Alpha-hemoglobin-stabilizing Protein: An Erythroid Molecular Chaperone

dc.creatorCosta F.F.
dc.creatorFavero M.E.
dc.date2011
dc.date2015-06-30T20:24:06Z
dc.date2015-11-26T14:48:53Z
dc.date2015-06-30T20:24:06Z
dc.date2015-11-26T14:48:53Z
dc.date.accessioned2018-03-28T21:59:45Z
dc.date.available2018-03-28T21:59:45Z
dc.identifier
dc.identifierBiochemistry Research International. , v. , n. , p. - , 2011.
dc.identifier20902247
dc.identifier10.1155/2011/373859
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79959272009&partnerID=40&md5=865e52dbb3ad4b9a5278232336a42e72
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107800
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107800
dc.identifier2-s2.0-79959272009
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253736
dc.descriptionAlpha-hemoglobin-stabilizing protein (AHSP) is an erythroid-specific protein that acts as a molecular chaperone for the free chains of hemoglobin. Evidence strongly suggests that AHSP participates in hemoglobin synthesis and may act to neutralize the cytotoxic effects of excess free alpha-globin subunits that accumulate both in normal and beta-thalassemic erythroid precursor cells. As such, AHSP seems to be essential for normal erythropoiesis, and impaired upregulation of AHSP may lead to premature erythroid cell death, resulting in ineffective erythropoiesis. Reduced AHSP mRNA expression has been associated with clinical variability in some cases of β-thalassemia. It has been shown that Hb variants may also impair AHSP-αHb interactions, leading to pathological conditions that resemble α-thalassemia syndromes. The aim of this paper is to summarize current information concerning the structure and function of AHSP, focusing on its role in normal erythropoiesis and its relevance in health and disease. Copyright © 2011 Maria Emlia Favero and Fernando Ferreira Costa.
dc.description
dc.description
dc.description
dc.description
dc.descriptionLaskey, R.A., Honda, B.M., Mills, A.D., Finch, J.T., Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA (1978) Nature, 275 (5679), pp. 416-420
dc.descriptionEllis, J., Proteins as molecular chaperones (1987) Nature, 328 (6129), pp. 378-379
dc.descriptionEllis, R.J., Molecular chaperones: Assisting assembly in addition to folding (2006) Trends in Biochemical Sciences, 31 (7), pp. 395-401. , DOI 10.1016/j.tibs.2006.05.001, PII S0968000406001228
dc.descriptionEllis, R.J., Henderson, B., Pockley, A.G., Molecular chaperones: The orthodox view (2005) Molecular Chaperones and Cell Signalling, pp. 3-21. , New York, NY, USA Cambridge University Press
dc.descriptionGell, D., Kong, Y., Eaton, S.A., Weiss, M.J., MacKay, J.P., Biophysical characterization of the -globin binding protein-hemoglobin stabilizing protein (2002) Journal of Biological Chemistry, 277 (43), pp. 40602-40609
dc.descriptionKihm, A.J., Kong, Y., Hong, W., Russell, J.E., Rouda, S., Adachl, K., Simon, M.C., Weiss, M.J., An abundant erythroid protein that stabilizes free α-haemoglobin (2002) Nature, 417 (6890), pp. 758-763. , DOI 10.1038/nature00803
dc.descriptionDos Santos, C.O., Duarte, A.S.S., Olalla Saad, S.T., Costa, F.F., Expression of α-hemoglobin stabilizing protein gene during human erythropoiesis (2004) Experimental Hematology, 32 (2), pp. 157-162. , DOI 10.1016/j.exphem.2003.11.002
dc.descriptionKong, Y., Zhou, S., Kihm, A.J., Katein, A.M., Yu, X., Gell, D.A., Mackay, J.P., Weiss, M.J., Loss of α-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia (2004) Journal of Clinical Investigation, 114 (10), pp. 1457-1466. , DOI 10.1172/JCI200421982
