Artículos de revistas
Factor V Leiden (fvq 506) Is Common In A Brazilian Population
Registro en:
American Journal Of Hematology. , v. 49, n. 3, p. 242 - 243, 1995.
3618609
10.1002/ajh.2830490312
2-s2.0-0029039978
Autor
Arruda V.R.
Annichino-Bizzacchi M.
Costa F.F.
Reitsma P.H.
Institución
Resumen
Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3-5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population. 49 3 242 243