Artículos de revistas
Clinical And Pathological Implications Of Concurrent Autoimmune Thyroid Disorders And Papillary Thyroid Cancer
Registro en:
Journal Of Thyroid Research. , v. 2011, n. , p. - , 2011.
10.4061/2011/387062
2-s2.0-80052400954
Autor
Cunha L.L.
Ferreira R.C.
Marcello M.A.
Vassallo J.
Ward L.S.
Institución
Resumen
Cooccurrences of chronic lymphocytic thyroiditis (CLT) and thyroid cancer (DTC) have been repeatedly reported. Both CLT and DTC, mainly papillary thyroid carcinoma (PTC), share some epidemiological and molecular features. In fact, thyroid lymphocytic inflammatory reaction has been observed in association with PTC at variable frequency, although the precise relationship between the two diseases is still debated. It also remains a matter of debate whether the association with a CLT or even an autoimmune disorder could influence the prognosis of PTC. A better understanding about clinical implications of autoimmunity in concurrent thyroid cancer could raise new insights of thyroid cancer immunotherapy. In addition, elucidating the molecular mechanisms involved in autoimmune disease and concurrent cancer allowed us to identify new therapeutic strategies against thyroid cancer. The objective of this article was to review recent literature on the association of these disorders and its potential significance. © 2011 L. L. Cunha et al. 2011 Cancer Facts & Figures, , American Cancer Society, The Society, Atlanta, Ga, USA Davies, L., Welch, H.G., Increasing incidence of thyroid cancer in the United States, 1973-2002 (2006) Journal of the American Medical Association, 295 (18), pp. 2164-2167 Burgess, J.R., Tucker, P., Incidence trends for papillary thyroid carcinoma and their correlation with thyroid surgery and thyroid fine-needle aspirate cytology (2006) Thyroid, 16 (1), pp. 47-53. , DOI 10.1089/thy.2006.16.47 Kilfoy, B.A., Zheng, T., Holford, T.R., International patterns and trends in thyroid cancer incidence, 1973-2002 (2009) Cancer Causes and Control, 20 (5), pp. 525-531 Nikiforov, Y.E., Is ionizing radiation responsible for the increasing incidence of thyroid cancer? (2010) Cancer, 116 (7), pp. 1626-1628 Wartofsky, L., Increasing world incidence of thyroid cancer: Increased detection or higher radiation exposure? (2010) Hormones, 9 (2), pp. 103-108 Pellegriti, G., De Vathaire, F., Scollo, C., Papillary thyroid cancer incidence in the volcanic area of sicily (2009) Journal of the National Cancer Institute, 101 (22), pp. 1575-1583 Williams, E.D., Abrosimov, A., Bogdanova, T., Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake (2008) Thyroid, 18 (8), pp. 847-852 Liu, X.H., Chen, G.G., Vlantis, A.C., Van Hasselt, C.A., Iodine mediated mechanisms and thyroid carcinoma (2009) Critical Reviews in Clinical Laboratory Sciences, 46 (5-6), pp. 302-318 Chen, A.Y., Jemal, A., Ward, E.M., Increasing incidence of differentiated thyroid cancer in the United States, 1988 2005 (2009) Cancer, 115 (16), pp. 3801-3807 Renehan, A.G., Soerjomataram, I., Tyson, M., Incident cancer burden attributable to excess body mass index in 30 European countries (2010) International Journal of Cancer, 126 (3), pp. 692-702 Todaro, M., Lombardo, Y., Francipane, M.G., Perez Alea, M., Cammareri, P., Iovino, F., Di Stefano, A.B., Stassi, G., Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4 (2008) Cell Death and Differentiation, 15 (4), pp. 762-772. , DOI 10.1038/sj.cdd.4402305, PII 4402305, The biology of Hypoxia-inducible factors Russell, J.P., Shinohara, S., Melillo, R.M., Castellone, M.D., Santoro, M., Rothstein, J.L., Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors (2003) Oncogene, 22 (29), pp. 4569-4577. , DOI 10.1038/sj.onc.1206759 Russell, J.P., Engiles, J.B., Rothstein, J.L., Proinflammatory mediators and genetic background in oncogene mediated tumor progression (2004) Journal of Immunology, 172 (7), pp. 4059-4067 Puxeddu, E., Mitsutake, N., Knauf, J.A., Moretti, S., Kim, H.W., Seta, K.A., Brockman, D., Fagin, J.A., Microsomal