dc.descriptionLai, M.I., Jiang, J., Silver, N., Best, S., Menzel, S., Mijovic, A., Colella, S., Thein, S.L., α-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of β-thalassaemia (2006) British Journal of Haematology, 133 (6), pp. 675-682. , DOI 10.1111/j.1365-2141.2006.06075.x
dc.descriptionDos Santos, C.O., Zhou, S., Secolin, R., Wang, X., Cunha, A.F., Higgs, D.R., Kwiatkowski, J.L., Weiss, M.J., Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function (2008) American Journal of Hematology, 83 (2), pp. 103-108
dc.descriptionWeiss, M.J., Zhou, S., Feng, L., Gell, D.A., Mackay, J.P., Shi, Y., Gow, A.J., Role of alpha hemoglobin-stabilizing protein in normal erythropoiesis and β-thalassemia (2005) Annals of the New York Academy of Sciences, 1054, pp. 103-117. , DOI 10.1196/annals.1345.013
dc.descriptionBunn, H.F., Forget, B.G., (1986) Hemoglobin: Molecular, Genetic and Clinical Aspects, , Philadelphia, Pa, USA WB Saunders
dc.descriptionBrunori, M., Falcioni, G., Fioretti, E., Giardina, B., Rotilio, G., Formation of superoxide in the autoxidation of the isolated and chains of human hemoglobin and its involvement in hemichrome precipitation (1975) European Journal of Biochemistry, 53 (1), pp. 99-104
dc.descriptionWeatherall, D.J., Thalassaemia: The long road from bedside to genome (2004) Nature Reviews Genetics, 5 (8), pp. 625-631. , DOI 10.1038/nrg1406
dc.descriptionRachmilewtiz, E., Schrier, S.L., Steinberg, M.H., Forget, B.G., Higgs, D.R., Nagel, R.L., Pathophysiology of -thalassemia (2001) Disorders of Hemoglobin: Genetics, Pathophysiology and Clinical Management, pp. 233-252. , New York, NY, USA Cambridge University Press
dc.descriptionDessypris, E.N., Sawyer, S.T., Greer, J.P., Foerster, J., Rodgers, G.M., Erythropoiesis (2008) Wintrobes Clinical Hematology, pp. 107-126. , 12th
dc.descriptionWeatherall, D.J., The genetic control of protein synthesis: The haemoglobin model (1974) Journal of Clinical Pathology. Supplement, 8, pp. 1-11
dc.descriptionMiele, G., Manson, J., Clinton, M., A novel erythroid-specific marker of transmissible spongiform encephalopathies (2001) Nature Medicine, 7 (3), pp. 361-363. , DOI 10.1038/85515
dc.descriptionPinho, F.O., De Albuquerque, D.M., Olalla Saad, S.T., Costa, F.F., Reduction of AHSP synthesis in hemin-induced K562 cells and EPO-induced CD34 cells leads to -globin precipitation, impairment of normal hemoglobin production, and increased cell death (2008) Experimental Hematology, 36 (3), pp. 265-272
dc.descriptionFeng, L., Gell, D.A., Zhou, S., Gu, L., Kong, Y., Li, J., Hu, M., Shi, Y., Molecular mechanism of AHSP-mediated stabilization of α-hemoglobin (2004) Cell, 119 (5), pp. 629-640. , DOI 10.1016/j.cell.2004.11.025, PII S0092867404010438
dc.descriptionFeng, L., Zhou, S., Gu, L., Gell, D.A., Mackay, J.P., Weiss, M.J., Gow, A.J., Shi, Y., Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem (2005) Nature, 435 (7042), pp. 697-701. , DOI 10.1038/nature03609
dc.descriptionYu, X., Kong, Y., Dore, L.C., Abdulmalik, O., Katein, A.M., Zhou, S., Choi, J.K., Weiss, M.J., An erythroid chaperone that facilitates folding of α-globin subunits for hemoglobin synthesis (2007) Journal of Clinical Investigation, 117 (7), pp. 1856-1865. , http://www.jci.org/cgi/reprint/117/7/1856, DOI 10.1172/JCI31664
dc.descriptionGallagher, P.G., Liem, R.I., Wong, E., Weiss, M.J., Bodine, D.M., GATA-1 and Oct-1 are required for expression of the human α-hemoglobin-stabilizing protein gene (2005) Journal of Biological Chemistry, 280 (47), pp. 39016-39023. , DOI 10.1074/jbc.M506062200
