Artículos de revistas
Genetic Profile Of Adenoid Cystic Carcinomas (acc) With High-grade Transformation Versus Solid Type
Registro en:
Cellular Oncology. , v. 34, n. 4, p. 369 - 379, 2011.
22113428
10.1007/s13402-011-0037-5
2-s2.0-84859001103
Autor
Costa A.F.
Altemani A.
Vekony H.
Bloemena E.
Fresno F.
Suarez C.
Llorente J.L.
Hermsen M.
Institución
Resumen
Background ACC can occasionally undergo dedifferentiation also referred to as high-grade transformation (ACCHGT). However, ACC-HGT can also undergo transformation to adenocarcinomas which are not poorly differentiated. ACC-HGT is generally considered to be an aggressive variant of ACC, even more than solid ACC. This study was aimed to describe the genetic changes of ACC-HGT in relation to clinico-pathological features, and to compare results to solid ACC. Methods Genome wide DNA copy number changes were analyzed by microarray CGH in ACC-HGT, four with transformation into moderately differentiated adenocarcinoma (MDA) and two into poorly differentiated carcinoma (PDC), and five solid ACC. In addition, Ki67 index and p53 immunopositivity was assessed. Results ACC-HGT carried fewer copy number changes compared to solid ACC. Two ACC-HGT cases harboured a breakpoint at 6q23, near the cMYB oncogene. The complexity of the genomic profile concurred with the clinical course of the patient. Among the ACC-HGT, p53 positivity significantly increased from the conventional to the transformed (both MDA and PDC) component. Conclusion ACC-HGT may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form in which the poorly differentiated forms (PDC) presents a genetic complexity similar to the solid ACC. © International Society for Cellular Oncology 2011. 34 4 369 379 El-Naggar, A.K., Huvos, A.G., Adenoid cystic carcinoma (2005) World Organization Classification of Tumors. Pathology & Genetics Head and Neck Tumours, pp. 221-222. , ed. by L. Barnes, J.W. Everson, P. Reichart et al. (IARC Press, Lyon Perzin, K.H., Gullane, P., Clairmont, A.C., Adenoid cystic carcinomas arising in salivary glands. 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