Prostaglandin E2 Synthase-1 Is Induced by Conditional Expression of RET/PTC in Thyroid PCCL3 Cells through the Activation of the MEK-ERK Pathway (2003) Journal of Biological Chemistry, 278 (52), pp. 52131-52138. , DOI 10.1074/jbc.M306003200 Shinohara, S., Rothstein, J.L., Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells (2004) Oncogene, 23 (45), pp. 7571-7579. , DOI 10.1038/sj.onc.1207964 Puxeddu, E., Knauf, J.A., Sartor, M.A., Mitsutake, N., Smith, E.P., Medvedovic, M., Tomlinson, C.R., Fagin, J.A., RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response (2005) Endocrine-Related Cancer, 12 (2), pp. 319-334. , DOI 10.1677/erc.1.00947 Sumimoto, H., Imabayashi, F., Iwata, T., Kawakami, Y., The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells (2006) Journal of Experimental Medicine, 203 (7), pp. 1651-1656. , http://www.jem.org/cgi/reprint/203/7/1651, DOI 10.1084/jem.20051848 Crawford, S., Belajic, D., Wei, J., Riley, J.P., Dunford, P.J., Bembenek, S., Fourie, A., Blevitt, J.M., A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker (2008) Molecular Cancer Therapeutics, 7 (3), pp. 492-499. , http://mct.aacrjournals.org/cgi/reprint/7/3/492, DOI 10.1158/1535-7163.MCT-07-0307 Harach, H.R., Solid cell nests of the thyroid (1988) Journal of Pathology, 155 (3), pp. 191-200 Cameselle-Teijeiro, J., Varela-Duran, J., Sambade, C., Villanueva, J.P., Varela- Nunez, R., Sobrinho-Simoes, M., Solid cell nests of the thyroid: Light microscopy and immunohistochemical profile (1994) Human Pathology, 25 (7), pp. 684-693. , DOI 10.1016/0046-8177(94)90302-6 Morari, E.C., Pereira Leite, J.L., Granja, F., Montalli Da Assumpcao, L.V., Ward, L.S., The null genotype of glutathione S-transferase M1 and T1 locus increases the risk for thyroid cancer (2002) Cancer Epidemiology Biomarkers and Prevention, 11 (11), pp. 1485-1488 Martin, V., Martin, L., Viennet, G., Hergel, M., Carbillet, J.-P., Fellmann, D., Ultrastructural features of 'solid cell nest' of the human thyroid gland: A study of 8 cases (2000) Ultrastructural Pathology, 24 (1), pp. 1-8 Harach, H.R., Mixed follicles of the human thyroid gland (1987) Acta Anatomica, 129 (1), pp. 27-30 Bykov, V.L., Tissue of ultimobranchial origin in normal and pathologically altered thyroid gland (1993) Arkhiv Patologii, 55 (5), pp. 81-84 Fraser, B.A., Duckworth, J.W.A., Ultimobranchial body cysts in the human foetal thyroid: Pathological implications (1979) Journal of Pathology, 127 (2), pp. 89-92. , DOI 10.1002/path.1711270206 Mizukami, Y., Nonomura, A., Michigishi, T., Noguchi, M., Hashimoto, T., Nakamura, S., Ishizaki, T., Solid cell nests of the thyroid: A histologic and immunohistochemical study (1994) American Journal of Clinical Pathology, 101 (2), pp. 186-191 Ozaki, O., Ito, K., Sugino, K., Solid cell nests of the thyroid gland (1991) Virchows Archiv-A Pathological Anatomy and Histopathology, 418 (3), pp. 201-205 Beckner, M.E., Shultz, J.J., Richardson, T., Solid and cystic ultimobranchial body remnants in the thyroid (1990) Archives of Pathology and Laboratory Medicine, 114 (10), pp. 1049-1052 Martin, V., Martin, L., Viennet, G., Challier, B., Carbillet, J.-P., Fellmann, D., Solid Cell Nests and thyroid pathologies. Retrospective study of 1 390 thyroids (2000) Annales de Pathologie, 20 (3), pp. 196-201 Chan, J.K.C., Tse, C.C.H., Solid cell nest-associated C-cells: Another possible explanation for "C-cell hyperplasia" adjacent to follicular cell tumors (1989) Human Pathology, 20 (5), pp. 498-499 Cameselle-Teijeiro, J., Febles-Perez, C., Sobrinho-Simoes, M., Papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation. A case report with histologic and immunohistochemical findings that support a provocative histogenetic hypothesis (1995) Pathology Research and Practice, 191 (12), pp. 1214-1221 Granja, F., Morari, J., Morari, E.C., Correa, L.A.C., Assumpcao, L.V.M., Ward, L.S., GST profiling may be useful in the