Artículos de revistas
Fasn Expression, Angiogenesis And Lymphangiogenesis In Central And Peripheral Giant Cell Lesions
Registro en:
Journal Of Applied Oral Science. Faculdade De Odontologia De Bauru, v. 22, n. 2, p. 131 - 137, 2014.
16787757
10.1590/1678-775720130509
2-s2.0-84896472838
Autor
Falci S.G.M.
Mesquita A.T.M.
de Andrade B.A.B.
de Miranda J.L.
Leon J.E.
de Almeida O.P.
dos Santos C.R.R.
Institución
Resumen
Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was significantly higher than MVD-CD105, followed by MVD-D2-40. Moreover, a significantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were significantly higher in PGCL. Positive correlation between MVA-CD105 with FASN-positive mononuclear cells in both lesions was observed. 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