| dc.creator | Lemos T.A. | |
| dc.creator | Kobarg J. | |
| dc.date | 2006 | |
| dc.date | 2015-06-30T18:14:53Z | |
| dc.date | 2015-11-26T14:28:13Z | |
| dc.date | 2015-06-30T18:14:53Z | |
| dc.date | 2015-11-26T14:28:13Z | |
| dc.date.accessioned | 2018-03-28T21:31:23Z | |
| dc.date.available | 2018-03-28T21:31:23Z | |
| dc.identifier | | |
| dc.identifier | Cell Biochemistry And Biophysics. , v. 44, n. 3, p. 463 - 474, 2006. | |
| dc.identifier | 10859195 | |
| dc.identifier | 10.1385/CBB:44:3:463 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-31744447890&partnerID=40&md5=9240e28b8aa567c7beb350e09fd7759d | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/103673 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/103673 | |
| dc.identifier | 2-s2.0-31744447890 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1246535 | |
| dc.description | The human protein CGI-55 has been described as a chromo-helicase-DNA- binding domain protein (CHD)-S interacting protein and was also found to interact with the 3′-region of the plasminogen activator inhibitor (PAI)-1 mRNA. Here, we used CGI-55 as a "bait" in a yeast two-hybrid screen and identified eight interacting proteins: Daxx, Topoisomerase I binding RS (Topors), HPC2, UBA2, TDG, and protein inhibitor of activated STAT (signal transducer and activator of transcription) (PIAS)-1, -3, and -y These proteins are either structurally or functionally associated with promyelocytic leukemia nuclear bodies (PML-NBs), protein sumoylation, or the regulation of transcription. The interactions of CGI-55 with Daxx, Topors, PIASy and UBA2 were confirmed by in vivo co-localization experiments in HeLa cells, by using green (GFP) and red fluorescence fusion proteins. A mapping study of the CGI-55 binding site for these proteins revealed three distinct patterns of interaction. The fact that CGI-55-GFP has been localized in cytoplasm and nucleus in a dotted manner, and its interaction with proteins associated with PML-NBs, suggested that CGI-55 might be associated with nuclear bodies. Although Daxx and Topors co-localized with promyelocytic leukemia protein (PML), CGI-55 itself as well as PIASy and UBA2 showed only little co-localization with PML. However, we observed that CGI-55 localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies. © Copyright 2006 by Humana Press Inc. All rights of any nature whatsoever reserved. | |
| dc.description | 44 | |
| dc.description | 3 | |
| dc.description | 463 | |
| dc.description | 474 | |
| dc.description | Kobarg, J., Schnittger, S., Fonatsch, C., Characterization, mapping and partial cDNA sequence of the 57-kDa intracellular Ki-1 antigen (1997) Exp. Clin. Immunogenet., 14, pp. 273-280 | |
| dc.description | Lemos, T.A., Passos, D.O., Nery, F.C., Kobarg, J., Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3 (2003) FEBS Lett., 533, pp. 14-20 | |
| dc.description | Heaton, J.H., Dlakic, W.M., Dlakic, M., Gelehrter, T.D., Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA (2001) J. Biol. Chem., 276, pp. 3341-3347 | |
| dc.description | Huang, L., Grammatikakis, N., Yoneda, M., Banerjee, S.D., Toole, B.P., Molecular characterization of a novel intracellular hyaluronan-binding protein (2000) J. Biol. Chem., 275, pp. 29,829-29,839 | |
| dc.description | Nery, F.C., Passos, D.O., Garcia, V.S., Kobarg, J., Ki-1/57 interacts with RACK1 and is a substrate for PMA activated PKC (2004) J. Biol. Chem., 279, pp. 11,444-11,455 | |
| dc.description | Ozaki, T., Watanabe, K.-I., Nakagawa, T., Miyazaki, K., Takahashi, M., Nakagawara, A., Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB (2003) Oncogene, 22, pp. 3231-3242 | |
| dc.description | Matera, A.G., Nuclear bodies: Multifaceted subdomains of the interchromatin space (1999) Trends Cell Biol., 9, pp. 302-309 | |
| dc.description | Andrade, L.E.C., Tan, E.M., Chan, E.K.L., Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation (1993) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 1947-1951 | |
