Artículos de revistas
Bacterial Chemistry-iii: Preliminary Studies On Trypanosomal Activities Of Chromobacterium Violaceum Products.
Registro en:
Anais Da Academia Brasileira De Ciencias. , v. 61, n. 1, p. 31 - 36, 1989.
13765
2-s2.0-0024624735
Autor
Duran N.
Campos V.
Riveros R.
Joyas A.
Pereira M.F.
Haun M.
Institución
Resumen
It has been found that the pigment-I from Chromobacterium violaceum, 3-[1,2-dihydro5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-yli diene] 1,3-dihydro-2H-indol-2-one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 microM after 48 h of interaction with a total growth inhibition in the same period. Pigment-I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound. 61 1 31 36