Artículos de revistas
Evaluation Of The Effects Of Anthocyanins In Type 2 Diabetes
Registro en:
Food Research International. , v. 46, n. 1, p. 378 - 386, 2012.
9639969
10.1016/j.foodres.2011.11.021
2-s2.0-84857648468
Autor
Sancho R.A.S.
Pastore G.M.
Institución
Resumen
The number of cases of type 2 diabetes (T2D) is increasing worldwide. This disease can be characterized by insulin resistance and pancreatic β cell dysfunction, which lead to macro- and microvascular complications. Anthocyanins are flavonoids that occur naturally in plants and are responsible for their color. Studies with cell lines and animal models and clinical trials in humans suggest that anthocyanins exhibit antidiabetic properties. However, variation in the structure of anthocyanins makes it difficult to determine their effects on T2D. Understanding the absorption and metabolism of anthocyanins is important for understanding their role in the improvement of this disease. Published data suggest that anthocyanins may lower blood glucose by improving insulin resistance, protecting β cells, increasing secretion of insulin and reducing digestion of sugars in the small intestine. The mechanisms of action are primarily related to their antioxidant properties, but enzymatic inhibition and other pathways may also be relevant. © 2011 Elsevier Ltd. 46 1 378 386 Adisakwattana, S., Charoenlertkul, P., Yibchok-Anun, S., A-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose (2009) Journal of Enzyme Inhibition and Medicinal Chemistry, 24, pp. 65-69 Ahrén, B., Type 2 diabetes, insulin secretion and β-cell mass (2005) Current Molecular Medicine, 5, pp. 275-286 Ames, B.M., Shigena, M.K., Hagen, T.M., Oxidants, antioxidants and the degenerative diseases of aging (1993) Proceedings of the National Academy of Sciences U.S.A., 90, pp. 7915-7922 Araki, E., Oyadomari, S., Mori, M., Endoplasmic reticulum stress and diabetes mellitus (2003) Internal Medicine, 42, pp. 7-14 Ataie-Jafari, A., Hosseini, S., Karimi, F., Pajouhi, M., Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women (2008) A pilot study. Nutrition & Food Science, 38, pp. 355-360 Aura, A.M., Martin-Lopez, P., O'Leary, K.A., Williamson, G., Oksman-Caldentey, K.M., Poutanen, K., Santos-Buelga, C., In vitro metabolism of anthocyanins by human gut microflora (2005) European Journal of Nutrition, 44, pp. 133-142 Awika, J.M., Rooney, L.W., Waniska, R.D., Anthocyanins from black sorghum and their antioxidant properties (2005) Food Chemistry, 90, pp. 293-301 Baron, A.D., Postprandial hyperglycaemia and α-glucosidase inhibitors (1998) Diabetes Research and Clinical Practice, 40, pp. S51-S55 Basu, A., Wilkinson, M., Penugonda, K., Simmons, B., Betts, N.B., Timothy, J., Lyons, T.J., Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: Baseline and post intervention effects (2009) Nutrition Journal, 8, pp. 43-49 Baynes, J.W., Thorpe, S.R., Perspectives in diabetes, role of oxidative stress in diabetic complications. A new perspective on an old paradigm (1999) Diabetes, 48, pp. 1-9 Bitsch, R., Netzel, N., Frank, T., Strass, G., Bitsch, I., Bioavailability and biokinetics of anthocyanins from red grape juice and red wine (2004) Journal of Biomedicine & Biotechnology, 5, pp. 293-298 Bonina, F.P., Leorra, C., Scalia, G., Puglia, C., Trombetta, D., Tringali, G., Roccazzello, A.M., Saija, A., Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract (2002) Diabetes, Nutrition & Metabolism, 15, pp. 14-19 Bouwens, L., Rooman, I., Regulation of pancreatic betacell mass (2005) Physiological Reviews, 85, pp. 1255-1270 Brouillard, R., Iacobucci, G.A., Sweeny, J.G., Chemistry of anthocyanin pigments. 