Artículos de revistas
Phoneutria Nigriventer (armed Spider) Venom Induces Increased Vascular Permeability In Rat And Rabbit Skin In Vivo
Registro en:
Toxicon. , v. 30, n. 9, p. 1011 - 1016, 1992.
410101
10.1016/0041-0101(92)90045-7
2-s2.0-0026705279
Autor
Antunes E.
Marangoni R.A.
Brain S.D.
de Nucci G.
Institución
Resumen
The effect of intradermally injected Phoneutria nigriventer venom (PNV) on vascular permeability of both rat and rabbit skin has been investigated. Oedema formation was measured as the local extravascular accumulation at skin sites of intravenously injected 125I-human serum albumin. In both rat and rabbit PNV induced dose-dependent oedema which was greatly potentiated by the vasodilators calcitonin-gene-related peptide and prostaglandin E1. In rats, PNV-induced oedema was markedly reduced either by previous treatment of the animals with the histamine H1 antagonist mepyramine and the serotonin antagonist methysergide or when venom was dialysed, indicating a major role for histamine and serotonin. In rabbits, dialysis of the venom to remove histamine and serotonin did not reduce PNV-induced oedema, indicating presence of oedematogenic component(s) which are different from the amines histamine or serotonin. © 1992. 30 9 1011 1016 Antunes, Marangoni, Borges, Fontana, de Nucci, Pharmacological profile of Phoneutria nigriventer venom on rabbit vascular smooth muscle (1990) British Journal of Pharmacology, 101, p. 508P Brain, Williams, Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability (1985) Br. J. Pharmac., 86, pp. 855-860 Diniz, Cordeiro, Junior, Kelly, Fischer, Reiman, Oliveira, Richardson, The purification and amino acid sequence of the lethal neurotoxin Tx1 from the venom of the Brazilian ‘armed’ spider Phoneutria nigriventer (1990) FEBS Lett., 263, pp. 251-253 Entwistle, Johnstone, Medzihradszky, May, Isolation of a pure toxic polypeptide from the venom of the spider Phoneutria nigriventer and its neurophysiological activity on an insect femur preparation (1982) Toxicon, 20, pp. 1059-1067 Fontana, Vital-Brazil, Mode of action of Phoneutria nigriventer spider venom at the isolated phrenic nerve-diaphragm of the rat (1985) Braz. J. Med. Biol. Res., 18, pp. 557-565 Kaiser, The enzymatic activity of spider venom (1953) Mem. Inst. Butantan, 25, pp. 35-39 Lucas, Spiders in Brazil (1988) Toxicon, 26, pp. 759-772 Rezende, Jr, Cordeiro, Oliveira, Diniz, Isolation of neurotoxic peptides from the venom of the armed spider Phoneutria nigriventer (1991) Toxicon, 29, pp. 1225-1233 Schenberg, Pereira-Lima, Phoneutria nigriventer venom (1971) Pharmacology and biochemistry of its components, 3, pp. 279-297. , W. Bucherl, E.E. Buckley, Venomous Animals and their Venoms, Academic Press, New York Spector, Willoughby, Endogenous mediators of increased vascular permeability in inflammation (1968) The Pharmacology of Inflammation, pp. 22-54. , English Universities Press Ltd Vital-Brazil, Leite, Fontana, Modo de ação da peçonha da aranha armadeira, Phoneutria nigriventer (Keyserling, 1891), nas aurículas isoladas de cobaia (1988) Ciênc. Cult., S Paulo, 40, pp. 181-185 Williams, Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation (1979) Br. J. Pharmac., 65, pp. 517-524