Artículos de revistas
Comparative Study Of β-carotene And Microencapsulated β-carotene: Evaluation Of Their Genotoxic And Antigenotoxic Effects
Registro en:
Food And Chemical Toxicology. , v. 50, n. 5, p. 1418 - 1424, 2012.
2786915
10.1016/j.fct.2012.02.030
2-s2.0-84858172449
Autor
Aissa A.F.
Bianchi M.L.P.
Ribeiro J.C.
Hernandes L.C.
de Faria A.F.
Mercadante A.Z.
Antunes L.M.G.
Institución
Resumen
β-Carotene (BC) is one of the natural pigments that is most commonly added to food; however, the utilization of BC is limited due to its instability. Microencapsulation techniques are commonly used because they can protect the microencapsulated material from oxidization. Nevertheless, the properties of the encapsulated compounds must be studied. We compared the antigenotoxic potential of pure and microencapsulated β-carotene (mBC) in Wistar rats. Two doses of BC or mBC (2.5 or 5.0. mg/kg) were administered by gavage over a period of 14. days. The final gavage was followed by an injection of doxorubicin (DXR). After 24. h the animals were euthanized. The micronucleus test results showed that when both mBC and DXR were given, only the higher dose was antigenotoxic. The results of the comet assay show that when given in association with DXR, mBC had protective effects in the liver. 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