screening for thyroid nodule malignancy (2004) Cancer Letters, 209 (2), pp. 129-137. , DOI 10.1016/j.canlet.2003.12.013, PII S0304383503008589 Williams, E.D., Toyn, C.E., Harach, H.R., The ultimobranchial gland and congenital thyroid abnormalities in man (1989) Journal of Pathology, 159 (2), pp. 135-141 Unger, P., Ewart, M., Wang, B.Y., Gan, L., Kohtz, D.S., Burstein, D.E., Expression of p63 in papillary thyroid carcinoma and in Hashimoto's thyroiditis: A pathobiologic link? (2003) Human Pathology, 34 (8), pp. 764-769. , DOI 10.1016/S0046-8177(03)00239-9 Burstein, D.E., Nagi, C., Wang, B.Y., Unger, P., Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis (2004) Human Pathology, 35 (4), pp. 465-473. , DOI 10.1016/j.humpath.2003.10.027 Preto, A., Cameselle-Teijeiro, J., Moldes-Boullosa, J., Soares, P., Cameselle-Teijeiro, J.F., Silva, P., Reis-Filho, J.S., Sobrinho-Simoes, M., Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests (2004) Modern Pathology, 17 (7), pp. 819-826. , DOI 10.1038/modpathol.3800124 Asioli, S., Erickson, L.A., Lloyd, R.V., Solid cell nests in hashimoto's thyroiditis sharing features with papillary thyroid microcarcinoma (2009) Endocrine Pathology, 20 (4), pp. 197-203 Reis-Filho, J.S., Preto, A., Soares, P., Ricardo, S., Cameselle-Teijeiro, J., Sobrinho-Simoes, M., P63 expression in solid cell nests of the thyroid: Further evidence for a stem cell origin (2003) Modern Pathology, 16 (1), pp. 43-48. , DOI 10.1097/01.MP.0000047306.72278.39 Vollenweider, I., Hedinger, C., Solid cell nests (SCN) in Hashimoto's thyroiditis (1988) Virchows Archiv - A Pathological Anatomy and Histopathology, 412 (4), pp. 357-363 Prod'Hom, G., Hedinger, C., Relation between 'solid cell nests' and focal lymphocytic thyroiditis (1985) Annales de Pathologie, 5 (4-5), pp. 265-270 Cameselle-Teijeiro, J., Abdulkader, I., Perez-Becerra, R., BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? (2009) Human Pathology, 40 (7), pp. 1029-1035 Harii, N., Lewis, C.J., Vasko, V., McCall, K., Benavides-Peralta, U., Sun, X., Ringel, M.D., Kohn, L.D., Thyrocytes express a functional Toll-like receptor 3: Overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis (2005) Molecular Endocrinology, 19 (5), pp. 1231-1250. , DOI 10.1210/me.2004-0100 Granja, F., Morari, J., Morari, E.C., Correa, L.A.C., Assumpcao, L.V.M., Ward, L.S., Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer (2004) Cancer Letters, 210 (2), pp. 151-157. , DOI 10.1016/j.canlet.2004.01.016, PII S030438350400076X Takeda, K., Akira, S., Microbial recognition by Toll-like receptors (2004) Journal of Dermatological Science, 34 (2), pp. 73-82. , DOI 10.1016/j.jdermsci.2003.10.002, PII S0923181103002226 Underhill, D.M., Toll-like receptors: Networking for success (2003) European Journal of Immunology, 33 (7), pp. 1767-1775. , DOI 10.1002/eji.200324037 Barton, G.M., Medzhitov, R., Toll-like receptor signaling pathways (2003) Science, 300 (5625), pp. 1524-1525. , DOI 10.1126/science.1085536 Takeda, K., Kaisho, T., Akira, S., Toll-like receptors (2003) Annual Review of Immunology, 21, pp. 335-376. , DOI 10.1146/annurev.immunol.21.120601.141126 Muzio, M., Bosisio, D., Polentarutti, N., D'amico, G., Stoppacciaro, A., Mancinelli, R., Van't Veer, C., Mantovani, A., Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells (2000) Journal of Immunology, 164 (11), pp. 5998-6004 McCall, K.D., Harii, N., Lewis, C.J., Malgor, R., Won, B.K., Saji, M., Kohn, A.D., Kohn, L.D., High basal levels of functional Toll-Like Receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration (2007) Endocrinology, 148 (9), pp. 4226-4237. , http://endo.endojournals.org/cgi/reprint/148/9/4226, DOI 10.1210/en.2007-0459 Sancar, A., Lindsey-Boltz, L.A., Unsal-Kacmaz, K., Linn, S., Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints (2004) Annual Review of Biochemistry, 73, pp. 39-85. , DOI 10.1146/annurev.biochem.73.011303.073723 Gasser, S., Raulet, D., The DNA damage response, immunity