9. UV-visible spectrophotometric determination of the acidity constants of apigeninidin and three related 3-deoxyflavylium salts (1982) Journal of the American Chemical Society, 104, pp. 7585-7590 Bryant, N.J., Govers, R., James, D.E., Regulated transport of the glucose transporter GLUT4 (2002) Nature Reviews. Molecular Cell Biology, 3, pp. 267-277 Bub, A., Watzl, B., Heeb, D., Rechkemmer, G., Briviba, K., Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice (2001) European Journal of Nutrition, 40, pp. 113-120 Cao, G.U., Muccitelli, H.U., Sánchez-Moreno, C., Prior, R.L., Anthocyanins are absorbed in glycated forms in elderly women: A pharmacokinetic study (2001) The American Journal of Clinical Nutrition, 73, pp. 920-926 Cevallos-Casals, B.A., Cisneros-Zevallos, L., Stability of anthocyanin-based aqueous extracts of Andean purple corn and red-fleshed sweet potato compared to synthetic and natural colorants (2004) Food Chemistry, 86, pp. 69-77 Chambers, B.K., Camire, M.H., Can cranberry supplementation benefit adults with type 2 diabetes? (2003) Diabetes Care, 26, pp. 2695-2696 Charron, C.S., Kurilich, A.C., Beverly, A., Clevidence, B.A., Simon, P.W., Harrison, D.J., Britz, S.J., Novotny, J.A., Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix (2009) Journal of Agricultural and Food Chemistry, 57, pp. 1226-1230 Chiasson, J.L., Josse, R.G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial (2002) The Lancet, 359, pp. 2072-2077 Clifford, M.N., Anthocyanins - nature, occurrence and dietary burden (2000) Journal of the Science of Food and Agriculture, 80, pp. 1063-1072 DeFuria, J., Bennett, G., Strissel, K.J., Perfield, J.W., Milbury, P.E., Greenberg, A.S., Obin, M.S., Dietary blueberry attenuates whole-body insulin resistance in high hat-fed mice by reducing adipocyte death and its inflammatory sequelae (2009) The Journal of Nutrition, 139, pp. 1-7 Del Bò, C., Ciappellano, S., Klimis-Zacas, D., Martini, D., Gardana, C., Riso, P., Porrini, M., Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (Vaccinium angustifolium) is affected by diet duration in the Sprague-Dawley rat (2010) Journal of Agricultural and Food Chemistry, 58, pp. 2491-2497 Donath, M.Y., Sheolson, S.E., Type 2 diabetes as an inflammatory disease (2011) Nature Reviews Immunology, 11, pp. 98-107 Donnelly, R., Emslie-Smith, A.M., Gardner, I.D., Morris, A.D., ABC of arterial and venous disease. Vascular complications of diabetes (2000) British Medical Journal, 320, pp. 1062-1066 Dresner, A., Laurent, D., Marcucci, M., Griffin, M.E., Dufour, S., Cline, G.W., Slezak, L.A., Rothman, D.L., Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity (1999) The Journal of Clinical Investigation, 103, pp. 253-259 Ehlenfeldt, M.K., Prior, R.L., Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry (2001) Journal of Agricultural and Food Chemistry, 49, pp. 2222-2227 Evans, J.L., Goldfine, I.D., Maddux, B.A., Grodsky, G.M., Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction? (2003) Diabetes, 52, pp. 1-8 Felgines, C., Talavera, S., Gonthier, M.P., Texier, O., Scalbert, A., Lamaison, J.L., Rémésy, C., Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans (2003) The Journal of Nutrition, 133, pp. 1296-1301 Felgines, C., Talavera, S., Texier, O., Gil-Izquierdo, A., Lamaison, J.L., Rémésy, C., Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans (2005) Journal of Agricultural and Food Chemistry, 53, pp. 7721-7727 Feshani, A.M., Kouhsar, S.M., Mohammadi, S., Vaccinium arctostaphylos, a common herbal medicine in Iran: molecular and biochemical study of its antidiabetic effects on alloxan-diabetic Wistar rats (2011) Journal of Ethnopharmacology, 133, pp. 67-74 Forester, S.C., Waterhouse, A.L., Metabolites are key to understanding health effects of wine polyphenolics (2009) The Journal of Nutrition, 138, pp. 1824S-1831S Forester, S.C., Waterhouse, A.L., Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells (2010) Journal of Agricultural and Food Chemistry, 58, pp. 5320-5327 Furuta, M., Yano, Y., Gabazza, E.C., Araki-Sasaki, R., Tanaka, T., Katsuki, A., Hori, Y., Adachi, Y., Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus (2002) Diabetes Research and Clinical Practice, 56, pp. 159-171 Grace, M.H., David, M., Ribnicky, D.M., Kuhnb, P., Poulev, A., Logendra, S., Yousef, G.G., Lila, M.A., Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton (2009) Phytomedicine, 16, pp. 406-415 Gray, G.M., Lally, B.C., Conklin, K.A., Action of intestinal sucrase-isomaltase and its free monomers on an α-limit dextrin (1979) The Journal of Biological Chemistry, 254, pp. 6038-6043 Guo, H., Ling, W., Liu, C., Hu, Y., Xia, M., Feng, X., Xia, X., Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats (2007) Plant Foods for Human Nutrition, 62, pp. 1-6 He, J., Magnuson, B.A., Giusti, M.M., Analysis of anthocyanins in rat intestinal contents - Impact of anthocyanin chemical structure on fecal excretion (2005) Journal of Agricultural and Food Chemistry, 53, pp. 2859-2866 He, J., Giusti, M.M., Anthocyanins: natural colorants with health-promoting properties (2010) Annual Review of Food Science and Technology, 1, pp. 163-187 Heinonen, I.M., Meyer, A.S., Frankel, E.N., Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation (1998) Journal of Agricultural and Food Chemistry, 46, pp. 4107-4112 Houstis, N., Rosen, E.D., Lander, E.S., Reactive oxygen species have a causal role in multiple forms of insulin resistance (2006) Nature, 440, pp. 944-948 Hunt, J.V., Smith, C.C., Wolff, S.P., Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose (1990) Diabetes, 39, pp. 1420-1424 Ichiyanagi, T., Rahman, M.M., Kashiwada, Y., Ikeshiro, Y., Shida, Y., Hatano, Y., Matsumoto, H., Konishi, T., Absorption and metabolism of delphinidin 3-O-β-d-glucopyranoside in rats (2004) Free Radical Biology & Medicine, 36, pp. 930-937 Iwai, K., Onodera, A., Matsue, H., Inhibitory effects of Viburnum dilatatum Thunb. (Gamazumi) on oxidation and hyperglycemia in rats with streptozotocin-induced diabetes (2004) Journal of Agricultural and Food Chemistry, 52, pp. 1002-1007 Jain, S.K., McVie, R., Duett, J., Herbst, J.J., Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes (1989) Diabetes, 38, pp. 1539-1543 Jayaprakasam, B., Vareed, S.K., Olson, L.K., Nair, M.G., Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits (2005) Journal of Agricultural and Food Chemistry, 53, pp. 28-31 Jayaprakasam, B., Olson, L.K., Schutzki, R.E., Tai, M.H., Nair, M.G., Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas) (2006) Journal of Agricultural and Food Chemistry, 54, pp. 243-248 Jurgoński, A., Juśkiewicz, J., Zduńczyk, Z., Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia (2008) Plant Foods for Human Nutrition, 63, pp. 176-182 Kähkönen, M.P., Heinonen, M., Antioxidant activity of anthocyanins and their aglycons (2003) Journal of Agricultural and Food Chemistry, 51, pp. 628-633 Kalt, W., Blumberg, J.B., McDonald, J.E., Vinqvist-Tymchuk, M.R., Fillmore, S.A.E., Graf, B.A., O'Leary, J.M., Milbury, P.E., Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs (2008) Journal of Agricultural and Food Chemistry, 56, pp. 705-712 Kaneto, H., Fujii, J., Myint, T., Miyazawa, N., Islam, K.N., Kawasaki, K., Suzuki, K., Taniguchi, N., Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction (1996) Biochemical Journal, 320, pp. 855-863 Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Hori, M., Benefical effects of antioxidants in diabetes, possible protection of pancreatic β-cells against glucose toxicity (1999) Diabetes, 48, pp. 2398-2406 Kay, C.D., Holub, B.J., The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects (2002) British Journal of Nutrition, 88, pp. 389-397 Kay, C.D., Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans (2006) Nutrition Research Reviews, 19, pp. 137-146 Kelley, D.S., Rasooly, R., Jacob, R.A., Kader, A.A., Bruce, E., Mackey, B.E., Consumption of bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women (2006) The Journal of Nutrition, 136, pp. 981-986 Keppler, K., Humpf, H.U., Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora (2005) Bioorganic & Medicinal Chemistry, 13, pp. 5195-5205 Kong, J.M., Chia, L.S., Goh, N.K., Chia, T.F., Brouillard, R., Analysis and biological activities of anthocyanins (2003) Phytochemistry, 