Artículos de revistas
Stathmin 1 In Normal And Malignant Hematopoiesis
Registro en:
Bmb Reports. The Biochemical Society Of The Republic Of Korea, v. 47, n. 12, p. 660 - 665, 2014.
19766696
10.5483/BMBRep.2014.47.12.020
2-s2.0-84922274764
Autor
Machado-Neto J.A.
Saad S.T.O.
Traina F.
Institución
Resumen
Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. 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