Artículos de revistas
Subfertility Phenotype, Chromosome Polymorphismand Conception Failures [fenótipo De Subfertilidade, Polimorfismos Cromossômicos E Falhas De Concepção]
Revista Brasileira De Ginecologia E Obstetricia. , v. 33, n. 5, p. 246 - 251, 2011.
de Lourdes Campanhol C.
Purpose: to evaluate the prevalence of cytogenetic alterations and chromosomic polymorphism in couples with a subfertility phenotype in a Brazilian population. Methods: karyotype analysis through G and C banding of 1,236 individuals who presented the subfertility phenotype, from two different centers (public and private) were included in the study. These patients were classified in two sub-groups: one with two or more gestational consecutive losses or not and the o with, at least, one gestacional loss or absence of conception. Karyotype results were evaluated in different groups and frequencies were calculated. Statistical analyses were carried out through Fisher's exact test and Odds Ratio analysis. Results: approximately 25% of the cases presented abnormal karyotype results, including numerical and structural alterations and also polymorphic variants. In both centers, the prevalence of polymorphic variants was 8.9 and 3.8%, respectively. 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