64, pp. 923-933 Lapidot, T., Harel, S., Akiri, B., Granit, R., Kanner, J., PH-dependent forms of red wine anthocyanins as antioxidants (1999) Journal of Agricultural and Food Chemistry, 47, pp. 67-70 Leite, A.V., Malta, L.G., Riccio, M.F., Eberlin, M.N., Pastore, G.M., Maróstica Júnior, M.R., Antioxidant potential of rat plasma by administration of freeze-dried jaboticaba peel (Myrciaria jaboticaba Vell Berg) (2011) Journal of Agricultural and Food Chemistry, 59, pp. 2277-2283 Manach, C., Scalbert, A., Morand, C., Rémésy, C., Jiménez, L., Polyphenols: Food sources and bioavailability (2004) The American Journal of Clinical Nutrition, 79, pp. 727-747 Martineau, L.C., Couture, A., Spoora, S., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Haddad, P.S., Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait (2006) Phytomedicine, 13, pp. 612-623 Matsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., Matsumoto, K., α-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity (2001) Journal of Agricultural and Food Chemistry, 49, pp. 1948-1951 Matsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., Matsumoto, K., α-Glucosidase inhibitory action of natural acylated anthocyanins. 2. α-glucosidase inhibition by isolated acylated anthocyanins (2001) Journal of Agricultural and Food Chemistry, 49, pp. 1952-1956 Matsui, T., Ebichi, S., Kobayashi, M., Fukui, K., Sugita, K., Terahara, N., Matsumoto, K., Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the α-glucosidase inhibitory action (2002) Journal of Agricultural and Food Chemistry, 50, pp. 7244-7248 Matsuzawa, Y., Adipocytokines and metabolic syndrome (2005) Seminars in Vascular Medicine, 5, pp. 34-39 Matuschek, M.C., Hendriks, W.H., McGhie, T.K., Reynolds, G.W., The jejunum is the main site of absorption for anthocyanins in mice (2006) The Journal of Nutritional Biochemistry, 17, pp. 31-36 Mazza, G., Brouillard, R., Recent developments in stabilization of anthocyanins in food products (1987) Food Chemistry, 25, pp. 207-225 Mazza, G., Kay, C.D., Cottrell, T., Holub, B.J., Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects (2002) Journal of Agricultural and Food Chemistry, 50, pp. 7731-7737 McDougall, G.J., Stewart, D., The inhibitory effects of berry polyphenols on digestive enzymes (2005) BioFactors, 23, pp. 189-195 McGhie, T.K., Ainge, G.D., Barnett, L.E., Cooney, J.M., Jensen, D.J., Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolised by both humans and rats (2003) Journal of Agricultural and Food Chemistry, 51, pp. 4539-4548 McGhie, T.K., Walton, M.C., The bioavailability and absorption of anthocyanins: Towards a better understanding (2007) Molecular Nutrition & Food Research, 51, pp. 702-713 Moyer, R.A., Hummer, K.E., Finn, C.E., Frei, B., Wrolstad, R.E., Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes (2002) Journal of Agricultural and Food Chemistry, 50, pp. 519-525 Nickavar, B., Amin, G., Anthocyanins from Vaccinium arctostaphylos berries (2004) Pharmaceutical Biology, 42, pp. 289-291 Nizamutdinova, I.T., Jin, Y.C., Chung, J., Shin, S.C., Lee, S.J., Seo, H.G., Lee, J.H., Kim, H.J., The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis (2009) Molecular Nutrition & Food Research, 53, pp. 1419-1429 Nöthlings, U., Schulze, M.B., Weikert, C., Boeing, H., Schouw, Y.T., Bamia, C., Benetou, V., Trichopoulo, A., Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population (2008) The Journal of Nutrition, 138, pp. 775-781 Nurmi, T., Mursu, J., Heinonen, M., Nurmi, A., Hiltunen, R., Voutilainen, S., Metabolism of berry anthocyanins to phenolic acids in humans (2009) Journal of Agricultural and Food Chemistry, 57, pp. 2274-2281 Ohnishi, R., Ito, H., Kasajima, N., Kaneda, M., Kariyama, R., Kumon, H., Hatano, T., Yoshida, T., Urinary excretion of anthocyanins in humans after cranberry juice ingestion (2006) Bioscience, Biotechnology, and Biochemistry, 70, pp. 1681-1687 Passamonti, S., Vrhovsek, U., Vanzo, A., Mattivi, F., The stomach as a site