dc.descriptionHodge, D., Coghill, E., Keys, J., Maguire, T., Hartmann, B., McDowall, A., Weiss, M., Perkins, A., A global role for EKLF in definitive and primitive erythropoiesis (2006) Blood, 107 (8), pp. 3359-3370
dc.descriptionKeys, J.R., Tallack, M.R., Hodge, D.J., Cridland, S.O., David, R., Perkins, A.C., Genomic organisation and regulation of murine alpha haemoglobin stabilising protein by erythroid Kruppel-like factor (2007) British Journal of Haematology, 136 (1), pp. 150-157. , DOI 10.1111/j.1365-2141.2006.06381.x
dc.descriptionPilon, A.M., Nilson, D.G., Zhou, D., Sangerman, J., Townes, T.M., Bodine, D.M., Gallagher, P.G., Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Krüppel-like factor-deficient mice (2006) Molecular and Cellular Biology, 26 (11), pp. 4368-4377. , DOI 10.1128/MCB.02216-05
dc.descriptionViprakasit, V., Tanphaichitr, V.S., Chinchang, W., Sangkla, P., Weiss, M.J., Higgs, D.R., Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with β thalassemia (2004) Blood, 103 (9), pp. 3296-3299. , DOI 10.1182/blood-2003-11-3957
dc.descriptionDos Santos, C.O., Dore, L.C., Valentine, E., Shelat, S.G., Hardison, R.C., Ghosh, M., Wang, W., Weiss, M.J., An iron responsive element-like stem-loop regulates -hemoglobin- stabilizing protein mRNA (2008) Journal of Biological Chemistry, 283 (40), pp. 26956-26964
dc.descriptionSantiveri, C.M., Perez-Canadillas, J.M., Vadivelu, M.K., Allen, M.D., Rutherford, T.J., Watkins, N.A., Bycroft, M., NMR structure of the α-hemoglobin stabilizing protein: Insights into conformational heterogeneity and binding (2004) Journal of Biological Chemistry, 279 (33), pp. 34963-34970. , DOI 10.1074/jbc.M405016200
dc.descriptionZhou, S., Olson, J.S., Fabian, M., Weiss, M.J., Gow, A.J., Biochemical fates of α hemoglobin bound to α hemoglobin-stabilizing protein AHSP (2006) Journal of Biological Chemistry, 281 (43), pp. 32611-32618. , http://www.jbc.org/cgi/reprint/281/43/32611, DOI 10.1074/jbc.M607311200
dc.descriptionMollan, T.L., Yu, X., Weiss, M.J., Olson, J.S., The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly (2010) Antioxidants Amp
dc.descriptionRedox Signaling, 12 (2), pp. 219-231
dc.descriptionBaudin-Creuza, V., Vasseur-Godbillon, C., Pato, C., Prehu, C., Wajcman, H., Marden, M.C., Transfer of human α- to β-hemoglobin via its chaperone protein: Evidence for a new state (2004) Journal of Biological Chemistry, 279 (35), pp. 36530-36533. , DOI 10.1074/jbc.M405389200
dc.descriptionVasseur-Godbillon, C., Hamdane, D., Marden, M.C., Baudin-Creuza, V., High-yield expression in Escherichia coli of soluble human -hemoglobin complexed with its molecular chaperone (2006) Protein Engineering, Design and Selection, 19 (3), pp. 91-97
dc.descriptionHamdane, D., Vasseur-Godbillon, C., Baudin-Creuza, V., Hoa, G.H.B., Marden, M.C., Reversible hexacoordination of α-Hemoglobin-stabilizing Protein (AHSP)/α-hemoglobin versus pressure: Evidence for protection of the α-chains by their chaperone (2007) Journal of Biological Chemistry, 282 (9), pp. 6398-6404. , http://www.jbc.org/cgi/reprint/282/9/6398, DOI 10.1074/jbc.M610543200
dc.descriptionWeatherall, D.J., Phenotype-genotype relationships in monogenic disease: Lessons from the thalassaemias (2001) Nature Reviews Genetics, 2 (4), pp. 245-255. , DOI 10.1038/35066048
dc.descriptionGalanello, R., Perseu, L., Giagu, N., Sole, G., AHSP expression in -thalassemia carriers with thalassemia intermedia phenotype (2003) Blood, 102. , abstract no. 1881
dc.descriptionCappellini, M.D., Refaldi, C., Bignamini, D., Molecular analysis of -hemoglobin stabilizing protein (AHSP) in Caucasian patients with different -thalassemia phenotype (2004) Blood, 104. , 29b
