Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).444749754ALMEIDA, A.E., FERREIRA, A.G., CRESPI, M.S., ANDRADE, Z.A., CHUNG, M.C., Synthesis and thermal study of prodrug of oxamniquine (2006) J. Therm. Anal. Calorim, 83 (2), pp. 277-281AMARAL, R.S., PORTO, M.A.S., Evolução e situação do controle da esquistossomose no Brasil. (1994) Rev. Soc. Bras. Med. Trop, 27 (2), pp. 73-90BARBERATO-FILHO, S., ARGIONI, C., PINTO, C.P.L.S., CHIODELLI, S.G., VELLOSA, S.A.G., SILVA, R.M., SILVEIRA, M.A.B., Synthesis and evaluation of new oxamniquine derivatives (2002) Int. J. Pharm, 233 (1-2), pp. 35-41BUNDGAARD, H., Novel chemical approaches in prodrug design (1991) Drugs Fut, 16 (5), pp. 443-458BURGER, A., The conceptual background and development of medicinal chemistry (1995) Burger's Medicinal Chemistry and Drug Discovery: Principles and Practice, 1, pp. 1-8. , WOLFF, M. E, Ed, John Wiley & Sons: New YorkCARVALHO, E.M., ACIOLI, M.D., BRANCO, M.A.F., COSTA, A.M., CESSE, E.A.P., ANDRADE, A.G., MELLO, E.M.L.L., Evolução da esquistossomose na Zona da Mata Sul de Pernambuco. Epidemiologia e situação atual: Controle ou descontrole? (1998) Cad. Saúde Pública, 14 (4), pp. 787-795CDC. Health and Safety Topics, Atlanta, G.A.: U.S. Department of health and Human Services, CDC, 2007. Disponível em: 〈http://www.cdc.gov/ default.htm.〉. Acesso em: 20 de out. 2007CHUNG, M.C., FERREIRA, E.I., O processo de latenciação no planejamento de fármacos. (1999) Quim. Nova, 22 (1), pp. 75-84CIOLI, D., PICA-MATTOCCIA, L., ARCHER, S., Drug resistance in schistosomes (1993) Parasitol. Today, 9 (5), pp. 162-166EL-HAMOULY, W., PICA-MATTOCIA, L., CIOLI, D., SCHWARTZ, H.M., ARCHER, S., Studies on some derivatives of oxamniquine (1988) J. Med. Chem, 31 (8), pp. 1629-1631KATZ, N., PELLEGRINO, J., MEMORIA, J.M.P., Quantitative oogram method in Cebus monkeys experimentally infected with Schistosoma mansoni (1972) J. Parasitol, 52 (5), pp. 917-919MERCK index. 14.ed. Whitehouse Station, 2006. p.1192OLIVIER, L., STIREWALT, M.A., An efficient meted for exposure of mice to cercarie of Schistosoma mansoni (1952) J. Parasitol, 38, pp. 19-23(1994) Technical Reports Series, O Controle da Esquistossomose, 830. , ORGANIZAÇÃO MUNDIAL DE SAÚDE, Segundo Relatório do Comitê de Especialistas da OMS. Rio de Janeiro: Editora Fiocruz. 110pPARISE-FILHO, R., ARAÚJO, A.A.S., SANTOS-FILHO, M., MATOS, J.R., SILVEIRA, M.A.B., BRANDT, C.A., Thermoanalytical characterization of potentially schistosomicide polymeric derivatives (2004) J. Therm. Anal. Calorim, 75 (2), pp. 487-494REY, L., Esquistossomíase Mansônica, I., Bases da Parasitologia Médica (2002) 3 aed, pp. 413-443. , Rio de Janeiro: Guanabara KooganSHEKHAR, K.C., Schistosomiasis drug therapy and treatment consideration (1991) Drugs, 42 (3), pp. 379-405WORLD HEALTH ORGANIZATION. WHO, 2006. Schistosomiasis and intestinal parasites control. Planning and technical guidance. Communicable diseases prevention and control. Disponível em: 〈http://www.WHO.Ch./cds. 〉. Acesso em: 16 de out. 2006YOLLES, T.K., MOORE, P.V., DE GINSTI, D.L., RIPSON, C.A., MELENEY, H.E., A technique for the perfusion of laboratory animals for the recovery of schistosomes (1947) J. Parasitol, 33, pp. 419-426