Artículos de revistas
Maternal High-fat Feeding Through Pregnancy And Lactation Predisposes Mouse Offspring To Molecular Insulin Resistance And Fatty Liver
Registro en:
Journal Of Nutritional Biochemistry. , v. 23, n. 4, p. 341 - 348, 2012.
9552863
10.1016/j.jnutbio.2010.12.011
2-s2.0-84858289329
Autor
Ashino N.G.
Saito K.N.
Souza F.D.
Nakutz F.S.
Roman E.A.
Velloso L.A.
Torsoni A.S.
Torsoni M.A.
Institución
Resumen
The exposure to an increased supply of nutrients before birth may contribute to offspring obesity. Offspring from obese dams that chronically consume a high-fat diet present clinical features of metabolic syndrome, liver lipid accumulation and activation of c-Jun N-terminal kinases (JNK) consistent with the development of nonalcoholic fatty liver disease (NAFLD). However, in spite of the importance of the resistance to insulin for the development of NAFLD, the molecular alterations in the liver of adult offspring of obese dams are yet to be investigated. In this study, we tested the hypothesis that the consumption of excessive saturated fats during pregnancy and lactation contributes to adult hepatic metabolic dysfunction in offspring. Adult male offspring of dams fed a high-fat diet (HN) during pregnancy and lactation exhibited increased fat depot weight; increased serum insulin, tumor necrosis factor α and interleukin 1β; and reduced serum triglycerides. Liver showed increased JNK and I kappa B kinase phosphorylation and PEPCK expression in the adult. In addition, liver triglyceride content in the offspring 1 week after weaning and in the adult was increased. Moreover, basal ACC phosphorylation and insulin signaling were reduced in the liver from the HN group as compared to offspring of dams fed a standard laboratory chow (NN). Hormone-sensitive lipase phosphorylation (Ser565) was reduced in epididymal adipose tissue from the HN group as compared to the NN group. It is interesting that all changes observed were independent of postweaning diet in 14-week-old offspring. Therefore, these data further reinforce the importance of maternal nutrition to adult offspring health. © 2012 Elsevier Inc. 23 4 341 348 Silverman, B.L., Rizzo, T.A., Cho, N.H., Metzger, B.E., Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center (1998) Diabetes Care, 21 (SUPPL. 2), pp. B142-B149 Plagemann, A., Harder, T., Rake, A., Waas, T., Melchior, K., Ziska, T., Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats (1999) J Neuroendocrinol, 11, pp. 541-546 Srinivasan, M., Katewa, S.D., Palaniyappan, A., Pandya, J.D., Patel, M.S., Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood (2006) Am J Physiol Endocrinol Metab, 291, pp. E792-E799 Armitage, J.A., Taylor, P.D., Poston, L., Experimental models of developmental programming: consequences of exposure to an energy rich diet during development (2005) J Physiol, 565, pp. 3-8 Armitage, J.A., Khan, I.Y., Taylor, P.D., Nathanielsz, P.W., Poston, L., Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? (2004) J Physiol, 561, pp. 355-377 McCurdy, C.E., Bishop, J.M., Williams, S.M., Grayson, B.E., Smith, M.S., Friedman, J.E., Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates (2009) J Clin Invest, 119, pp. 323-335 Chechi, K., Cheema, S.K., Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice (2006) Exp Clin Cardiol, 11, pp. 129-135 Albuquerque, K.T., Sardinha, F.L., Telles, M.M., Watanabe, R.L., Nascimento, C.M., Tavares do Carmo, M.G., Intake of trans fatty acid-rich hydrogenated fat during pregnancy and lactation inhibits the hypophagic effect of central insulin in the adult offspring (2006) Nutrition, 22, pp. 820-829 Chang, G.Q., Gaysinskaya, V., Karatayev, O., Leibowitz, S.F., Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity (2008) J Neurosci, 28, pp. 12107-12119 Marchesini, G., Bugianesi, E., Forlani, G., Cerrelli, F., Lenzi, M., Manini, R., Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome (2003) Hepatology, 37, pp. 917-923 Challier, J.C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P.M., Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta (2008) Placenta, 29, pp. 274-281 Hotamisligil, G.S., Inflammatory pathways and insulin action (2003) Int J Obes Relat Metab Disord, 27 (SUPPL. 