for anthocyanins absorption from food (2003) FEBS Letters, 544, pp. 210-213 Philpott, M., Gould, K.S., Lim, C., Ferguson, L.R., In situ and in vitro antioxidant activity of sweet potato anthocyanins (2004) Journal of Agricultural and Food Chemistry, 52, pp. 1511-1513 Pileggi, A., Molano, R.D., Berney, T., Cattan, P., Vizzardelli, C., Oliver, R., Fraker, C., Inverardi, L., Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation (2001) Diabetes, 50, pp. 1983-1991 Prior, R.L., Cao, G., Martin, A., Sofic, E., McEwen, J., O'Brien, C., Lischner, N., Mainland, C.M., Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species (1998) Journal of Agricultural and Food Chemistry, 46, pp. 2686-2693 Prior, R.L., Wu, X., Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities (2006) Free Radical Research, 40, pp. 1014-1028 Prior, R.L., Wu, X., Gu, L., Hager, T., Hager, A., Wilkes, S., Howard, L., Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet (2009) Molecular Nutrition & Food Research, 53, pp. 1406-1418 Prior, R.L., Wilkes, S.E., Rogers, T.R., Khanal, R.C., Wu, X., Howard, L.R., Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet (2010) Journal of Agricultural and Food Chemistry, 58, pp. 3970-3976 Rechner, A.R., Kuhnle, G., Bremner, P., Hubbard, G.P., Moore, K.P., Rice-Evans, C., The metabolic fate of dietary polyphenols in humans (2002) Free Radical Biology & Medicine, 33, pp. 220-235 Roy, M., Sen, S., Chakraborti, A.S., Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: Implication for glycation-induced hemoglobin modification (2008) Life Sciences, 82, pp. 1102-1110 Sartipy, P., Loskutoff, D.J., Monocyte chemoattractant protein 1 in obesity and insulin resistance (2003) Proceedings of the National Academy of Science of the USA, 100, pp. 7265-7270 Sasaki, R., Nishimura, N., Hoshino, H., Isa, Y., Kadowaki, M., Ichi, T., Tanaka, A., Tsuda, T., Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice (2007) Biochemical Pharmacology, 74, pp. 1619-1627 Satué-Gracia, M.T., Heinonen, M., Frankel, E., Anthocyanins as antioxidants on human low-density lipoprotein and lecithin-liposome systems (1997) Journal of Agricultural and Food Chemistry, 45, pp. 3362-3367 Scalbert, A., Williamson, G., Dietary intake and bioavailability of polyphenols (2000) The Journal of Nutrition, 130, pp. 2073S-2085S Seeram, N., Berry fruits: Compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease (2008) Journal of Agricultural and Food Chemistry, 56, pp. 627-629 Seymour, E.M., Singer, A.M.A., Kirakosyan, A., Urcuyo-Llanes, D.E., Kaufman, P.B., Bolling, S.F., Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry (2008) Journal of Medicinal Food, 11, pp. 252-259 Seymour, E.M., Lewis, S.K., Urcuyo-Llanes, D.E., Tanone, I.I., Kirakosyan, A., Kaufman, P.B., Bolling, S.F., Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet (2009) Journal of Medicinal Food, 12, pp. 935-942 Stintzing, F.C., Carle, R., Functional properties of anthocyanins and betalains in plants, food, and in human nutrition (2004) Trends in Food Science & Technology, 15, pp. 19-38 Stumvoll, M., Goldstein, B.J., van Haeften, T.W., Type 2 diabetes: Principles of pathogenesis and therapy (2005) The Lancet, 365, pp. 1333-1346 Sugimoto, E., Igarachi, K., Kubo, K., Molineux, J., Kubomura, K., Protective effects of boysenberry anthocyanins on oxidative stress in diabetic rats (2003) Food Science and Technology Research, 9, pp. 345-349 Takikawa, M., Inoue, S., Horio, F., Tsuda, T., Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice (2010) The Journal of Nutrition, 140, pp. 527-533 Talavéra, S., Felgines, C., Texier, O., Besson, C., Lamaison, J.L., Rémésy, C., Anthocyanins are efficiently absorbed from the stomach in anesthetized rats (2003) The Journal of Nutrition, 133, pp. 4178-4182 Talavéra, S., Felgines, C., Texier, O., Besson, C., Manach, C., Lamaison, J.L., Rémésy, C., Anthocyanins are efficiently absorbed from the small intestine in rats (2004) The Journal of Nutrition, 