BACKGROUND. To study esophageal motility before and after the endoscopic variceal ligation in cirrhotic patients. METHODS. Twenty-four patients with chronic liver disease assisted at the "Gastrocentro - UNICAMP" in the program of endoscopic variceal ligation were studied (mean age of 49.5 years, 19 males and 5 females). The inclusion criteria were chronic liver disease and esophageal varices with high-risk bleeding. Initially upper digestive endoscopy and esophageal manometry were performed in all cases. Next, the sessions of variceal ligation were initiated (average 3.4±2.1) in the outpatient clinic, with an interval of 2 to 4 weeks. The esophageal manometry was repeated 4 weeks after variceal eradication and amplitude, duration, propagation speed of the contractile waves and peristalsis were studied. RESULTS. Analysis of the lower sphincter pressure did not show differences before and after variceal ligation. In 10 cases (41.6%) dysmotility was recorded, and the amplitude of the contractile waves rose from 70.7 mmHg (52.3 and 108.4) before variceal ligation to 89.7 mmHg (69.9 and 122.8) after the procedure (p = 0.004 - p <0.05), and the duration increased from 3.55 seg. ± 0.58 to 3.90 seg. ± 0.72 (p=0.02 - p <0.05). The wave propagation speed did not differ from the values before the exam of 3.43 ± 0.97 cm/seg, to those after of. 61 ± 0.99 cm/sec (p=0.15 - p>0.05). CONCLUSION. The final analysis shows alterations of esophageal motility characterized by increase in the amplitude and duration of the contractile waves.5229396Collaguazu, P.M.C., Andreollo, N.A., Lopes, L.R., Santos, J.O.M., Yamanaka, A., Magalhães, A.F.N., Associação entre lesões de mucosa gastroduodenal e varizes como causa de hemorragia digestiva alta. Estudo retrospectivo em Hospital Universitário (1993) Arq Gastroenterol, 30, pp. 88-93Andreollo, N.A., Miquelino, M., Lopes, L.R., Santos, J.O.M., Carvalho Jr., A.A., Montes, C.G., Tratamento endoscópico das varizes esofágicas: Ainda há lugar para a escleroterapia? (2002) GED, 21, pp. 59-63Rubenstein, J.H., Eisen, G.M., Inadomi, J.M., A cost-utility analysis of secondary prophylaxis for variceal hemorrhage (2004) Am J Gastroenterol, 99, pp. 1274-1288Hedberg, S.E., Fowler, D.L., Ryan, R.L.R., Injection scleroterapy of esophageal varices using ethanolamine oleato (1982) Am J Surg, 143, pp. 426-431Larson, G.M., Vandertoll, D.J., Netsher, D.T., Polk, H.C., Esophageal motility effects of injection sclerotherapy (1982) Surgery, 96, pp. 703-709Andreollo, N.A., Brandalise, N.A., Leonardi, L.S., A motilidade esofágica após escleroterapia de varizes (1986) GED, 5, pp. 17-21Berner, J.S., Gaing, A.A., Sharma, R., Almenoff, P.L., Muhlfeelder, T., Korsten, M.A., Sequelae after esophageal variceal ligation and sclerotherapy: A prospective randomized study (1994) Am J Gastrenterol, 89, pp. 852-858Viazis, N., Armonis, A., Vlachogiannakos, G.R., Stefanidis, G., Papadimitriou, N., Manolakopoulos, S., Effects of endoscopic variceal treatment on esophageal function: A prospective, randomized study (2002) Eur J Gastroenterol Hepatol, 12, pp. 263-351Steigmann, G.V., Sun, J.H., Hammond, W.S., Results of experimental endoscopic variceal varix ligation (1988) Am Surg, 54, pp. 105-108Chen, S., Lo, G., Lai, K., Jeng, J., Shen, M., Huang, R., Endoscopic variceal ligation and sclerotherapy (1999) J Gastroenterol Hepatol, 14, pp. 231-235Goff, J.S., Reveille, M., Stiegmann, G.V., Three years experience with endoscopic variceal ligation for treatment of bleeding varices (1992) Endoscopy, 24, pp. 401-404Greg, V.S., Goff, J.S., Michaletz-Onody, P.A., Korula, J., Lieberman, D., Saeed, Z.A., Endoscopic sclerotherapy as compared with endoscopic ligation for beending esophageal varices (1992) N Engl J Med, 236, pp. 1527-1532Goff, J.S., Revelle, R.M., Stiegmann, G.V., Endoscopic sclerotherapy versus endoscopic variceal ligation: Esophageal symptoms, complications and motility (1988) Am J Gastroenterol, 83, p. 1240Zargar, S.A., Javid, G., Khan, B.A., Shah, O.J., Yattoo, G.N., Shah, A.H., Endoscopic ligation vs. sclerotherapy in adults with extrahepatic portal venous obstruction: A prospective randomized study (2005) Gastrointest Endosc, 61, pp. 58-66Lopes, C.V., Pereira-Lima, J.C., Pereira-Lima, L.F., Hornos, A.P., Marques, D.L., Cassal, A.P., The efficacy of endoscopic ligation for the prevention of variceal rebleeding in cirrhotic patients according to the hepatocellular function (2004) Hepatogastroenterology, 51, pp. 195-200Kim, C.H., Song, J.H., Kim, H.E., Suck, C.C., Lyou, H.L., Kim, T.H., Effects of endoscopic variceal ligation in lower esophageal motor function: A prospective study (1995) Korean J Int Med, 10, pp. 120-124Passaretti, S., Mazzotti, G., De Franchis, R., Cipolla, M., Testoni, P.A., Tittobello, A., Esophageal motility in cirrhotics with and without esophageal varices (1989) Scand J Gastroenterol, 24, pp. 334-338Avgerinos, A., Viazis, N., Armonis, A., Vlachogiannakos, J., Rekoumis, G., Stefanidis, G., Early increase of lower oesophageal sphincter pressure after band ligation of oesophageal varices in cirrhotics: An intriguing phenomenon (2002) Eur J Gastroenterol Hepatol, 14, pp. 1319-1323Fass, R., Landau, O., Kovasc, T.O.G., Ippoliti, A.D., Esophageal motility abnormalities in cirrhotic patients before and after endoscopic variceal treatment (1997) Am J Gastrentorol, 6, pp. 941-946