| dc.description | Ogg, S.C., Lamond, A.I., Cajal bodies and coilin-moving towards function (2002) J. Cell Biol., 14, pp. 17-21 | |
| dc.description | Zhong, S., Salomoni, P., Pandolfi, P., The transcriptional role of PML and the nuclear body (2000) Nat. Cell Biol., 2, pp. E85-E90 | |
| dc.description | Rasheed, Z.A., Saleem, A., Ravee, Y., Pandolfi, P.P., Rubin, E.H., The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies (2002) Exp. Cell Res., 277, pp. 152-160 | |
| dc.description | Salomoni, P., Pandolfi, P.P., The role of PML in tumor suppression (2002) Cell, 108, pp. 165-170 | |
| dc.description | Everett, R.D., Lomonte, P., Sternsdorf, T., Van Driel, R., Orr, A., Cell cycle regulation of PML modification and ND10 composition (1999) J. Cell Sci., 112, pp. 4581-4588 | |
| dc.description | Zhong, S., Müller, S., Ronchetti, S., Freemont, P.S., Dejean, A., Pandolfi, P.P., Role of SUMO-1-modified PML in nuclear body formation (2000) Blood, 95, pp. 2748-2752 | |
| dc.description | Borden, K.L., Pondering the promyelocytic leukemia protein (PML) puzzle: Possible functions from PML nuclear bodies (2002) Mol. Cell. Biol., 22, pp. 5259-5269 | |
| dc.description | Sterndorf, T., Jensen, K., Will, H., Evidence for covalent modification of the nuclear dot-associated proteins PML and SP100 by PIC1/SUMO1 (1997) J. Cell Biol., 139, pp. 1621-1634 | |
| dc.description | Ishov, A.M., Sotnikov, A.G., Negorev, D., PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1 (1999) J. Cell Biol., 147, pp. 221-234 | |
| dc.description | Fields, S., Song, O., A novel genetic system to detect protein-protein interactions (1989) Nature, 340, pp. 245-246 | |
| dc.description | Vojtek, A.B., Hollenberg, S.M., Ras-Raf interaction: Two-hybrid analysis (1995) Methods Enzymol., 255, pp. 331-342 | |
| dc.description | Moraes, K.C., Quaresma, A.J., Maehnss, K., Kobarg, J., Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D) (2003) Biol. Chem., 384, pp. 35-37 | |
| dc.description | Schmidt, D., Müller, S., Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity (2002) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 2872-2877 | |
| dc.description | Kotaja, N., Karvonen, U., Janne, O.A., Palvimo, J.J., PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases (2002) Mol. Cell Biol., 22, pp. 5222-5234 | |
| dc.description | Müller, S., Matunis, M.J., Dejean, A., Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus (1998) EMBO J., 17, pp. 61-70 | |
| dc.description | Valdez, B.C., Henning, D., Perlaky, L., Busch, R.K., Busch, H., Cloning and characterization of Gu/RH-II binding protein (1997) Biochem. Biophys. Res. Commun., 234, pp. 335-340 | |
| dc.description | Miyauchi, Y., Yogosawa, S., Honda, R., Nishida, T., Yasuda, H., Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes (2002) J. Biol. Chem., 277, pp. 50,131-50,136 | |
| dc.description | Haluska Jr., P., Saleem, A., Rasheed, Z., Interaction between human topoisomerase I and a novel RING-finger/arginine-serine protein (1999) Nucleic Acids Res., 27, pp. 2538-2544 | |
| dc.description | Zhou, R., Wen, H., Ao, S.Z., Identification of a novel gene encoding a p53-associated protein (1999) Gene, 235, pp. 93-101 | |
| dc.description | Rechsteiner, M., Rogers, S.W., PEST sequences and regulation by proteolysis (1996) Trends Biochem. Sci., 21, pp. 267-271 | |
| dc.description | Torii, S., Egan, D.A., Evans, R.A., Reed, J.C., Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs) (1999) EMBO J., 18, pp. 6037-6049 | |
| dc.description | Li, R., Pei, H., Watson, D.K., Papas, T.S., EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes (2000) Oncogene, 19, pp. 745-753 | |
| dc.description | Ko, Y.G., Kang, Y.S., Park, H., Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm (2001) J. Biol. Chem., 276, pp. 39,103-39,106 | |
