Implantology had experienced a rapid evolution in the last 30 years and the use of biomaterials on tissue recuperation has been more frequent; for this reason it is necessary to know the repaired process and histological reaction between the hosted tissue and the biomaterials, thereby determining the success of the therapy in the long time. Clinically, it has been to possible to see the effects of different biomaterials, but after an histological analyses, has been demonstrated some variations that make them unaccepted for dental treatment. The aim of this review is to report the way of the bone cicatrisation with different biomaterials and the form in which it is developed this cicatrisation on the rehabilitation with implants with different load protocols.253649657Albrektsson, T., Bränemark, P.I., Hansson, H.A., Lindstrom, J., Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man (1981) Acta Orthop. Scand, 52 (2), pp. 155-170Akça, K., Akkocaoglu, M., Cömert, A., Tekdemir, I., Çehreli, M.C., Human ex vivo bone tissue strains around immediately loaded implants supporting maxillary overdentures (2005) Clin. Oral Impl. Res, 16, pp. 715-722Aparicio, C.Rangert, B. & Sennerby, L. Immediate/early loading of dental implants: a report from the Sociedad Espanola de Implantes World Congress consensus meeting in Barcelona, Spain. Clin. Implant Dent. Relat. Res., 5:57-60, 2003Armir, L.R., Becking, A.G., Jovanovic, A., Perdijk, F.B.T., Everts, V., Bronckers, A.L.J.J., Vertical distraction osteogenesis in the human mandible: A prospective morphometric study (2006) Clin. Oral Implants Res, 17, pp. 417-425Armir, L.R., Becking, A.G., Jovanovic, A., Perdijk, F.B.T., Everts, V., Bronckers, A.L.J.J., Formation of new bone during vertical distraction osteogenesis of the human mandible is related to the presence of blood vessels (2006) Clin. Oral Implants Res, 17, pp. 410-416Bränemark, P.I., Osseointegration and its experimental background (1983) J. Prosth. Dent, 50, pp. 399-410Brown, M.D., Hudlicka, O., Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: Involvement of VEGF and metalloproteinases (2003) Angiogenesis, 2003;6(1), pp. 1-14Canalis, E., McCarthy, T., Centrella, M., Growth factors and the regulation of bone remodeling (1988) J. Clin. Invest, 81, pp. 277-281Cecchinato, D., Olsson, C., Lindhe, J., Submerged or non - submerged healing of endosseous implants to be used in the rehabilitation of partially dentate patients (2004) J. Clin. Periodontol, 31, pp. 299-308Chiapasco, M., Gratti, C., Rossi, E., Haefliger, W., Markwalder, T.H., Implant-retained mandibular overdentures with immediate loading. A retrospective multicenter study on 226 consecutives cases (1997) Clin. Oral Impl. Res, 8, pp. 48-57Chiapasco, M., Gatti, C., Gatti, F., Immediate loading of dental implants placed in severely resorbed edentulous mandibles reconstructed with autogenous calvarial grafts (2007) Clin. Oral Impl. Res, 18, pp. 13-20Cochran, D., Morton, D., Weber, H.S., Consensus statements and recommended clinical procedures regarding loading protocols for endosseous dental implants (2004) Int. J. Oral Maxillofac. Implants, 19 (7), pp. 109-113Cortez, A.L.V., Rabelo, G.O., Mazzonetto, R., Reconstrução de maxila atrófica utilizando osso autógeno e malha de titânio para posterior reabilitação com implantes - caso clínico (2004) Rev. Port. Estomatol. Med. Dent. e Cir. Maxilofac, 45 (3), pp. 163-167Degidi, M., Artese, L., Rubini, C., Perrotti, V., Iezzi, G., Piattelli, A., Microvessel density and vascular endothelial growth factor expression in sinus augmentation using Bio-Oss® (2005) Oral Disease, 12, pp. 