Artículos de revistas
Gemcitabine-related Thrombotic Microangiopathy: A Single-centre Retrospective Series
Registro en:
Journal Of Chemotherapy. Maney Publishing, v. 26, n. 3, p. 169 - 172, 2014.
1120009X
10.1179/1973947813Y.0000000122
2-s2.0-84900317996
Autor
Leal F.
Macedo L.T.
Carvalheira J.B.C.
Institución
Resumen
Introduction: Thrombotic microangiopathy (TMA) has been reported as a complication of chemotherapy. Many antineoplastic agents have been linked to TMA, gemcitabine being one of the most frequently cited as related to this syndrome. Methods: A retrospective search for chemotherapy-induced TMA cases among gemcitabine users in a single oncology centre from January 2009 to September 2012 was performed. Results: Three cases of gemcitabine-induced TMA were reported, from a total of 264 patients (incidence: 1.13%) who received the drug. From the three cases reported, two (66%) patients died as a consequence of the syndrome. Discussion: These findings are compatible with previous analyses, which report an incidence of gemcitabine-associated TMA ranging from 0.008 to 2.2% and mortality rates from 15 to 90%. Unlike previously reported, however, cumulative dose was not predictive of risk. Conclusion: Gemcitabine-induced TMA is an underdiagnosed condition characterized by high mortality rates. Attention should be called for a higher level of awareness to provide early diagnosis and proper treatment. © 2014 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia. 26 3 169 172 Zupancic, M., Shah, P.C., Shah-Khan, F., Gemcitabine-associated thrombotic thrombocytopenic purpura (2007) Lancet Oncol, 8, pp. 634-641 Lesesne, J.B., Rothschild, N., Erickson, B., Korec, S., Sisk, R., Keller, J., Cancer-associated hemolytic-uremic syndrome: Analysis of 85 cases from a national registry (1989) J Clin Oncol, 7, pp. 781-789 Sheldon, R., Slaughter, D., A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma (1986) Cancer, 58, pp. 1428-1436 Izzedine, H., Isnard-Bagnis, C., Launay-Vacher, V., Mercadal, L., Tostivint, I., Rixie, O., Gemcitabine-induced thrombotic microangiopathy: A systematic review (2006) Nephrol Dial Transplant, 21, pp. 3038-3045 Muller, S., Schutt, P., Bojko, P., Nowrousian, M.R., Hense, J., Seeber, S., Hemolytic uremic syndrome following prolonged gemcitabine therapy: Report of four cases from a single institution (2005) Ann Hematol, 84, pp. 110-114 Murrin, R.J., Murray, J.A., Thrombotic thrombocytopenic purpura: Aetiology, pathophysiology and treatment (2006) Blood Rev, 20, pp. 51-60 Moake, J., Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies (2009) Best Pract Res Clin Haematol, 22, pp. 567-576 Cantrell Jr., J.E., Phillips, T.M., Schein, P.S., Carcinoma-associated hemolytic-uremic syndrome: A complication of mitomycin C chemotherapy (1985) J Clin Oncol, 3, pp. 723-734 Proia, A.D., Harden, E.A., Silberman, H.R., Mitomycin-induced hemolytic-uremic syndrome (1984) Arch Pathol Lab Med, 108, pp. 959-962 Watson, P.R., Guthrie Jr., T.H., Caruana, R.J., Cisplatin-associated hemolytic-uremic syndrome Successful treatment with a staphylococcal protein A column (1989) Cancer, 64, pp. 1400-1403 Leach, J.W., Pham, T., Diamandidis, D., George, J.N., Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTPHUS) following treatment with deoxycoformycin in a patient with cutaneous T-cell lymphoma (Sezary syndrome): A case report (1999) Am J Hematol, 61, pp. 268-270 Snyder Jr., H.W., Mittelman, A., Oral, A., Messersschmidt, G.L., Henry, D.H., Korec, S., Treatment of cancer chemotherapyassociated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome by protein A immunoadsorption of plasma (1993) Cancer, 71, pp. 1882-1892 Flombaum, C.D., Mouradian, J.A., Casper, E.S., Erlandson, R.A., Benedetti, F., Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine (1999) Am J Kidney Dis, 33, pp. 555-562 Porta, C., Danova, M., Riccardi, A., Bobbio-Pallavicini, E., Ascari, E., Cancer chemotherapy-related thrombotic thrombocytopenic purpura: Biological evidence of increased nitric oxide production (1999) Mayo Clin Proc, 74, pp. 570-574 Oleksowicz, L., Bhagwati, N., Deleon-Fernandez, M., Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies (1999) Cancer Res, 59, pp. 2244-2250 Moake, J.L., Thrombotic microangiopathies (2002) N Engl J Med, 347, pp. 589-600 Humphreys, B.D., Sharman, J.P., Henderson, J.M., Clark, J.W., Marks, P.W., Rennke, H.G., Gemcitabine-associated thrombotic microangiopathy (2004) Cancer, 100, pp. 2664-2670 Lewin, S.N., Mutch, D.G., Whitcomb, B.P., Liapis, H., Herzog, T.J., Three cases of hemolytic uremic syndrome in ovarian cancer patients treated with combination gemcitabine and pegylated liposomal doxorubicin (2005) Gynecol Oncol, 97, pp. 228-233 Fung, M.C., Storniolo, A.M., Nguyen, B., Arning, M., Brookfield, W., Vigil, J., A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy (1999) Cancer, 85, pp. 2023-2032 de Smet, D., Jochmans, K., Neyns, B., Development of thrombotic thrombocytopenic purpura after a single dose of gemcitabine (2008) Ann Hematol, 87, pp. 495-496 Lyman, N.W., Michaelson, R., Viscuso, R.L., Winn, R., Mulgaonakar, S., Jacobs, M.G., Mitomycin-induced hemolyticuremic syndrome Successful treatment with corticosteroids and intense plasma exchange (1983) Arch Intern Med, 143, pp. 1617-1618 Gourley, B.L., Mesa, H., Gupta, P., Rapid and complete resolution of chemotherapy-induced thrombotic thrombocytopenic purpura/ hemolytic uremic syndrome (TTP/HUS) with rituximab (2010) Cancer Chemother Pharmacol, 65, pp. 1001-1004 Ruiz, I., Del Valle, J., Gomez, A., Gemcitabine and haemolyticuraemic syndrome (2004) Ann Oncol, 15, pp. 1575-1576 Pfister, C., Muller, S., Schutt, P., Bojko, P., Nowrousian, M.R., Hense, J., Seeber, S., Ann, M.T., Hemolytic uremic syndrome following prolonged gemcitabine therapy: Report of four cases from a single institution (2005) Hematol, 84 (2), pp. 110-114. , Ann Hematol. 2005;84:621-2 Citarrella, P., Gebbia, V., Teresi, M., Miceli, S., Sciortino, G., Vaglica, M., Hemolytic uremic syndrome after chemotherapy with gemcitabine and taxotere: A case report (2002) Anticancer Res, 22, pp. 1183-1185 Kasi, P.M., Thrombotic thrombocytopenic purpura and gemcitabine (2011) Case Rep Oncol, 4 (1), pp. 143-148 Graas, M.P., Houbiers, G., Demolin, G., Stultiens, A., Focan, C., Hemolytic uremic syndrome Induced by gemcitabine A poorly recognized complication? (2012) Rev Med Liege, 67 (12), pp. 644-648 Zemtsov, A., Omueti-Ayoade, K., Zemtsov, R., Yang, M., Livedo reticularis as an initial clinical manifestation of gemcitabineinduced hemolytic uremic syndrome (2012) J Dermatol, 39 (5), pp. 487-489