Effective techniques for local management of unresectable colorectal liver metastases are important tools for a substantial number of patients. Novel approaches and technical improvement of older techniques have been developed to target liver lesions, both in the combined-modality and salvage settings. Irreversible electroporation is a non-thermal technique and can be safely delivered to lesions in the margins of blood vessels, with low risk of vascular disruption. Hepatic embolization consists of selectively treating a hepatic tumor, via its nutrient arterial supply, with one of the following technical variations: bland embolization, chemoembolization, or radioembolization. These techniques have achieved locoregional disease control activity that ultimately may translate into survival gains. 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