Koebner phenomenon is defined as a nonspecific skin stimulus eliciting a disease skin reaction. The nature of the skin trauma varies greatly and includes areas of thermal injury, excoriations, surgical incisions, and scars. We report a patient with recent onset of systemic lupus erythematosus who developed Herpes zoster on immunosuppressant medication. Two weeks after resolution of the vesicles, the patient presented with new ulcerative reddish lesions over the herpes zoster scare and worsening of her malar rash without evidence of worsening of any other organ. Koebner phenomenon was suspected. We review the literature on Koebner phenomenon in SLE. © 2011 Springer-Verlag.32514031405Koebner, H., Zur Aetiologie der Psoriasis (1876) Vierteljahrsschr Dermatol, 8, pp. 539-561Ueki, H., Koebner phenomenon in lupus erythematosus with special consideration of clinical findings (2005) Autoimmun Rev, 4, pp. 219-223Kuner, N., Hartschuh, W., Khan-Durani, B., Heinlich Koebner und der isomorphe Reizeffekte (2003) Geschichte und U Berblick. Hautarzt, 54, pp. 274-278Miller, R.A., The Koebner phenomenon (1982) Int J Dermatol, 21, pp. 192-197Boyd, A.S., Neldner, K.H., The isomorphic response of Koebner (1990) Int J Dermatol, 29, pp. 401-410Desruelles, F., Castanet, J., Botcazou, V., Lacour, J.P., Ortonne, J.P., Koebner phenomenon and multiple morphea (1998) Ann Der-matol Venereol, 125, p. 604King-Smith, D., External irritation as a factor in the causation of le discoides (1926) Arch Dermatol, 14, pp. 547-549Lodin, H., DLE and trauma (1963) Acta Derm-Venereol, 43, pp. 142-148Gupta, S., Many faces of Koebner phenomenon in psoriasis (2002) Indian J Dermatol Venereol Leprol, 68, pp. 222-224Minota, S., Cameron, B., Welch, W.J., Winfield, D.B., Autoan-tibodies to the constitutive 73 kD member of the hsp70 family of heat shock proteins in SLE (1988) J Exp Med, 168, pp. 1475-1480Ripley, B.J., Isenberg, D.A., Latchman, D.S., Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90 (2001) J Autoimmun, 17, pp. 341-346Kenderov, A., Minkova, V., Mihailova, D., Giltiay, N., Kyurkchiev, S., Kehayov, I., Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies (2002) Clin Exp Immunol, 129, pp. 169-176Villalobos-Hurtado, R., Sanchez-Rogriguez, S.H., Avalos-Diaz, E., Herrera-Esparza, R., Possible role of Hsp70 in autoantigen shuttling to the dermo-epidermal junction in systemic lupus erythematosus (2003) Reumatismo, 55, pp. 155-158Veraldi, S., Rizzitelli, G., Varicella, Koebner phenomenon and psoriasis (1994) Int J Dermatol, 33, pp. 673-674Abraham, A., Farber, E.M., The Koebner response to varicella in psoriasis (1993) Int J Dermatol, 32, pp. 919-920