major taxane from Taxus canadensis (1992) Tetrahedron Lett, 33, pp. 5235-5236
dc.descriptionSrinivasan, V., Ciddi, V., Bringi, V., Shuler, M.L., Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures (1996) Biotechnol Progr, 12, pp. 457-465
dc.descriptionWang, Y.J., Yuan, M., Lu, J.C., Wu, Jiang, J.L., Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei (2003) Biotechnol Appl Bioc, 37, pp. 39-43
dc.descriptionHezari, M., Lewis, N.G., Croteau, R., Purification and characterization of taxa-4(5),11(12)-diene synthase from pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis (1995) Arch Biochem Biophys, 322, pp. 437-444
dc.descriptionWildung, M.R., Croteau, R.A., CDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis (1996) J Biol Chem, 271, pp. 9201-9204
dc.descriptionJennewein, S., Long, R.M., Williams, R.M., Croteau, R., Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis (2004) Chem Biol, 11, pp. 379-387
dc.descriptionHefner, J., Rubenstein, S.M., Ketchum, R.E.B., Gibson, D.M., Williams, R.M., Croteau, R., Cytochrome p450-catalyzed hydroxylation of taxa-4(5),11(12)-dien to taxa-4(20),11(12)-dien-alpha-ol. The first oxygenation step in taxol biosynthesis (1996) Chem Biol, 3, pp. 479-489
dc.descriptionWalker, K.D., Schoendorf, A., Croteau, R., Molecular cloning of taxa-4(20),11(12)-dien- 5alpha-ol-O-acetyl- transferase cDNA from Taxus and functional expresión in Escherichia coli (2000) Arch Biochem Biophys, 374, pp. 371-380
dc.descriptionSchoendorf, A., Rithner, C.D., Williams, R., Croteau, R.B., Molecular cloning of a cytochrome P450 taxane 10b-hydroxylase cDNA from Taxus and functional expresión in yeast (2001) Proc Natl Acad Sci USA, 98, pp. 1501-1506
dc.descriptionJennewein, S., Rithner, C.D., Williams, R.M., Croteau, R.B., Taxol biosíntesis: Taxaneb-hydroxylase is a citochrome P450-dependent monooxygenas (2001) Proc Natl Acad Sci USA, 98, pp. 13595-13600
dc.descriptionWheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M., Croteau, R., Taxol biosíntesis: Differential transformations of taxadien-alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspensión cells (2001) Arch Biochem Biophys, 390, pp. 265-278
dc.descriptionJennewein, S., Rithner, C.D., Williams, R.M., Croteau, R., Taxol metabolism: Taxoid 14b-hydroxylase is a cytochrome P450-dependent monooxygenase (2003) Arch Biochem Biophys, 413, pp. 262-270
dc.descriptionVongpaseuth, K., Roberts, S.C., Advancements in the understanding of Paclitaxel metabolism in tissue culture (2007) Curr Pharm Biotechnol, 8, pp. 219-236
dc.descriptionFloss, H.G., Mocek, U., Biosynthesis of taxol (1995) Taxol: Science and Applications, pp. 191-208
dc.descriptionWalker, K.Y., Croteau, R., Taxol biosynthesis: A review of some determinant steps (1999) Recent Adv Phytochem, 33, pp. 31-50
dc.descriptionJennewein, S., Croteau, R., Taxol: Biosynthesis, molecular genetics, and biotechnological applications (2001) Appl Microbiol Biot, 57, pp. 13-19
dc.descriptionCroteau, R.B., Ketchum, R.E.B., Long, R.M., Kaspera, R., Wildung, M.R., Taxol biosynthesis and molecular genetics (2006) Phytochem Rev, 5, pp. 75-97
dc.descriptionWalker, K., Klettke, K., Akiyama, T., Croteau, R.B., Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis (2004) J Biol Chem, 279, pp. 53947-53954
dc.descriptionWalker, K., Long, R., Croteau, R., The final acylation step in Taxol biosynthesis: Cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus (2002) Proc Natl Acad Sci USA, 99, pp. 9166-9171
dc.descriptionGanem, B., Franke, R.R., Paclitaxel from primary taxanes: A perspective on creative invention in organozirconium chemistry (2007) J Org Chem, 72, pp. 3981-3987
