Frailty is a syndrome that leads to practical harm in the lives of elders, since it is related to increased risk of dependency, falls, hospitalization, institutionalization, and death. The objective of this systematic review was to identify the socio-demographic, psycho-behavioral, healthrelated, nutritional, and lifestyle factors associated with frailty in the elderly. A total of 4,183 studies published from 2001 to 2013 were detected in the databases, and 182 complete articles were selected. After a comprehensive reading and application of selection criteria, 35 eligible articles remained for analysis. The main factors associated with frailty were: age, female gender, black race/color, schooling, income, cardiovascular diseases, number of comorbidities/diseases, functional incapacity, poor self-rated health, depressive symptoms, cognitive function, body mass index, smoking, and alcohol use. Knowledge of the complexity of determinants of frailty can assist the formulation of measures for prevention and early intervention, thereby contributing to better quality of life for the elderly.30611431168Morley, J.E., Vellas, B., van Kan, G.A., Anker, S.D., Bauer, J.M., Bernabei, R., Frailty consensus: A call to action (2013) J Am Med Dir Assoc, 14, pp. 392-397Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C., Gottdiener, J., Frailty in older adults: Evidence for a phenotype (2001) J Gerontol a Biol Sci Med Sci, 56, pp. M146-M156Fried, L.P., Ferrucci, L., Darer, J., Williamson, J.D., Anderson, G., Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care (2004) J Gerontol a Biol Sci Med Sci, 59, pp. M255-M263da Saúde, M., (2006) Envelhecimento E Saúde Da Pessoa Idosa, , Brasília: Ministério da Saúde, (Cadernos de Atenção Básica, Normas e Manuais Técnicos, 19)Espinoza, S.E., Fried, L.P., Risk factors for frailty in the older adult (2007) Clin Geriatr, 15, p. 37Alves, L.C., Leimann, B.C.Q., Vasconcelos, M.E.L., Carvalho, M.S., Vasconcelos, A.G.G., Fonseca, T.C.O., A influência das doenças crônicas na capacidade funcional dos idosos do Município de São Paulo, Brasil (2007) Cad Saúde Pública, 23, pp. 1924-1930Rockwood, K., Mitnitski, A., Frailty in relation to the accumulationof deficits (2007) J Gerontol Med Sci, 62, pp. 722-727Levers, M.J., Estabrooks, C.A., Kerr, J.C.R., Factors contributing to frailty: Literature review (2006) J Adv Nurs, 56, pp. 282-291Kaiser, M.J., Bandinelli, S., Lunenfeld, B., Frailty and the role of nutrition in older people: A review of the current literature (2010) Acta Biomed, 81 (SUPPL. 1), pp. 37-45Orme, J., Reis, J., Herz, E., Factorial and discriminate validity of the Center for Epidemiological Studies depression (CES-D) scale (1986) J Clin Psychol, 42, pp. 28-33Taylor, H.L., Jacobs, D.R., Schucker, B., Knudsen, J., Leon, A.S., Debacker, G., A questionnaire for the assessment of leisure-time physical activities (1978) J Chronic Dis, 31, pp. 745-755Higgins, J.P.T., Altman, D.G., Chapter 8: Assessing risk of bias in included studies (2008) Cochrane Handbook For Systematic Reviews of Interventions, Version 5.0.1, , http://www.cochrane-handbook.org, In: Higgins JPT, Green S, editors, The Cochrane Collaboration, (accessed on 20/May/2013)Wells, G.A., Shea, B., O'Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P., (2013) The Newcastle-Ottawa Scale (NOS) For Assessing the Quality of Nonrandomised Studies In Meta-analyses, , http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp, (accesssed on 20/May/)Stang, A., Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses (2010) Eur J Epidemiol, 25, pp. 603-605Folstein, M.F., Folstein, S.E., McHugh, P.R., Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12, pp. 189-198Ávila-Funes, J.A., Helmer, C., Amieva, H., Barbergergateau, P., Le Goff, M., Ritchie, K., Frailty among community-dwelling elderly people in France: The three-city study (2008) J Gerontol a Biol Sci Med Sci, 63, pp. 1089-1096Michelon, E., Blaum, C., Semba, R.D., Xue, Q.L., Ricks, M.O., Fried, L.P., Vitamin and carotenoid status in older women: Associations with the frailty syndrome (2006) J Gerontol a Biol Sci Med Sci, 61, pp. 600-607Alcalá, M.V.C., Puime, A., Santos, M.T.S., Barral, A.G., Montalvo, J.I.G., Zunzunegui, M.V., Prevalencia de fragilidad en una población urbana de mayores de 65 años y su relación con comorbilidad y discapacidad (2010) Aten Primaria, 42, pp. 520-527Mulero, J., Zafrilla, P., Martinez-Cacha, A., Oxidative stress, frailty and cognitive decline (2011) J Nutr Health Aging, 15, pp. 756-760Karahalil, B., Bohr, V.A., Wilson diabetes mellitus. Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk (2012) Hum Exp Toxicol, 31, pp. 981-1005Cutler, R.G., Human longevity and aging: Possible role of reactive oxygen species (1991) Ann N Y Acad Sci, 621, pp. 1-28Pinheiro, R.S., Viacava, F., Travassos, C., Brito, A.S., Gênero, morbidade, acesso e utilização de services de saúde no Brasil (2002) Ciênc Saúde Coletiva, 7, pp. 687-707Fiorio, N.M., Flor, L.S., Padilha, M., Castro, D.S., Molina, M.C.B., Mortalidade por raça/cor: Evidências de desigualdades sociais em Vitória (ES), Brasil (2011) Rev Bras Epidemiol, 14, pp. 522-530Batista, L.E., Masculinidade, raça/cor e saúde (2005) Ciênc Saúde Coletiva, 10, pp. 71-80Hirsch, C., Anderson, M.L., Newman, A., Kop, W., Jackson, S., Gottdiener, J., The association of race with frailty: The Cardiovascular Health Study (2006) Ann Epidemiol, 16, pp. 545-553Masel, M.C., Graham, J.E., Reistetter, T.A., Markides, K.S., Ottenbacher, K.J., Frailty and health related quality of life in older Mexican Americans (2009) Health Qual Life Outcomes, 7, p. 70Newman, A.B., Gottdiener, J.S., McBurnie, M.A., Hirsch, C.H., Willem, J.K., Tracy, R., Associations of subclinical cardiovascular disease with frailty (2001) J Gerontol a Biol Sci Med Sci, 56, pp. M158-M166Chen, C.Y., Wu, S.C., Chen, L.J., Lue, B.H., The prevalence of subjective frailty and factors associated with frailty in Taiwan (2010) Arch Gerontol Geriatr, 50, pp. S43-S47Woods, N.F., Lacroix, A.Z., Gray, S.L., Aragaki, A., Cochrane, B.B., Brunner, R.L., Frailty: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study (2005) J Am Geriatr Soc, 53, pp. 1321-1330Chemin, S.S., Mura, J.D.P., (2007) Tratado De Alimentação, Nutrição E Dietoterapia, , São Paulo: RocaRoubenoff, R., Sarcopenic obesity. Does muscle loss cause fat gain? Lessons from rheumatoid arthritis and osteoarthritis (2000) Ann N Y Acad Sci, 904, pp. 553-557Jenkins, K.R., Obesity's effects on the onset of functional impairment among older adults (2004) Gerontologist, 44, pp. 206-216Blaum, C.S., Xue, Q.L., Michelon, E., Semba, R.D., Fried, L.P., The association between obesity and the frailty syndrome in older women: The Women's Health and Aging Studies (2005) J Am Geriatr Soc, 53, pp. 927-934Semba, R.D., Bartali, B., Zhou, J., Blaum, C., Ko, C.W., Fried, L.P., Low serum micronutrient concentrations predict frailty among older women living in the community (2006) J Gerontol a Biol Sci Med Sci, 61, pp. 594-599Chaves, P.H., Varadhan, R., Lipsitz, L.A., Stein, P.K., Windham, B.G., Tian, J., Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women (2008) J Am Geriatr Soc, 56, pp. 1698-1703Szanton, S.L., Allen, J.K., Seplaki, C.L., Bandeen-Roche, K., Fried, L.P., Allostatic load and frailty in the women's health and aging studies (2009) Biol Res Nurs, 10, pp. 248-256Chang, S.S., Weiss, C.O., Xue, Q.L., Fried, L.P., Patterns of comorbid inflammatory diseases in frail older women: The Women's Health and Aging Studies I and II (2010) J Gerontol a Biol Sci Med Sci, 65, pp. 407-413Szanton, S.L., Seplaki, C.L., Thorpe, R.J., Allen, J.K., Fried, L.P., Socioeconomic status is associated with frailty: The Women's Health and Aging Studies (2010) J Epidemiol Community Health, 64, pp. 63-67Alvarado, B.E., Zunzunegui, M.V., Béland, F., Bamvita, J.M., Life course social and health conditions linked to frailty in Latin American older men and women (2008) J Gerontol a