469-475Degidi, M., Piattelli, A.A., 7-year follow-up of 93 immediately loaded titanium dental implants (2005) J. Oral Implants, 31 (1), pp. 25-31Ericsson, I., Nilson, H., Lindh, T., Nilner, K., Randow, K., Immediate functional loading of Bränemark single tooth implants. An 18 month's clinical pilot follow-up study (2000) Clin. Oral Impl. Res, 11, pp. 26-33Froum, S., Cho, S.C., Elian, N., Rosenberg, E., Rohrer, M., Tarnow, D., Extraction sockets and implantation of hydroxyapatites with membrane barriers. A histologic study (2004) Implant. Dent, 13, pp. 153-164Gapski, R., Wang, H.L., Mascarenhas, P., Lang, N.P., Critical review of immediate implant loading (2003) Clin. Oral Impl. Res, 14, pp. 515-527Grageda, E., Platelet-rich plasma and bone grafo materials: A review and standardized research protocol (2004) Implant Dent, 13, pp. 301-309Gruber, R., Baron, M., Busenlechner, D., Kandler, B., Fuerst, G., Watzek, G., Proliferation and osteogenic differentiation of cells from cortical bone cylinders, bone particles from mill, and drilling dust (2005) J. Oral Maxillofac. Surg, 63, pp. 238-243Hanson, S., Werke, M., The implant thread as a retention element in cortical bone: The effect of thread size and thread profile: a finite element study (2003) J. Biomechanics, 36, pp. 1247-1258Hing, K.A., Wilson, L.F., Buckland, T., Comparative performance of three ceramic bone graft substitutes (2007) The Spine Journal, , in pressHobkirk, J.A., Wiskott, H.W.A., Biomechanical aspects of oral implants. Consensus report of working group I (2006) Clin. Oral Impl. Res, 17 (SUPPL. 2), pp. 52-54Horiuchi, N., Maeda, T., Statins and bone metabolism (2006) Oral Diseases, 12, pp. 85-101Huang, Y.C., Kaigler, D., Rice, K., Krebsbach, P., Mooney, D., Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration (2005) J. Bone Miner. Res, 20, pp. 848-857Issa, M.J.P., Tiossi, R., Pitol, D.L., Mello, S.A., TGFb and new bone formation (2006) Int. J. Morphol, 24, pp. 339-405Issa, M.J.P., Nascimento, C., Barbosa, S.R.E., Mello, S.A., Iyomasa, M.M., Morphogenetic protein rhBMP-2 and new formation (2006) Int. J. Morphol, 24, pp. 323-330Jensen, S.S., Broggini, N., Hjorting-Hansen, E., Schenk, R., Buser, D., Bone healing and graft resorption of autograft, anorganic bovine bone and b-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs (2005) Clin. Oral Implant. Res, 17, pp. 237-243Kalmey, J.K., Lovejoy, C.O., Collagen fiber orientation in the femoral necks of apes and humans: Do their histological structures reflect differences in locomotor loading? (2002) Bone, 31, pp. 327-332Kawahara, H.Kawahara, D.Hayakawa, M.Tamai, Y.Kuremoto, T. & Matsuda, S. Osseointegration Ander immediate loading: biomechanical stress-strain and bone formation-resorption. Implant Dent., 12: 61-8, 2003Kleinheinz, J., Stratmann, U., Joos, U., Wiesmann, H.P., VEGF-Activated angiogenesis during bone regeneration (2005) J. Oral Maxillofac. Surg, 63, pp. 1310-1316Kübler, A., Neugebauer, J., Oh, J.H., Scheer, M., Zöller, J., Growth and proliferation of human osteoblasts on different bone graft substitutes. An in vitro study (2004) Implant Dent, 13, pp. 171-179Li, T.S., Hamano, K., Nishida, M., Hayashi, M., Ito, H., Mikamo, A., Matsuzaki, M., CD117+ stem cells play a key role in therapeutic angiogênese induced by boné marrow cell implantation (2003) Am. J. Physiol. Hearth. Circ. Physiol, 285, pp. 931-937Lienau, J., Schell, H., Duda, G., Seebeck, P., Muchow, S., Bail, H., Initial vascularization and tissue differentiation are influenced by fixation stability (2005) J. Orthopaedic Res, 23, pp. 639-645Liu, Y., Dulchavsky, D., Gao, X., Kwon, D., Chopp, M., Dulchavsky, S., Gautam, S., Wound