dc.descriptionSchippmann, U., (2001) Medicinal Plants Significant Trade Study (CITES Project S-109), , German Federal Agency for Nature Conservation Bonn Germany
dc.descriptionBedi, Y.S., Ogra, R.K., Koul, K., Kaul, B.L., Kapil, R.S., Yew (Taxus spp.). A new look on utilization, cultivation and conservation (1996) Supplement to Cultivation and Utilization of Medicinal Plants, pp. 443-456
dc.descriptionCameron, S., Smith, R., Seasonal changes in the concentration of major taxanes in the biomass of wild Canada Yew (Taxus canadensis Marsh) (2008) Pharm Biol, 46, pp. 35-40
dc.descriptionSmith, R.F., Cameron, S.I., Domesticating ground hemlock (Taxus canadensis) for producing taxanes: A case study (2002) Proceedings of 29th Annual Meeting of the Plant Growth Regulation Society of America, pp. 40-45
dc.descriptionHolton, R.A., Somoza, C., Kim, H.B., Liang, F., Biediger, R.J., Boatman, P.D., First total synthesis of taxol 1. Functionalization of the B ring (1994) J Am Chem Soc, 116, pp. 1597-1598
dc.descriptionHolton, R.A., Somoza, C., Kim, H.B., Liang, F., Biediger, R.J., Boatman, P.D., First total synthesis of taxol. 2. Completion of the C and D rings (1994) J Am Chem Soc, 116, pp. 1599-1600
dc.descriptionNicolau, K.C., Yang, Z., Liu, J.J., Total synthesis of taxol (1994) Nat Biotechnol, 367, pp. 630-634
dc.descriptionYuan, J., Jian-Nan, B., Bing, Y., Xu-Dong, Z., Taxol-producing fungi: A new approach to industrial production of taxol (2006) Chinese J Biotechnol, 22, pp. 1-6
dc.descriptionM, V.S., (1995) Taxol: Science and Applications, , CRC Press USA
dc.descriptionExpósito, O., Bonfill, M., Moyano, E., Onrubia, M., Mirjalili, M.H., Cusido, R.M., Biotechnological production of taxol and related taxoids: Current state and prospects (2009) Anti-Cancer Agents Med Chem, 9, pp. 109-121
dc.descriptionRohr, R., Production de cals par les gametophytes males de Taxus baccta L. cultivars sur un milieu artificiel. Etude en microscopie photonique et electronique (1973) Caryologia, 25, pp. 177-189
dc.descriptionRohr, R., Cytologie vegetale. Ultrastructure des spermatozoides de Taxus baccata L. obtenusa partir de cultures aseptiques de microspores sur un milieu artificiel (1973) CR Acad Sci Paris, 277, pp. 1869-1871
dc.descriptionDavid, A., Plasitra, V., Histophysiologie vegetale. Realisation de cultures de tissues d'If (Taxus baccata L.) a partir de fragments de pousses ages d'un an
dc.descriptionObtention d'une culture indefinie (1974) CR Acad Sci Paris, 279, pp. 1757-1759
dc.descriptionDavid, A., Plastira, V., Histophysiologie vegetale. Comportement en culture in vitro de cellules isolees de deux gymnospermes: Taxus baccata L. et Pinus pinaster Sol (1976) CR Acad Sci Paris, 110, pp. 5917-5919
dc.descriptionBrunakova, K., Babincova, Z., Takác, M., Cellárová, E., Selection of callus cultures of Taxus baccata L. as a potential source of paclitaxel production (2004) Eng Life Sci, 4, pp. 465-469
dc.descriptionWickremesinhe, E.R.M., Arteca, R.N., Taxus callus cultures: Initiation, growth optimization, characterization and taxol production (1993) Plant Cell Tiss Org, 35, pp. 181-193
dc.descriptionBrunakova, K., Babincova, Z., Cellárová, E., Production of taxanes in callus and suspension cultures of Taxus baccata L (2005) Liquid Culture Systems for in Vitro Plant Propagation, pp. 567-574
dc.descriptionGamborg, O.L., Miller, R.A., Ojima, K., Nutrient requirements of suspension cultures of soybean root cells (1968) Exp Cell Res, 50, pp. 151-158
dc.descriptionMurashige, T., Skoog, F., A revised medium for rapid growth and bioassays with tobacco tissue cultures (1962) Physiol Plantarum, 15, pp. 473-497