and cancer (2006) Seminars in Cancer Biology, 16 (5), pp. 344-347. , DOI 10.1016/j.semcancer.2006.07.004, PII S1044579X06000551, Natural Killer Cells in Cancer Gomez, G.G., Hickey, M.J., Tritz, R., Kruse, C.A., Immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes: Downregulation of multiple proapoptotic factors (2008) Gene Therapy and Molecular Biology, 12 (1), pp. 101-110 Gasser, S., Orsulic, S., Brown, E.J., Raulet, D.H., The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor (2005) Nature, 436 (7054), pp. 1186-1190. , DOI 10.1038/nature03884 Granja, F., Morari, E.C., Assumpcao, L.V.M., Ward, L.S., GSTO polymorphism analysis in thyroid nodules suggest that GSTO1 variants do not influence the risk for malignancy (2005) European Journal of Cancer Prevention, 14 (3), pp. 277-280. , DOI 10.1097/00008469-200506000-00013 Akulevich, N.M., Saenko, V.A., Rogounovitch, T.I., Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma (2009) Endocrine-Related Cancer, 16 (2), pp. 491-503 Dombernowsky, S.L., Weischer, M., Allin, K.H., Bojesen, S.E., Tybjærg-Hansen, A., Nordestgaard, B.G., Risk of cancer by ATM missense mutations in the general population (2008) Journal of Clinical Oncology, 26 (18), pp. 3057-3062 Royer, M.C., Zhang, H., Fan, C.Y., Kokoska, M.S., Genetic alterations in papillary thyroid carcinoma and hashimoto thyroiditis: An analysis of hOGG1 loss of heterozygosity (2010) Archives of Otolaryngology, 136 (3), pp. 240-242 Ozaki, O., Ito, K., Kobayashi, K., Toshima, K., Iwasaki, H., Yashiro, T., Thyroid carcinoma in Graves' disease (1990) World Journal of Surgery, 14 (3), pp. 437-440 Gupta, S., Patel, A., Folstad, A., Fenton, C., Dinauer, C.A., Tuttle, R.M., Conran, R., Francis, G.L., Infiltration of differentiated thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival for children and young adults (2001) Journal of Clinical Endocrinology and Metabolism, 86 (3), pp. 1346-1354. , DOI 10.1210/jc.86.3.1346 Maceri, D.R., Sullivan, M.J., McClatchney, K.D., Autoimmune thyroiditis: Pathophysiology and relationship to thyroid cancer (1986) Laryngoscope, 96 (1), pp. 83-86 Crile, G., Struma lymphomatosa and carcinoma of the thyroid (1978) Surgery Gynecology and Obstetrics, 147 (3), pp. 350-352 Holm, L.E., Blomgren, H., Lowhagen, T., Cancer risks in patients with chronic lymphocytic thyroiditis (1985) New England Journal of Medicine, 312 (10), pp. 601-604 Ramos, A.M.D.O., Sales, A.D.O., Barbalho De Mello, L.E., Absence of peritumoral fibrosis or inflammatory infiltrate may be related to clinical progression of papillary thyroid microcarcinoma (2009) International Journal of Surgical Pathology, 17 (6), pp. 432-437 Lucas, S.D., Karlsson-Parra, A., Nilsson, B., Grimelius, L., Akerstrom, G., Rastad, J., Juhlin, C., Tumor-specific deposition of immunoglobulin g and complement in papillary thyroid carcinoma (1996) Human Pathology, 27 (12), pp. 1329-1335. , DOI 10.1016/S0046-8177(96)90346-9 Bufalo, N.E., Leite, J.L., Guilhen, A.C.T., Morari, E.C., Granja, F., Assumpcao, L.V.M., Ward, L.S., Smoking and susceptibility to thyroid cancer: An inverse association with CYP1A1 allelic variants (2006) Endocrine-Related Cancer, 13 (4), pp. 1185-1193. , DOI 10.1677/ERC-06-0002 Sakorafas, G.H., Giotakis, J., Stafyla, V., Papillary thyroid microc Guilhen, A.C.T., Bufalo, N.E., Morari, E.C., Role of the N-Acetyltransferase 2 Detoxification system in thyroid cancer susceptibility (2009) Clinical Cancer Research, 15 (1), pp. 406-412 Ostroumova, E., Brenner, A., Oliynyk, V., Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident (1998&2000) (2009) Environmental Health Perspectives, 117 (5), pp. 745-750 Gomez Segovia, I., Gallowitsch, H.J., Kresnik, E., Kumnig, G., Igerc, I., Matschnig, S., Stronegger, W.J., Lind, P., Descriptive epidemiology of thyroid carcinoma in carinthia, austria: 1984-2001. histopathologic features and tumor classification of 734 cases under elevated general iodination of table salt