repair by bone marrow stromal cells through growth factor production (2006) J. Surg. Res, 136, pp. 336-341Lorenzoni, M., Pertl, C., Zhang, K., Wimmer, G., Wegscheider, W.A., Immediate loading of single-tooth implants in the anterior maxilla. Preliminary results after one year (2003) Clin. Oral Impl. Res, 14, pp. 180-187Madeddu, P., Therapeutic angiogenesis and vasculogenesis for tissue regeneration (2005) Exp. Physiol, 90 (3), pp. 315-326McMillan, P.J., Riggs, M.L., Bogle, G., Crigger, M., Variables that influence the relationship between osseointegration and bone adjacent to an implant (2000) Int. J. Oral Maxillofac Implants, 15, pp. 654-661Meyer, U., Wiesmann, H.P., Fillies, T., Joos, U., Early tissue reaction at the interface of immediately loaded dental implants (2003) Int. J. Oral Maxillofac. Implants, 18, pp. 489-499Miura, M., Miura, Y., Sonoyama, W., Yamaza, T., Gronthos, S., Shi, S., Boné marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region (2006) Oral Disease, 12, pp. 514-522Moghadam, H., Sándor, G., Colmes, H., Clokie, C., Histomorphometric evaluation of bone regeneration using allogeneic and alloplastic boné substitutes (2004) J. Oral Maxillofac. Surg, 62, pp. 202-213Moore, W.R., Graves, S.E., Bain, G.I., Synthetic bone substitutes (2001) A. N. Z. J. Surg, 71, pp. 354-361Morton, D., Jaffin, R., Weber, H.P., Immediate restoration and loading of dental implants: Clinical considerations and protocols (2004) Int. J. Oral Maxillofac. Implants, 19 (SUPPL.), pp. 103-108Nishimura, I., Shimizu, Y., Ooya, K., Effects of cortical bone perforation on experimental guided bone regeneration (2004) Clin. Oral Implant. Res, 15, pp. 293-300Nkenke, E., Lehner, B., Weinzierl, K., Thams, U., Neugebauer, J., Steveling, H., Radespiel-Tröger, M., Neukam, F.W., Bone contact, growth, and density around immediately loaded implants in the mandible of mini pigs (2003) Clin. Oral Impl. Res, 14, pp. 312-321Nkenke, E., Lehner, B., Fenner, M., San Roman, F., Thams, U., Neukam, F.W., Radespiel-Tröger, M., Immediate versus delayed loading of dental implants in the maxillae of minipigs: Follow-up of implant stability and implant failures (2005) Int. J Oral Maxillofac. Implants, 20, pp. 39-47Nkenke, E., Fenner, M., Vairaktaris, E.G., Neukam, F.W., Radespiel-Tröger, M., Immediate versus delayed loading of dental implants in the maxillae of minipigs. Part II: Histomorphometric analysis (2005) Int. J. Oral Maxillofac. Implants, 20, pp. 540-546Nkenke, E., Fenner, M., Indications for immediate loading of implants and implant success (2006) Clin. Oral Impl. Res, 17 (SUPPL. 2), pp. 19-34Olate, S.Alister, J. P.Soto, M.Alveal, R.Fuentes, J. & Thomas, D. Extracciones e indicaciones de extracciones dentales en población rural chilena de 11 a 30 años. Av. Odontoestomatol., 22 (2):119-24, 2006Olmedo, D., Fernández, M.M., Guglielmotti, M.B., Cabrini, R.L., Macrophages related to dental implant failure (2003) Implant Dent, 12, pp. 75-80Ottoni, J.M.P., Oliveira, Z.F.L., Manzini, R., Cabral, A.M., Correlation between placement torque and survival of single-tooth implants (2005) Int. J. Oral Maxillofac. Implants, 20, pp. 769-776Petersen, P.E., Yamamoto, T., Improving the oral health of older people: The approach of the WHO Global Oral Health Programme (2005) Community Dent. Oral Epidemiol, 33, pp. 81-92Piattelli, A., Degidi, M., Di Stefano, D., Rubini, C., Fioroni, M., Strocchi, R., Microvessel density in alveolar ridge regeneration with autologous and alloplastic bone (2002) Implant Dent, 11 (4), pp. 370-375Queiroz, T.P., Hochuli-Vieira, E., Gabrielli, M.A.C., Cancian, D.C.J., Use