134, pp. 2275-2279 Tian, Q., Giusti, M.M., Stoner, G.D., Schwartz, S.J., Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites (2006) Journal of Agricultural and Food Chemistry, 54, pp. 1467-1472 Tiedge, M., Lortz, S., Drinkgern, J., Lenzen, S., Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells (1997) Diabetes, 46, pp. 1733-1742 Tourrel, C., Bailbe, D., Lacorne, M., Meile, M.J., Kergoart, M., Portha, B., Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the β-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4 (2002) Diabetes, 51, pp. 1443-1452 Traustadóttir, T., Davies, S.S., Stock, A.A., Su, Y., Heward, C.B., Roberts, L.J., Harman, S.M., Tart cherry juice decreases oxidative stress in healthy older men and women (2009) The Journal of Nutrition, 139, pp. 1896-1900 Tsuda, T., Shiga, K., Ohshima, K., Kawakishi, S., Osawa, T., Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L (1996) Biochemical Pharmacology, 52, pp. 1033-1039 Tsuda, A., Horio, F., Osawa, T., Absorption and metabolism of cyanidin 3-O-l-d-glucoside in rats (1999) FEBS Letters, 449, pp. 179-182 Tsuda, T., Horio, F., Kitoh, J., Osawa, T., Protective effects of dietary cyanidin 3-O-beta-d-glucoside on liver ischemia-reperfusion injury in rats (1999) Archives of Biochemistry and Biophysics, 368, pp. 361-366 Tsuda, T., Horio, F., Uchida, K., Aoki, H., Osawa, T., Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice (2003) The Journal of Nutrition, 133, pp. 2125-2130 Tsuda, T., Ueno, Y., Kojo, H., Yoshikawa, T., Osawa, T., Gene expression profile of isolated rat adipocytes treated with anthocyanins (2005) Biochimica et Biophysica Acta, 1733, pp. 137-147 Vitaglione, P., Donnarumma, G., Napolitano, A., Galvano, F., Gallo, A., Scalfi, L., Fogliano, V., Protocatechuic acid is the major human metabolite of cyanidin-glucosides (2007) The Journal of Nutrition, 137, pp. 2043-2048 Walle, T., Absorption and metabolism of flavonoids (2004) Free Radical Biology & Medicine, 36, pp. 829-837 Wang, D., Wei, X., Yan, X., Jin, T., Ling, A., Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice (2010) Journal of Agricultural and Food Chemistry, 58, pp. 12722-12728 Weisel, T., Baum, M., Eisenbrand, G., Dietrich, H., Will, F., Stockis, J.P., Kulling, S., Christine Janzowski, C., An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands (2006) Biotechnology Journal, 1, pp. 388-397 Wild, S., Roglic, G., Green, A., Sicree, R., King, H., Global prevalence of diabetes estimates for the year 2000 and projections for 2030 (2004) Diabetes Care, 27, pp. 1047-1053 Woodward, G.M., Needs, P.W., Kay, C.D., Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation (2010) Molecular Nutrition & Food Research, 54, pp. 1-9 Wu, X., Cao, G., Prior, R.L., Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry (2002) The Journal of Nutrition, 132, pp. 1865-1871 Wu, X., Pittman, H.E., Mckay, S., Prior, R.L., Aglycones and sugar moieties alter anthocyanin absorption and metabolism after berry consumption in weanling pigs (2005) The Journal of Nutrition, 135, pp. 2417-2424 Xu, J.W., Ikeda, K., Yamori, Y., Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment (2004) Hypertension, 44, pp. 217-222 Yang, Q., Graham, T.E., Mody, N., Preitner, F., Peroni, O.D., Zabolotny, J.M., Kotani, K., Kahn, B.B., Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes (2005) Nature, 436, pp. 356-362 Yang, M.I., Koo, S.O., Song, W.K., Chun, O., Food matrix affecting anthocyanin bioavailability: Review (2011) Current Medicinal Chemistry, 18, pp. 291-300 Yi, W., Akoh, C.C., Foscher, J., Krewer, G., Absorption of anthocyanins from blueberry extracts by Caco-2 human intestinal cell monolayers (2006) Journal of Agricultural and Food Chemistry, 54, pp. 5651-5658 Zhang, B., Kang, M., Xie, Q., Xu, B., Sun, C., Chen, K., Wu, Y., Anthocyanins from Chinese bayberry extract protect β cells from oxidative stress-mediated injury via HO-1 upregulation (2011) Journal of Agricultural and Food Chemistry, 59, pp. 537-545