since 1990: Population-based age-stratified analysis on thyroid carcinoma incidence (2004) Thyroid, 14 (4), pp. 277-286. , DOI 10.1089/105072504323030933 Laurberg, P., Cerqueira, C., Ovesen, L., Iodine intake as a determinant of thyroid disorders in populations (2010) Best Practice and Research, 24 (1), pp. 13-27 Dailey, M.E., Lindsay, S., Skahen, R., Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland (1955) Archives of Surgery, 70 (2), pp. 291-297 Crile Jr., G., Fisher, E.R., Simultaneous occurrence of thyroiditis and papillary carcinoma report of two cases (1953) Cancer, 6 (1), pp. 57-62 Hirabayashi, R.N., Lindsay, S., The relation of thyroid carcinoma and chronic thyroiditis (1965) Surgery, Gynecology & Obstetrics, 121, pp. 243-252 Schlicke, C.P., Hill, J.E., Schultz, G.F., Carcinoma in chronic thyroiditis (1960) Surgery, Gynecology & Obstetrics, 111, pp. 552-556 Clark, O.H., Greenspan, F.S., Dunphy, J.E., Hashimoto's thyroiditis and thyroid cancer: Indications for operation (1980) American Journal of Surgery, 140 (1), pp. 65-71 Lindsay, S., Dailey, M.E., Friedlander, J., Yee, G., Soley, M.H., Chronic thyroiditis: A clinical and pathologic study of 354 patients (1952) The Journal of Clinical Endocrinology and Metabolism, 12 (12), pp. 1578-1600 Meier, D.W., Woolner, O.H., Beahrs, P.H.G., Mc, C.W., Parenchymal findings in thyroidal carcinoma: Pathologic study of 256 cases (1959) Journal of Clinical Endocrinology & Metabolism, 19 (1), pp. 162-171 Kebebew, E., Treseler, P.A., Ituarte, P.H.G., Clark, O.H., Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited (2001) World Journal of Surgery, 25 (5), pp. 632-637. , DOI 10.1007/s002680020165 Bloodworth, J.M.B., Lechago, J., Gould, V.E., (1996) Bloodworth's Endocrine Pathology, , Williams & Wilkins, Baltimore, Md, USA, 3rd edition Singh, B., Shaha, A.R., Trivedi, H., Carew, J.F., Poluri, A., Shah, J.P., Coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma: Impact on presentation, management, and outcome (1999) Surgery, 126 (6), pp. 1070-1077 Ward, L.S., Assumpcao, L.V.M., The impact of gender in differentiated thyroid cancer (2007) Clinical Endocrinology, 66 (5), pp. 752-753 De Matos, P.S., Ferreira, A.P.C., Ward, L.S., Prevalence of papillary microcarcinoma of the thyroid in Brazilian autopsy and surgical series (2006) Endocrine Pathology, 17 (2), pp. 165-173. , DOI 10.1385/EP:17:2:165, PII EP172165 Matsubayashi, S., Kawai, K., Matsumoto, Y., The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland (1995) Journal of Clinical Endocrinology and Metabolism, 80 (12), pp. 3419-3424 Kashima, K., Yokoyama, S., Noguchi, S., Murakami, N., Yamashita, H., Watanabe, S., Uchino, S., Nakayama, I., Chronic thyroiditis as a favorable prognostic factor in papillary thyroid carcinoma (1998) Thyroid, 8 (3), pp. 197-202 Asanuma, K., Sugenoya, A., Kasuga, Y., Itoh, N., Kobayashi, S., Amano, J., The relationship between multiple intrathyroidal involvement in papillary thyroid carcinoma and chronic non-specific thyroiditis (1998) Cancer Letters, 122 (1-2), pp. 177-180. , DOI 10.1016/S0304-3835(97)00398-4, PII S0304383597003984 Schaffler, A., Palitzsch, K.-D., Seiffarth, C., Hohne, H.M., Riedhammer, F.J., Hofstadter, F., Scholmerich, J., Ruschoff, J., Coexistent thyroiditis is associated with lower tumour stage in thyroid carcinoma (1998) European Journal of Clinical Investigation, 28 (10), pp. 838-844. , DOI 10.1046/j.1365-2362.1998.00363.x Loh, K.