dc.descriptionSchenk, R.U., Hildebrandt, A.C., Medium and techniques for induction and growth of monocotyledonous and dicotyledonous plant cell cultures (1972) Can J Bot, 50, pp. 199-204
dc.descriptionMcCown, B.H., Lloyd, G., Woody Plant Medium (WPM) - A mineral nutrient formulation for microculture for woody plant species (1981) Hortic Sci, 16, p. 453
dc.descriptionMonacelli, B., Pasqua, G., Cuteri, A., Varusio, A., Botta, B., Delle Monache, G., Histological study of callus formation and optimization of cell growth in Taxus baccata (1995) Cytobios, 81, pp. 159-170
dc.descriptionDicosmo, F., Misawa, M., Plant cell and tissue culture: Alternatives for metabolite production (1995) Biotechnol Adv, 13, pp. 425-453
dc.descriptionStaba, E.J., Milestones in plant tissue culture systems for the production of secondary products (1985) J Nat Prod, 48, pp. 203-209
dc.descriptionRamachandra Rao, S., Ravishankar, G.A., Plant cell cultures: Chemical factories of secondary metabolites (2002) Biotechnol Adv, 20, pp. 101-153
dc.descriptionCusidó, R.M., Palazon, J., Navia-Osorio, A., Mallol, A., Bonfill, M., Morales, C., Production of Taxol® and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture (1999) Plant Sci, 146, pp. 101-107
dc.descriptionZhong, J.J., Plant cell culture for production of paclitaxel and other taxanes (2002) J Biosci Bioeng, 94, pp. 591-599
dc.descriptionKhosroushahi, A.Y., Valizadeh, M., Ghasempour, A., Khosrowshahli, M., Naghdibadi, H., Dadpour, M.R., Improved Taxol production by combination of inducing factors in suspension cell culture of Taxus baccata (2006) Cell Biol Int, 30, pp. 262-269
dc.descriptionFrense, D., Taxanes: Perspectives for biotechnological production (2007) Appl Microbiol Biot, 73, pp. 1233-1240
dc.descriptionJaziri, M., Zhiri, A., Guo, Y.W., Dupont, J.P., Shimomura, K., Hamada, H., Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: A literature survey (1996) Plant Cell Tiss Org, 46, pp. 59-75
dc.descriptionTabata, H., Production of paclitaxel and the related taxanes by cell suspension cultures of Taxus species (2006) Curr Drug Targets, 7, pp. 453-461
dc.descriptionMa, W., Park, G.L., Gomez, G.A., Nieder, M.H., Adams, T.L., Aynsley, J.S., New bioactive taxoids from cell cultures of Taxus baccata (1994) J Nat Prod, 57, pp. 116-122
dc.descriptionVaněk, T., Veselá, D., Malá, J., Podlipná, R., Šaman, D., Kohoutová, J., Production of taxanes by Taxus baccata plant cells (1996) Biotechnol Lett, 18, pp. 501-504
dc.descriptionLarkin, P.J., Scowcroft, W.R., Somaclonal variation - A novel source of variability from cell cultures for plant improvement (1981) Theor Appl Genet, 60, pp. 197-214
dc.descriptionBonfill, M., Expósito, O., Moyano, E., Cusidó, R.M., Palazon, J., Piñol, M.T., Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus baccata suspension cultures (2006) In Vitro Cell Dev-Pl, 42, pp. 422-426
dc.descriptionHirasuna, T.J., Pestchanker, L.J., Srinivasan, V., Shuler, M.L., Taxol production in suspension cultures of Taxus baccata (1996) Plant Cell Tiss Org, 44, pp. 95-102
dc.descriptionPalazón, J., Cusidó, R.M., Bonfill, M., Morales, C., Piñol, M.T., Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata (2003) J Biotechnol, 101, pp. 57-163
dc.descriptionNavia-Osorio, A., Garden, H., Cusidó, R.M., Palazón, J., Alfermann, A.W., Piñol, M.T., Taxol® and baccatin III production in suspension cultures of Taxus baccata and Taxus wallichiana in an airlift bioreactor (2002) J Plant Physiol, 159, pp. 97-102
dc.descriptionBentebibel, S., Moyano, E., Palazon, J., Cusido, R.M., Bonfill, M., Eibl, R., Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata (2005) Biotechnol Bioeng, 89, pp. 647-655
