Artículos de revistas
Streptozotocin-induced Chromosomal Aberrations, Sces And Mutations In Cho-9 Parental Cells And In Em-c11 Mutant Cell Line
Registro en:
Mutation Research - Fundamental And Molecular Mechanisms Of Mutagenesis. , v. 326, n. 2, p. 227 - 234, 1995.
275107
10.1016/0027-5107(94)00172-2
2-s2.0-0028888633
Autor
Capucci M.S.
Hoffmann M.E.
Zdzienicka M.Z.
Natarajan A.T.
Institución
Resumen
The genotoxic effects induced by the monofunctional nitrosourea derivative steptozotocin (STZ) were investigated in Chinese hamster ovary cells, parental (CHO-9) and its mutant hypersensitive to alkylating agents, designated EM-C11. The ability of this compound to induce chromosomal aberrations, cell killing, sister-chromatid exchanges (SCEs) and mutations was evaluated on these two cell lines. The mutant cells were found to be slightly more sensitive to the killing effects of STZ than the parental cell line. EM-C11 cells also showed higher levels of STZ-induced chromosomal aberrations than CHO-9 cells, but appeared to be equally sensitive to induction of SCEs. 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