Volutin Granules Of Eimeria Parasites Are Acidic Compartments And Have Physiological And Structural Characteristics Similar To Acidocalcisomes

dc.creatorSoares Medeiros L.C.
dc.creatorGomes F.
dc.creatorMacIel L.R.M.
dc.creatorSeabra S.H.
dc.creatorDocampo R.
dc.creatorMoreno S.
dc.creatorPlattner H.
dc.creatorHentschel J.
dc.creatorKawazoe U.
dc.creatorBarrabin H.
dc.creatorDe Souza W.
dc.creatorDamatta R.A.
dc.creatorMiranda K.
dc.date2011
dc.date2015-06-30T20:43:03Z
dc.date2015-11-26T14:53:58Z
dc.date2015-06-30T20:43:03Z
dc.date2015-11-26T14:53:58Z
dc.date.accessioned2018-03-28T22:05:49Z
dc.date.available2018-03-28T22:05:49Z
dc.identifier
dc.identifierJournal Of Eukaryotic Microbiology. , v. 58, n. 5, p. 416 - 423, 2011.
dc.identifier10665234
dc.identifier10.1111/j.1550-7408.2011.00565.x
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80053186828&partnerID=40&md5=20cbdaa92ca860f3357006bc0845c8f2
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108964
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108964
dc.identifier2-s2.0-80053186828
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255044
dc.descriptionThe structural organization of parasites has been the subject of investigation by many groups and has lead to the identification of structures and metabolic pathways that may represent targets for anti-parasitic drugs. A specific group of organelles named acidocalcisomes has been identified in a number of organisms, including the apicomplexan parasites such as Toxoplasma and Plasmodium, where they have been shown to be involved in cation homeostasis, polyphosphate metabolism, and osmoregulation. Their structural counterparts in the apicomplexan parasite Eimeria have not been fully characterized. In this work, the ultrastructural and chemical properties of acidocalcisomes in Eimeria were characterized. Electron microscopy analysis of Eimeria parasites showed the dense organelles called volutin granules similar to acidocalcisomes. Immunolocalization of the vacuolar proton pyrophosphatase, considered as a marker for acidocalcisomes, showed labeling in vesicles of size and distribution similar to the dense organelles seen by electron microscopy. Spectrophotometric measurements of the kinetics of proton uptake showed a vacuolar proton pyrophosphatase activity. X-ray mapping revealed significant amounts of Na, Mg, P, K, Ca, and Zn in their matrix. The results suggest that volutin granules of Eimeria parasites are acidic, dense organelles, and possess structural and chemical properties analogous to those of other acidocalcisomes, suggesting a similar functional role in these parasites. © 2011 International Society of Protistologists.
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dc.languageen
dc.publisher
dc.relationJournal of Eukaryotic Microbiology
dc.rightsfechado
dc.sourceScopus
dc.titleVolutin Granules Of Eimeria Parasites Are Acidic Compartments And Have Physiological And Structural Characteristics Similar To Acidocalcisomes
dc.typeArtículos de revistas


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