of bovine graft and boné membrane in defects surgically created in the cranial vault of rabbits. Histologic comparative analysis (2006) Int. JRoethy, W.Fiehn, E.Suehiro, K.Gu, A.Hua, Yi, G.Shimizu, J.Wang, J.Zhang, G.Ranieri, J.Akella, R.Funk, S.Sage, H.Benedict, J. & Burkhoff, D. A growth factor mixture that significantly enhances angiogenesis in vivo. J. P. E. T., 299:494-500, 2001Rosenkilde, M., Schwartz, T., The chemokine system - a major regulator of angiogenesis in health and disease (2004) APMIS, 112, pp. 481-495Scarano, A.Degidi, M.Iezzi, G.Petrone, G. & Piattelli, A.Correlation between implant stability quotient and bone-implant contact: a retrospective histological and histomorphometrical study of seven titanium implants retrieved from humans. Clin. Implant Dent. Relat. Res. 8(4):218-22, 2006Schincaglia, G.P., Marzola, R., Scapoli, C., Scotti, R., Immediate loading of dental implants supporting fixed partial dentures in the posterior mandible: A randomized controlled split - mouth study - machined versus titanium oxide implant surface (2007) Int. J. Oral Maxillofac. Implants, 22, pp. 35-46Schroeder, A.Maeglin, B. & Sutter, F. Das ITIHohlzylinderimplantat Typ F zur Prothesenretention beim zahnlosen Kiefer. Schweizerische Monatschrift fur Zahnheilkunde. 93:720-33, 1983Schwarz, F., Rothamel, D., Herten, M., Sager, M., Becker, J., Angiogenesis pattern of native and cross-linked collagen membranes: An immunohistochemical study in the rat (2006) Clin. Oral Implant Res, 17, pp. 403-409Serra e Silva, F. M.Albergaria-Barbosa, J. R. & Mazzonetto, R. Clinical evaluation of association of bovine organic osseous matrix and bovine bone morphogenetic protein versus autogenous bone graft in sinus floor augmentation. J. Oral Maxillofac. Surg., 64:931-5, 2006Suba, Z., Takács, D., Matusovits, D., Barabás, J., Fazekas, A., Szabó, G., Maxillary sinus floor grafting with b-tricalcium phosphate in humans: Density and microarchitecture of the newly formed bone (2006) Clin. Oral Impl. Res, 17, pp. 102-108Szmukler-Moncler, S., Piatelli, A., Favero, G.A., Dubruille, J.H., Considerations preliminary to the application of early and immediate loading protocols in dental implantology (2000) Clin. Oral Impl. Res, 11, pp. 12-25Tamimi, F.M., Torres, J., Tresguerres, I., Clemente, C., López-Cabarcos, E., Blanco, L.J., Bone augmentation in rabbit calvariae: Comparative study between Bio-Oss® and a novel b-TCP/DCPD granulate (2006) J. Clin. Periodontol, 33, pp. 922-928Thorwarth, M., Schultze-Mosgau, S., Kessler, P., Wiltfang, J., Schlegel, K.A., Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite (2005) J. Oral Maxillofac. Surg, 63, pp. 1626-1633Traini, T., Degidi, M., Caputi, S., Strocchi, R., Di lorio, D., Piattelli, A., Collagen fiber orientation in human periimplant boné around immediately loaded and unloaded titanium dental implants (2005) J. Periodontol, 76, pp. 83-89Urist, M.R., Delange, J.R., Finerman, G.A.M., Bone cell diferentiation and growth factors (1983) Science, 220, pp. 680-686Wang, H.L., Ormianer, Z., Palti, A., Perel, M., Trisi, P., Sammartino, G., Consensus conference on immediate loading: The single tooth and partial edentulous areas (2006) Implant. Dent., 15, pp. 324-333Weiss, S., Zimmermann, G., Baumgart, R., Kasten, P., Bidlingmaier, M., Henle, P., Systemic regulation of angiogenesis and matrix degradation in bone regeneration - distraction osteogenesis compared to rigid fracture healing (2005) Bone, 37 (6), pp. 781-790Winet, H., The role of microvasculature in normal and perturbed bone healing as revealed by intravital microscopy (1996) Bone, 19 (SUPP 1), pp. 39S-57S