Artículos de revistas
Cerebellar Atrophy Is Frequently Associated With Non-paraneoplastic Sensory Neuronopathy [atrofia Cerebelar Não é Um Achado Frequente Em Pacientes Com Neuronopatia Sensi Tiva Não Paraneoplasica]
Registro en:
Arquivos De Neuro-psiquiatria. , v. 69, n. 4, p. 602 - 606, 2011.
0004282X
10.1590/S0004-282X2011000500006
2-s2.0-82155171569
Autor
Damasceno A.
Franca Jr. M.C.
Cendes F.
Nucci A.
Institución
Resumen
Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN, the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. Objective: To evaluate cerebellar atrophy in SN. Method: We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls. Results: Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN. Conclusion: Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients. 69 4 602 606 Sghirlanzoni, A., Pareyson, D., Lauria, G., Sensory neuron diseases (2005) Lancet Neurol, 4, pp. 349-361 Lauria, G., Pareyson, D., Grisoli, M., Sghirlanzoni, A., Clinical and magnetic resonance imaging findings in chronic sensory ganglionopathies (2000) Ann Neurol, 47, pp. 104-109 França, M.C., D'abreu, A., Zanardi, V.A., MRI shows dorsal lesions and spinal cord atrophy in chronic sensory neuronopathies (2008) J Neuroimaging, 18, pp. 168-172 Damasceno, A., França, M.C., Zanardi, V.A., Nucci, A., Brainstem involvement in Sjögren's syndrome-related sensory neuronopathy (2010) J Neuroimaging, 20, pp. 397-399 Subramony, S.H., May, W., Lynch, D., Cooperative Ataxia Group. Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale (2005) Neurology, 64, pp. 1261-1262 Lynch, D.R., Farmer, J.M., Tsou, A.Y., Measuring Friedreich ataxia: Complementary features of examination and performance measures (2006) Neurology, 66, pp. 1711-1716 Damasceno, A., França Jr., M.C., Nucci, A., Chronic acquired sensory neuron diseases (2008) Eur J Neurol, 15, pp. 1400-1405 Carnevalle, A.D., Rondina, J.M., Kobayashi, E., Cendes, F., Validation of a semiautomated system for MRI-based hippocampal volumetry in patients with temporal lobe epilepsy (2003) J Epilepsy Clin Neurophysiol, 9, pp. 97-104 Denny-Brown, D., Primary sensory neuropathy with muscular changes associated with carcinoma (1948) J Neurol Neurosurg Psychiatry, 11, pp. 73-87 Lauria, G., Pareyson, D., Sghirlanzoni, A., Neurophysiological diagnosis of acquired sensory ganglionopathies (2003) Eur Neurol, 50, pp. 146-152 Altermatt, H.J., Rodriguez, M., Scheithauer, B.W., Lennon, V.A., Paraneoplastic anti-Purkinje and type I anti-neuronal nuclear autoantibodies bind se - lectively to central, peripheral, and autonomic nervous system cells (1991) Lab Invest, 65, pp. 412-420 Nemni, R., Camerlingo, M., Fazio, R., Serum antibodies to Purkinje cells and dorsal root ganglia neurons in sensory neuronopathy without malignancy (1993) Ann Neurol, 34, pp. 848-854 Campbell, W.W., Coordination and gait (2005) Dejong's the Neurologic Examination, pp. 511-534. , In: Campbell WW, Philadelphia: Lippincott Williams & Wilkins França Jr., M.C., D'abreu, A., Yasuda, C.L., A combined voxel-based mor - phometry and 1H-MRS study in patients with Friedreich's ataxia (2009) J Neurol, 256, pp. 1114-1120 Ichikawa, H., Ishihara, K., Fujimoto, R., An autopsied case of Sjogren's syndrome with massive necrotic and demyelinating lesions of the cere - bellar white matter (2004) J Neurol Sci, 225, pp. 143-148