dc.descriptionDos Santos, C.O., Zhou, S., Albuquerque, D.M., A natural variant sequence in the AHSP gene may impact severity of -thalassemia (2005) Blood, 106. , abstract no. 3629
dc.descriptionWang, Z., Yu, W., Li, Y., Shang, X., Zhang, X., Xiong, F.U., Xu, X., Analysis of -hemoglobin-stabilizing protein (AHSP) gene as a genetic modifier to the phenotype of -thalassemia in Southern China (2010) Blood Cells, Molecules, and Diseases, 45 (2), pp. 128-132
dc.descriptionWang, B., Fang, Y., Guo, X., Ren, Z., Zhang, J., Transgenic human -hemoglobin stabilizing protein could partially relieve iVS-2-654-thalassemia syndrome in model mice (2010) Human Gene Therapy, 21 (2), pp. 149-156
dc.descriptionMai, A., Jelicic, K., Rotili, D., Di Noia, A., Alfani, E., Valente, S., Altucci, L., Migliaccio, G., Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia (2007) Molecular Pharmacology, 72 (5), pp. 1111-1123. , http://molpharm.aspetjournals.org/cgi/reprint/72/5/1111, DOI 10.1124/mol.107.036772
dc.descriptionPissard, S., Vasseur, C., Toutain, F., Instable -hemoglobin stabilizing protein as a cause of thalassemia: Proof of concept (2009) Blood, 114. , abstract no. 462
dc.descriptionBrillet, T., Baudin-Creuza, V., Vasseur, C., Domingues-Hamdi, E., Kiger, L., Wajcman, H., Pissard, S., Marden, M.C., -Hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSP (2010) Journal of Biological Chemistry, 285 (23), pp. 17986-17992
dc.descriptionTurbpaiboon, C., Limjindaporn, T., Wongwiwat, W., U-Pratya, Y., Siritanaratkul, N., Yenchitsomanus, P.-T., Jitrapakdee, S., Wilairat, P., Impaired interaction of α-haemoglobin-stabilising protein with α-globin termination mutant in a yeast two-hybrid system (2006) British Journal of Haematology, 132 (3), pp. 370-373. , DOI 10.1111/j.1365-2141.2005.05865.x
dc.descriptionVasseur-Godbillon, C., Marden, M.C., Giordano, P., Wajcman, H., Baudin-Creuza, V., Impaired binding of AHSP to α chain variants: Hb Groene Hart illustrates a mechanism leading to unstable hemoglobins with α thalassemic like syndrome (2006) Blood Cells, Molecules, and Diseases, 37 (3), pp. 173-179. , DOI 10.1016/j.bcmd.2006.09.002, PII S1079979606001951
dc.descriptionGiordano, P.C., Zweegman, S., Akkermans, N., Arkesteijn, S.G.J., Van Delft, P., Versteegh, F.G.A., Wajcman, H., Harteveld, C.L., The first case of Hb Groene Hart [α119(H2)Pro→Ser, CCT→TCT (α1)] homozygosity confirms that a thalassemia phenotype is associated with this abnormal hemoglobin variant (2007) Hemoglobin, 31 (2), pp. 179-182. , DOI 10.1080/03630260701289490, PII 778209068
dc.descriptionLacerra, G., Scarano, C., Musollino, G., Flagiello, A., Pucci, P., Carestia, C., Hb Foggia or α117(GH5)Phe→Ser: A new α2 globin allele affecting the αHb-AHSP interaction (2008) Haematologica, 93 (1), pp. 141-142. , DOI 10.3324/haematol.11789
dc.descriptionYu, X., Mollan, T.L., Butler, A., Gow, A.J., Olson, J.S., Weiss, M.J., Analysis of human globin gene mutations that impair binding to the hemoglobin stabilizing protein (2009) Blood, 113 (23), pp. 5961-5969
dc.descriptionVasseur, C., Domingues-Hamdi, E., Brillet, T., Marden, M.C., Baudin-Creuza, V., The -hemoglobin stabilizing protein and expression of unstable -Hb variants (2009) Clinical Biochemistry, 42 (18), pp. 1818-1823
dc.languageen
dc.publisher
dc.relationBiochemistry Research International
dc.rightsaberto
dc.sourceScopus
dc.titleAlpha-hemoglobin-stabilizing Protein: An Erythroid Molecular Chaperone
dc.typeArtículos de revistas


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