Biol Sci Med Sci, 63, pp. 1399-1406Endeshaw, Y.W., Unruh, M.L., Kutner, M., Newman, A.B., Bliwise, D.L., Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort (2009) Am J Epidemiol, 170, pp. 193-202Ottenbacher, K.J., Graham, J.E., Al Snih, S., Raji, M., Samper-Ternent, R., Ostir, G.V., Mexican Americans and frailty: Findings from the hispanic established populations epidemiologic studies of the elderly (2009) Am J Public Health, 99, pp. 673-679Wu, I., Shiesh, S.C., Kuo, P.H., Lin, X.Z., High oxidative stress is correlated with frailty in elderly chinese (2009) J Am Geriatr Soc, 57, pp. 1666-1671Hubbard, R.E., Lang, I.A., Llewellyn, D.J., Rockwood, K., Frailty, body mass index, and abdominal obesity in older people (2010) J Gerontol a Biol Sci Med Sci, 65, pp. 377-381Syddall, H., Roberts, H.C., Evandrou, M., Cooper, C., Bergman, H., Sayer, A.A., Prevalence and correlates of frailty among community-dwelling older men and women: Findings from the Hertfordshire Cohort Study (2010) Age Ageing, 39, pp. 197-203Drey, M., Wehr, H., Wehr, G., Uter, W., Lang, F., Rupprecht, R., The frailty syndrome in general practitioner care (2011) Z Gerontol Geriatr, 44, pp. 48-54Giménez, P.J., Bravo, M.A.E., Orrio, C.N., Satorra, T.B., Criterios de fragilidad del adulto mayor (2011) Estudio piloto Aten Primaria, 43, pp. 190-196Garcia-Garcia, F.J., Avila, G.G., Alfaro-Acha, A., Andres, M.A., Aparicio, M.E., Aparicio, S.H., The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging (2011) J Nutr Health Aging, 15, pp. 852-856Hoeck, S., François, G., Geerts, J., Van der Heyden, J., Vandewoude, M., van Hal, G., Health-care and home-care utilization among frail elderly persons in Belgium (2012) Eur J Public Health, 22, pp. 671-677Danon-Hersch, N., Rodondi, N., Spagnoli, J., Santos-Eggimann, B., Prefrailty and chronic morbidity in the youngest old: An insight from the Lausanne cohort Lc65+ (2012) J Am Geriatr Soc, 60, pp. 1687-1694Lakey, S.L., Lacroix, A.Z., Gray, S.L., Borson, S., Williams, C.D., Calhoun, D., Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study (2012) J Am Geriatr Soc, 60, pp. 854-861Bastos-Barbosa, R.G., Ferriolli, E., Coelho, E.B., Moriguti, J.C., Nobre, F., Lima, N.K.C., Association of frailty syndrome in the elderly with higher blood pressure and other cardiovascular risk factors (2012) Am J Hypertens, 25, pp. 1156-1161Jürschik, P., Nunin, C., Botigué, T., Escobar, M.A., Lavedán, A., Viladrosa, M., Prevalence of frailty and factors associated with frailty in the elderly population of Lleida, Spain: The FRALLE survey (2012) Arch Gerontol Geriatr, 55, pp. 625-631Chang, Y.W., Chen, W.L., Lin, F.G., Fang, W.H., Yen, M.Y., Hsieh, C.C., Frailty and its impact on healthrelated quality of life: A cross-sectional study on elder community-dwelling preventive health service users (2012) PLoS One, 7, pp. e38079Sousa, A.C.P.A., Dias, R.C., Maciel, A.C.C., Guerra, R.O., Frailty syndrome and associated factors in community-dwelling elderly in Northeast Brazil (2012) Arch Gerontol Geriatr, 54, pp. e95-e101Neri, A.L., Yassuda, M.S., Fortes-Burgos, A.C.G., Mantovani, E.P., Arbex, F.S., Torres, S.V.S., Relationships between gender, age, family conditions, physical and mental health, and social isolation of elderly caregivers (2012) Int Psychogeriatr, 24, p. 472Schnittger, R.I., Walsh, C.D., Casey, A.M., Wherton, J.P., McHugh, J.E., Lawlor, B.A., Psychological distress as a key component of psychosocial functioning in community-dwelling older people (2012) Aging Ment Health, 16, pp. 199-207Casale-Martínez, R.I., Navarrete-Reyes, A.P., Ávila-Funes, J.A., Social determinants of frailty in elderly Mexican community-dwelling adults (2012) J Am Geriatr Soc, 60, pp. 800-802Macuco, C.R.M., Batistoni, S.S.T., Lopes, A., Cachioni, M., Falcão, D.V.S., Neri, A.L., Mini-Mental State Examination performance in frail, pre-frail, and nonfrail community dwelling older adults in Ermelino Matarazzo, São Paulo, Brazil (2012) Int Psychogeriatr, 24, pp. 1725-1731