-C., Greenspan, F.S., Dong, F., Miller, T.R., Yeo, P.P.B., Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma (1999) Journal of Clinical Endocrinology and Metabolism, 84 (2), pp. 458-463. , DOI 10.1210/jc.84.2.458 Lisboa Souza, S., Vera Montalli Da Assumpcao, L., Sterian Ward, L., Impact of previous thyroid autoimmune diseases on prognosis of patients with well-differentiated thyroid cancer (2003) Thyroid, 13 (5), pp. 491-495 Kim, S.K., Song, K.H., Lim, S.O.D., Clinical and pathological features and the BRAF mutation in patients with papillary thyroid carcinoma with and without concurrent Hashimoto thyroiditis (2009) Thyroid, 19 (2), pp. 137-141 Kim, E.Y., Kim, W.G., Kim, W.B., Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma (2009) Clinical Endocrinology, 71 (4), pp. 581-586 Muzza, M., Degl'Innocenti, D., Colombo, C., The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: Clinical and molecular studies (2010) Clinical Endocrinology, 72 (5), pp. 702-708 Kim, H.S., Choi, Y.J., Yun, J.I.S., Features of papillary thyroid microcarcinoma in the presence and absence of lymphocytic thyroiditis (2010) Endocrine Pathology, pp. 1-5 Rapoport, B., McLachlan, S.M., Thyroid autoimmunity (2001) Journal of Clinical Investigation, 108 (9), pp. 1253-1259. , DOI 10.1172/JCI200114321 Zenewicz, L.A., Abraham, C., Flavell, R.A., Cho, J.H., Unraveling the genetics of autoimmunity (2010) Cell, 140 (6), pp. 791-797 Michels, A.W., Eisenbarth, G.S., Immunologic endocrine disorders (2010) Journal of Allergy and Clinical Immunology, 125 (2), pp. S226-S237 Burek, C.L., Rose, N.R., Autoimmune thyroiditis and ROS (2008) Autoimmunity Reviews, 7 (7), pp. 530-537 Tomer, Y., Menconi, F., Interferon induced thyroiditis (2009) Best Practice and Research, 23 (6), pp. 703-712 Flynn, J.C., McCormick, D.J., Brusic, V., Wan, Q., Panos, J.C., Giraldo, A.A., David, C.S., Kong, Y.-C.M., Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis (2004) Cellular Immunology, 229 (2), pp. 79-85. , DOI 10.1016/j.cellimm.2004.07.002, PII S0008874904001157 Pacifico, F., Leonardi, A., Role of NF-kB in thyroid cancer (2010) Molecular and Cellular Endocrinology, 321 (1), pp. 29-35 Anil, C., Goksel, S., Gursoy, A., Thyroglobulin antibody is associated with increased cancer risk in thyroid nodules (2010) Thyroid, 20 (8), pp. 885-891 (2004) Drug Discovery Today, , Elsevier Science, Oxford, UK, 10th edition Shu, S., Plautz, G.E., Krauss, J.C., Chang, A.E., Tumor immunology (1997) Journal of the American Medical Association, 278 (22), pp. 1972-1981 Lipford III, E.H., Eggleston, J.C., Lillemoe, K.D., Prognostic factors in surgically resected limited-stage, nonsmall cell carcinoma of the lung (1984) American Journal of Surgical Pathology, 8 (5), pp. 357-365 Kawata, A., Une, Y., Hosokawa, M., Uchino, J., Kobayashi, H., Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma (1992) Japanese Journal of Clinical Oncology, 22 (4), pp. 256-263 Kolbeck, P.C., Kaveggia, F.F., Johansson, S.L., Grune, M.T., Taylor, R.J., The relationships among tumorinfiltrating lymphocytes, histopathologic findings, and longterm clinical follow-up in renal cell carcinoma (1992) Modern Pathology, 5 (4), pp. 420-425 Boyd, C.M., Baker Jr., J.R., The immunology of thyroid cancer (1996) Endocrinology and Metabolism Clinics of North America, 25 (1), pp. 159-179. , DOI 10.1016/S0889-8529(05)70317-0 Tamimi, D.M., The association between chronic lymphocytic thyroiditis and thyroid tumors (2002) International Journal of Surgical Pathology, 10 (2), pp. 141-146 Gul, K., Dirikoc, A., Kiyak, G., The association between thyroid carcinoma and Hashimoto's thyroiditis: The ultrasonographic and histopathologic characteristics of malignant nodules (2010) Thyroid, 20 (8), pp. 873-878 Shull, J.H., Sharon, N., Victor, T.A., Scanlon, E.F., Thyroid carcinoma. Immunology, irradiation, and lymphocytic infiltration (1979) Archives of Surgery, 114 (6), pp. 729-731 Kamma, H., Fujii, K., Ogata, T., Lymphocytic infiltration in juvenile thyroid carcinoma (1988) Cancer, 62 (9), pp. 1988-1993. , DOI 10.1002/1097-0142(19881101)62:9 <1988::AID-CNCR2820620919>3.0. CO;2-0 Sundick, R.S., Iodine in autoimmune thyroiditis (1990) Immunology Series, 52, pp. 213-228 Boi, F., Lai, M.L., Marziani, B., Minerba, L., Faa, G., Mariotti, S., High prevalence of suspicious cytology in thyroid nodules associated with positive thyroid autoantibodies (2005) European Journal of Endocrinology, 153 (5), pp. 637-642. , DOI 10.1530/eje.1.02020 