dc.descriptionMoon, W.J., Yoo, B.S., Kim, D.I., Byun, S.Y., Elicitation kinetics of taxane production in suspension cultures of Taxus baccata Pendula (1998) Biotechnol Tech., 12, pp. 79-81
dc.descriptionRadman, R., Saez, T., Bucke, C., Keshavarz, T., Elicitation of plants and microbial cell systems (2003) Biotechnol Appl Bioc, 37, pp. 91-102
dc.descriptionNamdeo, A.G., Plant cell elicitation for production of secondary metabolites: A review (2007) Pharmacog Rev, 1, pp. 69-79
dc.descriptionYukimune, Y., Tabata, H., Higashi, Y., Hara, Y., Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures (1996) Nat Biotechnol, 14, pp. 1129-1132
dc.descriptionWu, J., Wang, C., Mei, X., Stimulation of taxol production and excretion in Taxus spp. cell cultures by rare earth chemical lanthanum (2001) J Biotechnol, 85, pp. 67-73
dc.descriptionCiddi, V., Srinivasan, V., Shuler, M.L., Elicitation of Taxus sp. cell cultures for production of taxol (1995) Biotechnol Lett, 17, pp. 1343-1346
dc.descriptionFarmer, E.E., Ryan, C.A., Interplant communication: Airborne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves (1990) Proc Natl Acad Sci USA, 87, pp. 7713-7716
dc.descriptionReymond, P., Bodenhausen, N., Van Poecke, R.M.P., Krishnamurthy, V., Dicke, M., Farmer, E.E., A conserved transcript pattern in response to a specialist and a generalist herbivore (2004) The Plant Cell, 16, pp. 3132-3147
dc.descriptionZhao, J., Davis, L.C., Verpoorte, R., Elicitor signal transduction leading to production of plant secondary metabolites (2005) Biotechnol Adv, 23, pp. 283-333
dc.descriptionGundlach, H., Müller, M.J., Kutchan, T.M., Zenk, M.H., Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures (1992) Proc Natl Acad Sci USA, 89, pp. 2389-2393
dc.descriptionHu, F.X., Zhong, J.J., Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate (2008) Process Biochem, 43, pp. 113-118
dc.descriptionPhisalaphong, M., Linden, J.C., Ethylene and methyl jasmonate interaction and induction models for elicited biosynthetic steps of paclitaxel in suspension cultures of Taxus canadensis (1999) Biology and Biotechnology of the Plant Hormone Ethylene, pp. 85-94
dc.descriptionPhisalaphong, M., Linden, J.C., Kinetic studies of paclitaxel production by Taxus canadensis culture in batch and semi-continuous with total cell recycle (1999) Biotechnol Progr, 15, pp. 1072-1077
dc.descriptionLinden, J.C., Phisalaphong, M., Oligosaccharides potentiate methyl jasmonate induced production of paclitaxel in Taxus canadensis (2000) Plant Sci, 158, pp. 41-51
dc.descriptionSenger, R.S., Phisalaphong, M., Karim, M.N., Linden, J.C., Development of a culture sub-population induction model: Signaling pathways synergy and taxanes production by Taxus canadensis (2006) Biotechnol Progr, 22, pp. 1671-1682
dc.descriptionMirjalili, N., Linden, J.C., Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: Ethylene Interaction and induction models (1996) Biotechnol Progr, 12, pp. 110-118
dc.descriptionLuo, J., He, G.Y., Optimization of elicitors and precursors for paclitaxel production in cell suspension culture of Taxus chinensis in the presence of nutrient feeding (2004) Process Biochem, 39, pp. 1073-1079
dc.descriptionLuckner, M., Structure, biosynthesis, and metabolism of secondary products in microorganisms, plants, and animals (1990) Secondary Metabolism in Microorganisms, Plants, and Animals, , Springer-Verlag New York
dc.descriptionFreeman, A., Woodley, J.M., Lilly, M.D., In situ product removal as a tool for bioprocessing (1993) Nat Biotechnol, 11, pp. 1007-1012
dc.descriptionChiang, L., Abdullah, M.A., Enhanced anthraquinones production from adsorbent-treated Morinda elliptica cell suspension cultures in production medium strategy (2007) Process Biochem, 42, pp. 757-763