| dc.description | Lin, D.Y., Lai, M.Z., Ann, D.K., Shih, H.M., Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by Sequestering Daxx to the PML oncogenic domains (PODs) to enhance its trans-activation potential (2003) J. Biol. Chem., 278, pp. 15,958-15,965 | |
| dc.description | Shih, H.P., Hales, K.G., Pringle, J.R., Peifer, M., Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila (2002) J. Cell Sci., 115, pp. 1259-1271 | |
| dc.description | Chu, D., Kakazu, N., Gorrin-Rivas, M.J., Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence (2001) J. Biol. Chem., 276, pp. 14,004-14,013 | |
| dc.description | Yang, X., Khosravi-Far, R., Chang, H.Y., Baltimore, D., Daxx, a novel Fas-binding protein that activates JNK and apoptosis (1997) Cell, 89, pp. 1067-1076 | |
| dc.description | Emelyanov, A.V., Kovac, C.R., Sepulveda, M.A., Birshtein, B.K., The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells (2002) J. Biol. Chem., 277, pp. 11,156-11,164 | |
| dc.description | Pluta, A.F., Earnshaw, W.C., Goldberg, I.G., Interphase-specific association of intrinsic centromer protein CENP-C with Daxx, a death domain-binding protein implicated in Fas-mediated cell death (1998) J. Cell. Sci., 111, pp. 2029-2041 | |
| dc.description | Satijn, D.P., Olson, D.J., Van Der Vlag, J., Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis (1997) Mol. Cell Biol., 17, pp. 6076-6086 | |
| dc.description | Liu, B., Liao, J., Rao, X., Inhibition of Stat1-mediated gene activation by PIAS1 (1998) Proc. Nat. Acad. Sci. U.S.A., 95, pp. 10,626-10,631 | |
| dc.description | Kahyo, T., Nishida, T., Yasuda, H., Involvement of PIAS1 in the sumoylation of tumor suppressor p53 (2001) Mol. Cell, 8, pp. 713-718 | |
| dc.description | Jackson, P.K., A new RING for SUMO: Wrestling transcriptional responses into nuclear bodieswith PIAS family E3 SUMO ligases (2001) Genes Dev., 15, pp. 3053-3058 | |
| dc.description | Desterro, J.M., Rodríguez, M.S., Kemp, G.D., Hay, R.T., Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1 (1999) J. Biol. Chem., 274, pp. 10,618-10,624 | |
| dc.description | Gong, L., Li, B., Millas, S., Yeh, E.T., Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex (1999) FEBS Lett., 448, pp. 185-189 | |
| dc.description | Okuma, T., Honda, R., Ichikawa, G., Tsumagari, N., Yasuda, H., In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2 (1999) Biochem. Biophys. Res. Commun., 254, pp. 693-698 | |
| dc.description | Rodriguez, M.S., Desterro, J.M., Lían, S., Midgley, C.A., Lane, D.P., Hay, R.T., SUMO-1 modification activates the transcriptional response of p53 (1999) EMBO J., 18, pp. 6455-6461 | |
| dc.description | Neddermann, P., Gallinari, P., Lettieri, T., Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase (1996) J. Biol. Chem., 271, pp. 12,767-12,774 | |
| dc.description | Lindahl, T., DNA repair enzymes (1982) Annu. Rev. Biochem., 51, pp. 61-87 | |
| dc.description | Hardeland, U., Steinacher, R., Jiricny, J., Schär, P., Modification of the human tymine-DNA-glycosylase by ubiquitin-like proteins facilitates enzymatic turnover (2002) EMBO J., 21, pp. 1456-1464 | |
| dc.description | Takahashi, H., Hatakeyama, S., Saitoh, H., Nakayama, K.I., Noncovalent SUMO-1 binding of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein (PML) (2005) J. Biol. Chem., 280, pp. 5611-5621 | |
| dc.description | Boddy, M.N., Howe, K., Etkin, L.D., Solomon, E., Freemont, P.S., PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia (1996) Oncogene, 13, pp. 971-982 | |
| dc.description | Long, J., Matsura, I., He, D., Wang, G., Shuai, K., Liu, F., Repression of SMAD transcriptional activity by PIASy, an inhibitor of activated STAT (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 9791-9796 | |
| dc.language | en | |
| dc.publisher | | |
| dc.relation | Cell Biochemistry and Biophysics | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Cgi-55 Interacts With Nuclear Proteins And Co-localizes To P80-coilin Positive-coiled Bodies In The Nucleus | |
| dc.type | Actas de congresos | |
