Artículos de revistas
Candida Colonization And Species In Patients Submitted To Head And Neck Radiotherapy [colonização E Espécies De Candida Em Pacientes Submetidos à Radioterapia Cervicofacial]
Registro en:
Jornal Brasileiro De Patologia E Medicina Laboratorial. , v. 43, n. 6, p. 407 - 412, 2007.
16762444
10.1590/S1676-24442007000600004
2-s2.0-41549132300
Autor
Bonan P.R.F.
Pires F.R.
Lopes M.A.
Di Hipolito Jr. O.
Institución
Resumen
The aims of this study were to investigate Candida carriage associated with reduced salivary flow and to identify Candida species in 20 patients with squamous cell carcinoma before, during and after head and neck radiotherapy, comparing with 2 control groups, one compounded by 24 healthful patients and the other, by nine patients submitted to head and neck radiotherapy one year at least. Whole non stimulated saliva were collected from all patients. Candida unit form colonies were quantified and identified using biochemistry tests, CHROMagar and API 20 Aux. The results showed progressive reduction of salivary flow during radiotherapy (p = 0.001) and increased Candida carriage, mainly C. tropicalis and C. albicans, with species diversification. The correlation between reduced salivary flow and increased Candida carriage was statistically demonstrated (p = 0.009). After 12 months of the radiotherapy, the patients showed higher incidence of C. albicans and C. tropicalis. In conclusion, head and neck irradiated patients showed reduced salivary flow during radiotherapy, increasing of Candida colonization and higher variety of Candida species on saliva than non irradiated patients during and after radiotherapy. 43 6 407 412 ALMSTAHL, A., WISKTROM, M., Oral microflora in subjects with reduced salivary secretion (1999) J Dent Res, 78, pp. 1410-1416 BELAZI, M., Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: Prevalence, azole susceptibility profiles and response to antifungal treatment (2004) Oral Microbiol Immunol, 19, pp. 347-351 BLOZIS, G.G., ROBINSON, J.E., Oral tissues changes caused by radiation therapy and their management (1968) Dent Clin North Am, s/n, pp. 643-656 BONAN, P.R., Evaluation of salivary flow in patients during head and neck radiotherapy (2003) Pesqui Odontol Bras, 17, pp. 156-160 BUDTZ-JÖRGENSEN, E., The significance of Candida albicans in denture stomatitis (1974) Scand J Dent Res, 82, pp. 151-190 BUDTZ-JÖRGENSEN, E., STENDERUP, A., GRABOWSKY, M., An epidemiological study of yeast in elderly denture wearers (1975) Community Dent Oral Epidemiol, 3, pp. 115-119 CARL, W., Local radiation and systemic chemotherapy: Preventing and managing the oral complications (1993) J Am Dent Assoc, 124, pp. 119-123 DAHIYA, M.C., Oropharyngeal candidiasis caused by non-albicans yeast in patients receiving external beam radiotherapy for head-and-neck cancer (2003) Int J Radiat Oncol Biol Phys, 57, pp. 79-83 EPSTEIN, J.B., Quality of life and oral function following radiotherapy for head and neck cancer (1999) Head Neck, 21, pp. 1-11 EPSTEIN, J.B., FREILICH, M.M., LE, N.D., Risk factors for oropharyngeal candidiasis in patients who receive radiation therapy for malignant conditions of the head and neck (1993) Oral Surg Oral Med Oral Pathol, 76, pp. 167-174 GARG, A.K., MALO, M., Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy (1997) J Am Dent Assoc, 128, pp. 1128-1133 GROTZ, K.A., Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy (2003) Support Care Cancer, 11, pp. 717-721 LEUNG, W.K., Oral colonization, phenotypic and genotypic profiles of Candida species in irradiated, dentate, xerostomic, nasopharyngeal carcinoma survivors (2000) J Clin Microbiol, 38, pp. 2219-2226 LOPES, M.A., Reconhecendo e controlando os efeitos colaterais da radioterapia. (1998) Revista da APCD, 241 -4 LOPEZ-JORNET, M.P., BERMEJO-FENOLL, A., Is there an aged-dependent decrease in resting secretion of saliva of healthy person? A study of 1493 subjects (1994) Braz Dent J, 5, pp. 93-98 OLSEN, I., STENDERUP, A., Clinical-mycologic diagnosis of oral yeast infections (1990) Acta Odontol Scand, 48, pp. 11-18 PAULA, C.R., SAMPAIO, M.C.C., BIRMAN, E.G., SIQUEIRA, A.M., Oral yeasts in patients with cancer of the mouth, before and during radiotherapy (1990) Mycopathologia, 112, pp. 119-124 QUINDOS, G., Utility of fluoroplate Candida for the rapid identification of Candida albicans (1996) Enferm Infecc Microbiol Clin, 14, pp. 586-589 RAMIREZ-AMADOR, V., Candidal colonization and oral candidiasis in patient undergoing oral and pharyngeal radiation therapy (1997) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 84, pp. 149-153 REDDING, S.W., Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer (1999) J Clin Microbiol, 37, pp. 3896-3900 REGELINK, G., Efficacy of a synthetic polymer saliva substitute in reducing oral complaints of patients suffering from irradiation-induced xerostomia (1998) Quintessense Int, 29, pp. 383-388 ROSSIE, K.M., Influence of radiation therapy on oral Candida albicans colonization: A quantitative assessment (1987) Oral Surg Oral Med Oral Pathol, 64, pp. 698-701 ROTHWELL, B.R., Prevention and treatment of orofacial complications of radiotherapy (1987) J Am Dent Assoc, 114, pp. 316-322 SANDVEN, P., Laboratory identification and sensitivity testing of yeast isolates (1990) Acta Odontol Scand, 48, pp. 27-36 SCULLY, C., EPSTEIN, J.B., Oral health care for the cancer patient (1996) Eur J Cancer B Oral Oncol, 32 B, pp. 281-292 TARTARO, G.P., ITRO, A., GRISOLIA, G., Oral candidiasis following radiotherapy for neoplasms of oromaxillofacial area (1996) Minerva Stomatol, 45, pp. 451-454 WEERKAMP, A.H., Effect of the application of mucin-based saliva substitute on oral microflora of xerostomic patients (1998) J Oral Pathol, 16, pp. 474-478 WHITMYER, C.C., ESPOSITO, S.J., TEREZHALMY, G.T., Radiotherapy for head and neck neoplasm (1997) Gen Den, 45, pp. 363-370