Fiore, E., Rago, T., Scutari, M., Papillary thyroid cancer, although strongly associated with lymphocitic infiltration on histology, is only weakly predicted by serum thyroid autoantibodies in patients with nodular thyroid diseases (2009) Journal of Endocrinological Investigation, 32 (4), pp. 344-351 Boelaert, K., Horacek, J., Holder, R.L., Watkinson, J.C., Sheppard, M.C., Franklyn, J.A., Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration (2006) Journal of Clinical Endocrinology and Metabolism, 91 (11), pp. 4295-4301. , http://jcem.endojournals.org/cgi/reprint/91/11/4295, DOI 10.1210/jc.2006-0527 Rago, T., Di Coscio, G., Ugolini, C., Scutari, M., Basolo, F., Latrofa, F., Romani, R., Vitti, P., Clinical features of thyroid autoimmunity are associated with thyroiditis on histology and are not predictive of malignancy in 570 patients with indeterminate nodules on cytology who had a thyroidectomy (2007) Clinical Endocrinology, 67 (3), pp. 363-369. , DOI 10.1111/j.1365-2265.2007.02892.x Fiore, E., Rago, T., Provenzale, M.A., Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: Thyroid autonomy may play a protective role (2009) Endocrine-Related Cancer, 16 (4), pp. 1251-1260 Erdogan, M., Erdem, N., Cetinkalp, S., Demographic, clinical, laboratory, ultrasonographic, and cytological features of patients with Hashimoto's thyroiditis: Results of a university hospital of 769 patients in Turkey (2009) Endocrine, 36 (3), pp. 486-490 Carson, H.J., Castelli, M.J., Gattuso, P., Incidence of neoplasia in Hashimoto's thyroiditis: A fine-needle aspiration study (1996) Diagnostic Cytopathology, 14 (1), pp. 38-42. , DOI 10.1002/(SICI)1097-0339(199602)14:1 <38::AID-DC8>3.0.CO;2-R Mazzaferri, E.L., Thyroid cancer and Graves' disease (1990) Journal of Clinical Endocrinology and Metabolism, 70 (4), pp. 826-829 Mazzaferri, E.L., Thyroid cancer and Graves' disease: The controversy ten years later (2000) Endocrine Practice, 6 (2), pp. 221-225 Belfiore, A., Garofalo, M.R., Giuffrida, D., Increased aggressiveness of thyroid cancer in patients with Graves' disease (1990) Journal of Clinical Endocrinology and Metabolism, 70 (4), pp. 830-835 Pellegriti, G., Belfiore, A., Giuffrida, D., Lupo, L., Vigneri, R., Outcome of differentiated thyroid cancer in Graves' patients (1998) Journal of Clinical Endocrinology and Metabolism, 83 (8), pp. 2805-2809. , DOI 10.1210/jc.83.8.2805 Belfiore, A., Russo, D., Vigneri, R., Filetti, S., Graves' disease, thyroid nodules and thyroid cancer (2001) Clinical Endocrinology, 55 (6), pp. 711-718. , DOI 10.1046/j.1365-2265.2001.01415.x Yano, Y., Shibuya, H., Kitagawa, W., Nagahama, M., Sugino, K., Ito, K., Ito, K., Recent outcome of grave's disease patients with papillary thyroid cancer (2007) European Journal of Endocrinology, 157 (3), pp. 325-329. , DOI 10.1530/EJE-07-0136 Hales, I.B., McElduff, A., Crummer, P., Does Graves' disease or thyrotoxicosis affect the prognosis of thyroid cancer (1992) Journal of Clinical Endocrinology and Metabolism, 75 (3), pp. 886-889 DeGroot, L.J., Kaplan, E.L., McCormick, M., Straus, F.H., Natural history, treatment, and course of papillary thyroid carcinoma (1990) Journal of Clinical Endocrinology and Metabolism, 71 (2), pp. 414-424 Clark, O.H., Predictors of thyroid tumor aggressiveness (1996) Western Journal of Medicine, 165 (3), pp. 131-138 Balkwill, F., Mantovani, A., Inflammation and cancer: Back to Virchow? (2001) Lancet, 357 (9255), pp. 539-545. , DOI 10.1016/S0140-6736(00)04046-0 Correa, P., Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society Award lecture on cancer epidemiology and prevention (1992) Cancer Research, 52 (24), pp. 6735-6740 Ekbom, A., Helmick, C., Zack, M., Adami, H.