Focal cortical dysplasia is the most common malformation in patients with intractable epilepsy. The segmentation of FCD lesions in MR-T1 images of the brain is a crucial step for treatment planning. In this work we present a new FCD segmentation technique based on analysis of texture asymmetry. This technique does not rely on template-based segmentation and is applicable to patients of any age, regardless of anatomic variations. We evaluated the method on 5 patients (aged 11y-51y), and obtained 100% detection rate and coverage of 76.9% of the lesional voxels. ©2007 IEEE. 424427Taylor, D.C., Falconer, M.A., Bruton, C.J., Corsellis, J.A., Focal dysplasia of the cerebral cortex in epilepsy (1971) J Neurol Neurosurg Psychiatry, 34 (4), pp. 369-387. , AugFrater, J.L., Prayson, R.A., Morris III, H.H., Bingaman, W.E., Surgical pathologic findings of extratemporal-based intractable epilepsy (2000) Arch Pathol Lab Med, 124 (4), pp. 545-549. , AprColombo, N., Tassi, L., Galli, C., Citterio, A., Lo Russo, G., Scialfa, G., Spreafico, R., Focal cortical dysplasias: MR imaging, histopathologic, and clinical correlations in surgically treated patients with epilepsy (2003) Amer. J of Neuroradiology, 24, pp. 724-733. , AprRuggieri, P.M., Najm, I., Bronen, R., Campos, M., Cendes, F., Duncan, J.S., Weiser, H.G., Theodore, W.H., Neuroimaging of the cortical dysplasias (2004) Neurology, 62, pp. S27-S29Palmini, A., Andermann, F., Olivier, A., Tampieri, D., Robitaille, Y., Andermann, E., Wright, G., Focal neuronal migration disorders and intractable partial epilepsy: A study of 30 patients (1991) Annals of Neurology, 30 (6), pp. 741-749. , DecSisodiya, S.M., Surgery for malformations of cortical development causing epilepsy (2000) Brain, 123 (6), pp. 1075-1091. , JunLiu, S., An, N., Yang, H., Yang, M., Hou, Z., Liu, L., Liu, Y., Pediatric intractable epilepsy syndromes: Reason for early surgical intervention (2007) Brain & Development, 29 (2), pp. 69-78. , MarMontenegro, M.A., Li, L.M., Guerreiro, M.M., Guerreiro, C.A.M., Cendes, F., Focal cortical dysplasia: Improving diagnosis and localization with magnetic resonance imaging multiplanar and curvilinear reconstruction (2002) J Neuroimg, 12 (3), pp. 224-230. , JulBastos, A.C., Comeau, R.M., Andermann, F., Melanson, D., Cendes, F., Dubeau, F., Fontaine, S., Olivier, A., Diagnosis of subtle focal dysplastic lesions: Curvilinear reformatting from three-dimensional magnetic resonance imaging (1999) Annals of Neurology, 46 (1), pp. 88-94Bergo, F.P.G., Falcão, A.X., Fast and automatic curvilinear reformatting of MR images of the brain for diagnosis of dysplastic lesions (2006) Proc. 3rd Intl. Symp. on Biomed. Imaging, pp. 486-489. , Apr, IEEEKassubek, J., Huppertz, H.J., Spreer, J., Schulze-Bonhage, A., Detection and localication of focal cortical dysplasia by voxel-based 3-D MRI analysis (2002) Epilepsia, 43 (6), pp. 596-602. , JunAntel, S.B., Collins, D.L., Bernasconi, N., Andermann, F., Shinghal, R., Kearney, R.E., Arnold, D.L., Bernasconi, A., Automated detection of focal cortical dysplasia lesions using computational models of their MRI characteristics and texture analysis (2003) NeuroImage, 19 (4), pp. 1748-1759. , AugSrivastava, S., Maes, F., Vandermeulen, D., van Paesschen, W., Dupont, P., Suetens, P., Feature-based statistical analysis of structural MR data for automatic detection of focal cortical dysplastic lesions (2005) NeuroImage, 27 (2), pp. 253-266. , AugColliot, O., Mansi, T., Bernasconi, N., Naessens, V., Klironomos, D., Bernasconi, A., Segmentation of focal cortical dysplasia lesions on MRI using level set evolution (2006) NeuroImage, 32 (4), pp. 1621-1630. , OctCollins, D.L., Ziljdenbos, A.P., Kollokian, V., Sled, J.G., Kabani, N.J., Holmes, C.J., Evans, A.C., Design and construction of a realistic digital brain phantom (1998) IEEE Trans Medical Imaging, 17 (3), pp. 463-468. , JunCuadra, M.B., Pollo, C., Bardera, A., Cuisenaire, O., Villemure, J.-G., Thiran, J.-P., Atlas-based segmentation of pathologicalMRbrain images using amodel of lesion growth (2004) IEEE Trans Medical Imaging, 23 (10), pp. 1301-1314. , OctF. P. G. Bergo, G. C. S. Ruppert, L. F. Pinto, and A. X. Falcão, Fast and robust mid-sagittal plane location in 3D MR images of the brain, in Proc. BIOSIGNALS 2008 - Intl. Conf. on Bio-Inspired Syst. and Sig. Proc., Jan 2008, pp. 92-99Bergo, F.P.G., Falcão, A.X., Miranda, P.A.V., Rocha, L.M., Automatic image segmentation by tree pruning (2007) J Math Imaging and Vision, 29 (2-3), pp. 141-162. , NovHaralick, R., Shanmugam, K., Dinstein, I., Texture parameters for image classification (1973) IEEE Trans. Syst. Man Cyb, 3, pp. 610-621Duda, R.O., Hart, P.E., Stork, D.G., (2000) Pattern Classification, , Wiley-Interscience, 2nd edition