Artículos de revistas
Importance Of Regulatory Cytokine Gene Polymorphisms In Hematopoietic Stem Cell Transplantation [importância De Polimorfismos De Genes Reguladores De Citocinas Em Transplantes De Células Progenitoras Hematopoiéticas]
Registro en:
Revista Brasileira De Ciencias Farmaceuticas/brazilian Journal Of Pharmaceutical Sciences. , v. 44, n. 4, p. 739 - 748, 2008.
15169332
10.1590/S1516-93322008000400021
2-s2.0-59649125596
Autor
Visentainer J.E.L.
Sell A.M.
Franceschi D.A.
Lieber S.R.
De Souza C.A.
Institución
Resumen
HLA genetic matching of donor and recipient is an important requirement for optimizing outcome following hematopoietic stem cell transplantation (HSCT). However, other non-HLA genes are being investigated for their role in graft-versus-host disease incidence and severity and in survival, by modulating the intensity of inflammation and tissue injury. These non-HLA-encoded genes include cytokine genes with polymorphisms within the 5' or 3' regulatory sequences of the genes. The polymorphisms or microsatellites may alter the transcription factor binding sites within the gene promoters and the amount of cytokine produced. 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