-O., Ulcerative colitis and colorectal cancer: A population-based study (1990) New England Journal of Medicine, 323 (18), pp. 1228-1233 De Vries, A.C., Haringsma, J., Kuipers, E.J., The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection (2007) Helicobacter, 12 (1), pp. 1-15. , DOI 10.1111/j.1523-5378.2007.00475.x De Vries, A.C., Van Grieken, N.C.T., Looman, C.W.N., Casparie, M.K., De Vries, E., Meijer, G.A., Kuipers, E.J., Gastric cancer risk in patients with premalignant gastric lesions: A nationwide cohort study in the netherlands (2008) Gastroenterology, 134 (4), pp. 945-952. , DOI 10.1053/j.gastro.2008.01.071, PII S0016508508001777 Weetman, A.P., Cellular immune responses in autoimmune thyroid disease (2004) Clinical Endocrinology, 61 (4), pp. 405-413. , DOI 10.1111/j.1365-2265.2004.02085.x Ciampi, R., Nikiforov, Y.E., Minireview: RET/PTC rearrangements and braf mutations in thyroid tumorigenesis (2007) Endocrinology, 148 (3), pp. 936-941 Zafon, C., Obiols, G., The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practiceVIa de senalizacion dependiente de la proteincinasa de activacion mitogenica en el carcinoma papilar de tiroides. De las bases moleculares a la practica clinica (2009) Endocrinologia y Nutricion, 56 (4), pp. 176-186 Xing, M., BRAF mutation in thyroid cancer (2005) Endocrine-Related Cancer, 12 (2), pp. 245-262. , DOI 10.1677/erc.1.0978 Williams, R.H., Larsen, P.R., (2003) Williams Textbook of Endocrinology, , Saunders, Philadelphia, Pa, USA, 10th edition Wirtschafter, A., Schmidt, R., Rosen, D., Kundu, N., Santoro, M., Fusco, A., Multhaupt, H., Rothstein, J.L., Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis (1997) Laryngoscope, 107 (1), pp. 95-100. , DOI 10.1097/00005537-199701000-00019 Sheils, O.M., O'Leary, J.J., Uhlmann, V., Luttich, K., Sweeney, E.C., Ret/PTC-1 activation in Hashimoto thyroiditis (2000) International Journal of Surgical Pathology, 8 (3), pp. 185-189 Elisei, R., Romei, C., Vorontsova, T., Cosci, B., Veremeychik, V., Kuchinskaya, E., Basolo, F., Pacini, F., RET/PTC rearrangements in thyroid nodules: Studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults (2001) Journal of Clinical Endocrinology and Metabolism, 86 (7), pp. 3211-3216. , DOI 10.1210/jc.86.7.3211 Rhoden, K.J., Unger, K., Salvatore, G., Yilmaz, Y., Vovk, V., Chiappetta, G., Qumsiyeh, M.B., Tallini, G., RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: Follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma (2006) Journal of Clinical Endocrinology and Metabolism, 91 (6), pp. 2414-2423. , http://jcem.endojournals.org/cgi/reprint/91/6/2414, DOI 10.1210/jc.2006-0240 Kang, D.Y., Kim, K.H., Kim, J.M., High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population (2007) Thyroid, 17 (11), pp. 1031-1038 Guarino, V., Castellone, M.D., Avilla, E., Melillo, R.M., Thyroid cancer and inflammation (2010) Molecular and Cellular Endocrinology, 321 (1), pp. 94-102 Coussens, L.M., Werb, Z., Inflammation and cancer (2002) Nature, 420 (6917), pp. 860-867. , DOI 10.1038/nature01322 Colotta, F., Allavena, P., Sica, A., Garl, C., Mantovani, A., Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability (2009) Carcinogenesis, 30 (7), pp. 1073-1081 Castellone, M.D., Cirafici, A.M., De Vita, G., De Falco, V., Malorni, L., Tallin, G., Fagin, J.A., Santoro, M., Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes (2003) Oncogene, 22 (2), pp. 246-255. , DOI 10.1038/sj.onc.1206112 Wang, J., Knauf, J.A., Basu, S., Puxeddu, E., Kuroda, H., Santoro, M., Fusco, A., Fagin, J.A., Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels (2003) Molecular Endocrinology, 17 (7), pp. 1425-1436. , DOI 10.1210/me.2003-0041 Stassi, G., Todaro, M., Zerilli, M., Ricci-Vitiani, L., Di Liberto, D., Patti, M., Florena, A., De Maria, R., Thyroid Cancer Resistance to Chemotherapeutic Drugs via Autocrine Production of Interleukin-4 and Interleukin-10 (2003) Cancer Research, 63 (20), pp. 6784-6790 Conticello, C., Pedini, F., Zeuner, A., Patti, M., Zerilli, M., Stassi, G., Messina, A., De Maria, R., IL-4 Protects Tumor Cells from Anti-CD95 and Chemotherapeutic Agents via Up-Regulation of Antiapoptotic Proteins (2004) Journal of Immunology, 172 (9), pp. 5467-5477