3), pp. S53-S55 Hotamisligil, G.S., Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes (2005) Diabetes, 54 (SUPPL. 2), pp. S73-S78 De Souza, C.T., Araujo, E.P., Bordin, S., Ashimine, R., Zollner, R.L., Boschero, A.C., Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus (2005) Endocrinology, 146, pp. 4192-4199 Semple, R.K., Sleigh, A., Murgatroyd, P.R., Adams, C.A., Bluck, L., Jackson, S., Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis (2009) J Clin Invest, 119, pp. 315-322 Newberry, E.P., Xie, Y., Kennedy, S., Han, X., Buhman, K.K., Luo, J., Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene (2003) J Biol Chem, 278, pp. 51664-51672 Carr, T.P., Andresen, C.J., Rudel, L.L., Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts (1993) Clin Biochem, 26, pp. 39-42 Elahi, M.M., Cagampang, F.R., Mukhtar, D., Anthony, F.W., Ohri, S.K., Hanson, M.A., Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice (2009) Br J Nutr, 102, pp. 514-519 Guo, F., Jen, K.L., High-fat feeding during pregnancy and lactation affects offspring metabolism in rats (1995) Physiol Behav, 57, pp. 681-686 Taylor, P.D., McConnell, J., Khan, I.Y., Holemans, K., Lawrence, K.M., Asare-Anane, H., Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy (2005) Am J Physiol Regul Integr Comp Physiol, 288, pp. R134-R139 Seeber, R.M., Smith, J.T., Waddell, B.J., Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat (2002) Biol Reprod, 66, pp. 1762-1767 Howie, G.J., Sloboda, D.M., Kamal, T., Vickers, M.H., Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet (2009) J Physiol, 587, pp. 905-915 Kirwan, J.P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.C., Huston-Presley, L., Friedman, J.E., TNF-alpha is a predictor of insulin resistance in human pregnancy (2002) Diabetes, 51, pp. 2207-2213 Gupta, A., Srinivasan, M., Thamadilok, S., Patel, M.S., Hypothalamic alterations in fetuses of high fat diet-fed obese female rats (2009) J Endocrinol, 200, pp. 293-300 White, C.L., Purpera, M.N., Morrison, C.D., Maternal obesity is necessary for programming effect of high-fat diet on offspring (2009) Am J Physiol Regul Integr Comp Physiol, 296, pp. R1464-R1472 Bugianesi, E., McCullough, A.J., Marchesini, G., Insulin resistance: a metabolic pathway to chronic liver disease (2005) Hepatology, 42, pp. 987-1000 Fabbrini, E., Sullivan, S., Klein, S., Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications (2010) Hepatology, 51, pp. 679-689 Donnelly, K.L., Smith, C.I., Schwarzenberg, S.J., Jessurun, J., Boldt, M.D., Parks, E.J., Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease (2005) J Clin Invest, 115, pp. 1343-1351 Munday, M.R., Regulation of mammalian acetyl-CoA carboxylase (2002) Biochem Soc Trans, 30, pp. 1059-1064 Caluwaerts, S., Lambin, S., van Bree, R., Peeters, H., Vergote, I., Verhaeghe, J., Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring (2007) Metabolism, 56, pp. 1431-1438 Koukkou, E., Ghosh, P., Lowy, C., Poston, L., Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction (1998) Circulation, 98, pp. 2899-2904 Cintra, D.E., Pauli, J.R., Araujo, E.P., Moraes, J.C., de Souza, C.T., Milanski, M., Interleukin-10 is a protective factor against diet-induced insulin resistance in liver (2008) J Hepatol, 48, pp. 628-637 Lee, Y.H., Giraud, J., Davis, R.J., White, M.F., C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade (2003) J Biol Chem, 278, pp. 2896-2902 Cai, D., Yuan, M., Frantz, D.F., Melendez, P.A., Hansen, L., Lee, J., Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB (2005) Nat Med, 11, pp. 183-190 Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., IKK-beta links inflammation to obesity-induced insulin resistance (2005) Nat Med, 11, pp. 191-198 Zhang, C.M., Gu, Y., Qing, D.N., Zhu, J.G., Zhu, C., Zhang, M., Tissue-specific distribution of uncoupling proteins in normal rats and rats with high-fat-diet-induced obesity (2009) Mol Biol Rep Samuelsson, A.M., Matthews, P.A., Argenton, M., Christie, M.R., McConnell, J.M., Jansen, E.H., Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming (2008) Hypertension, 51, pp. 383-392 Armitage, J.A., Poston, L., Taylor, P.D., Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity (2008) Front Horm Res, 36, pp. 73-84