dc.descriptionHooker, B.S., Lee, J.M., Cultivation of plant cells in aqueous two-phase polymer systems (1990) Plant Cell Rep, 8, pp. 546-549
dc.descriptionWu, Z.L., Yuan, Y.J., Liu, J.X., Xuan, H.Y., Hu, Z.D., Sun, A.C., Study on enhanced production of taxol from Taxus chinensis var. mairei in biphasic-liquid culture (1999) Acta Bot Sin, 41, pp. 1108-1113
dc.descriptionYuan, Y.J., Wei, Z.J., Wu, Z.L., Wu, J.C., Improved Taxol production in suspension cultures of Taxus chinensis var. mairei by in situ extraction combined with precursor feeding and additional carbon source introduction in an airlift loop reactor (2001) Biotechnol Lett, 23, pp. 1659-1662
dc.descriptionCollins-Pavao, M., Chin, C.K., Pedersen, H., Taxol partitioning in two-phase plant cell cultures of Taxus brevifolia (1996) J Biotechnol, 49, pp. 95-100
dc.descriptionKwon, I.C., Yoo, Y.J., Lee, J.H., Hyun, J.O., Enhancement of taxol production by in situ recovery of product (1998) Process Biochem, 33, pp. 701-708
dc.descriptionBrodelius, P., Mosbach, K., Immobilized plant cells (1982) Appl Biochem Biotech, 7, pp. 31-34
dc.descriptionLindsey, K., Yeoman, M.M., Immobilized plant cells (1987) Plant Cell Culture Technology, pp. 228-270
dc.descriptionDörnenburg, H., Evaluation of immobilisation effects on metabolic activities and productivity in plant cell processes (2004) Process Biochem, 39, pp. 1369-1375
dc.descriptionVillegas, M., León, R., Brodelius, P.E., Effects of alginate and immobilization by entrapment in alginate on benzophenanthridine alkaloid production in cell suspension cultures of Eschscholtzia californica (1999) Biotechnol Lett, 21, pp. 49-55
dc.descriptionSrinivasan, V., Pestchanker, L., Moser, S., Hirasuna, T.J., Taticek, R.A., Shuler, M.L., Taxol production in bioreactors: Kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata (1995) Biotechnol Bioeng, 47, pp. 666-676
dc.descriptionRoberts, S.C., Shuler, M.L., Large-scale plant cell culture (1997) Curr Opin Biotech, 8, pp. 154-159
dc.descriptionKolewe, M.E., Gaurav, V., Roberts, S.C., Pharmaceutically active natural product synthesis and supply via plant cell culture technology (2008) Mol Pharmaceut, 5, pp. 243-256
dc.descriptionKatkovcinová, Z., Lázárová, M., Brunáková, K., Košuth, J., Cellárová, E., Expression of dbat and dbtnbt genes involved in paclitaxel biosynthesis during the growth cycle of Taxus baccata L. callus cultures (2008) Verlag der Zeitschrift fur Naturforschung, 63, pp. 721-730
dc.descriptionBrunáková, K., Košuth, J., Gene expression profiling in Taxus baccata L. seedlings and cell cultures (2009) Protocols for in Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, 547
dc.descriptionFornal, S., Esposti, D.D., Navia-Osorio, A., Cusid, R.M., Palazn, J., Teresa Piñol, M., Taxol transport in Taxus baccata cell suspension cultures (2002) Plant Physiol Biochem, 40, pp. 81-88
dc.descriptionMoyano, E., Gene, A., Bonfill, M., Cusido, R.M., Palazon, J., Pinol, M.T., Improvement of paclitaxel and baccatin III production in Taxus sp. cell cultures (2004) Recent Res Dev Biochem, 5, pp. 239-253
dc.descriptionBonfill, M., Bentebibel, S., Moyano, E., Palazon, J., Cusidó, R.M., Eibl, R., Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata (2007) Biol Plantarum, 51, pp. 647-652
dc.descriptionGuo, B.H., Kai, G.Y., Jin, H.B., Tang, K.X., Taxol synthesis (2006) Afr J Biotechnol, 5, pp. 15-20
dc.languageen
dc.publisher
dc.relationProcess Biochemistry
dc.rightsfechado
dc.sourceScopus
dc.titleProduction Of The Anticancer Drug Taxol In Taxus Baccata Suspension Cultures: A Review
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución