Artículos de revistas
Levonorgestrel Plasma Levels During Continuous Administration With Different Models Of Subdermal Implants
Registro en:
Contraception. , v. 27, n. 2, p. 123 - 130, 1983.
107824
10.1016/0010-7824(83)90083-5
2-s2.0-0020583915
Autor
Alvarez F.
Brache V.
Faundes A.
Johansson E.D.B.
Odlind V.
Nash H.
Institución
Resumen
Plasma concentrations of levonorgestrel were determined in women using subdermal levonorgestrel implants. One group had 6 Silastic ® capsules† † Silastic® supplied by Leiras Pharmaceutical, Turku, Finland. (NORPLANT), one group had 4 and one group had 6 covered Silastic® rods for variable lengths of time. Levonorgestrel concentrations remained constant around 0.4 ng/ml up until 6 years of use in the Norplant group. The observation period was shorter for the covered rods; plasma concentrations were, however, constant around 0.55 ng/ml and 0.70 ng/ml for 3.5 years with the 4 rods and 6 covered rods, respectively. The difference in mean levonorgestrel concentrations between the three groups were statistically significant (p < 0.0005). Plasma levels of levonorgestrel were twice to three times higher in blood obtained from the arm with the implants compared to the levels found in the other arm. The application of a tourniquet for variable periods before blood sampling did not influence the plasma concentrations of levonorgestrel. © 1983. 27 2 123 130 Segal, Croxatto, Single administration of hormones for long-term control of reproductive function (1967) Presentation at the XXIII Meeting of the American Fertility Society, , April 14–16, Washington DC Alvarez, Robertson, Montes de Oca, Sivin, Brache, Faundes, Comparative clinical trial of the progestins R-2323 and levonorgestrel administered by subdermal implants (1978) Contraception, 18, pp. 151-162 Coutinho, da Silva, Mattos, Nielsen, Osler, Wiese, Holma, Sivin, Contraception with long acting subdermal implants. I. An effective and acceptable modality in international clinical trials (1978) Contraception, 18, pp. 315-333 Coutinho, da Silva, Mattos, Nielsen, Osler, Wiese, Holma, Sivin, Contraception with long acting subdermal implants. II. Measured and perceived effects in international clinical trials (1978) Contraception, 18, pp. 335-353 Faundes, Brache de Mejias, Leon, Robertson, Alvarez, First year clinical experience with six levonorgestrel rods as subdermal contraception (1979) Contraception, 20, pp. 167-175 Croxatto, Diaz, Miranda, Elamsson, Johansson, Plasma levels of levonorgestrel in women during long-term use of NORPLANT (1980) Contraception, 22, pp. 583-596 Weiner, Victor, Johansson, Plasma levels of d-norgestrel after oral administration (1976) Contraception, 14, pp. 563-570