Artículos de revistas
Mdm2+/cdk4+/p53+ Oral Liposarcoma: Case Report And Review Of The Literature
Registro en:
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, And Endodontics. , v. 92, n. 2, p. 194 - 201, 2001.
10792104
10.1067/moe.2001.116815
2-s2.0-0035433637
Autor
Nikitakis N.G.
Lopes M.A.
Pazoki A.E.
Robert A O.
Sauk J.J.
Institución
Resumen
Although liposarcoma is one of the most common soft tissue sarcomas, its location in the oral cavity is very rare. To our knowledge, only 43 cases of liposarcoma originating in the oral tissues have been reported in the English-language literature. In this article, we report a case of well-differentiated liposarcoma affecting the cheek of a 28-year-old man and review the oral liposarcoma literature. Immunohistochemical analysis of the tumor revealed an MDM2+/CDK4+/p53+ immunophenotype that is consistent with the immunohistochemical profile of well-differentiated liposarcoma originating in other areas of the body. Quantitative polymerase chain reaction analysis of the DNA levels of the MDM2 (human homologue of the murine double-minute type 2), CDK4 (cyclin-dependent kinase 4), and SAS (sarcoma amplified sequence), genes was performed, revealing only SAS gene amplification. The possibility of misdiagnosis of oral liposarcoma because of its sometimes inconspicuous clinical and microscopic features is emphasized. Careful pathologic examination of liposarcoma is essential for discrimination from benign adipose tissue neoplasms and for precise histologic classification, both of major prognostic significance. Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed. 92 2 194 201 Enzinger, F.M., Weiss, S.W., Liposarcoma (1995) Soft Tissue Tumors. 3rd Ed., pp. 431-466. , Gay SM, ed. St Louis: Mosby-Year Book Pack, G.T., Pierson, J.C., Liposarcoma. A study of 105 cases (1954) Surgery, 36, pp. 687-712 Stout, A.P., Liposarcoma - The malignant tumor of lipoblasts (1944) Ann Surg, 119, pp. 86-107 Enterline, H.T., Culberson, J.D., Rochlin, D.B., Brady, L.W., Liposarcoma. A clinical and pathological study of 53 cases (1960) Cancer, 13, pp. 932-950 Hasegawa, H., Kawakami, T., Eda, S., Mixed-type liposarcoma of the oral cavity: A case with unusual features and a long survival (1999) J Oral Pathol Med, 28, pp. 141-144 Sauk J.J., Jr., Liposarcoma of the head and neck (1971) J Oral Surg, 29, pp. 38-40 Henefer, E.P., Borghesani, E.P., Sacks, F.R., Liposarcoma of the cheek (1976) J Oral Surg, 34, pp. 1039-1043 Larson, D.L., Cohn, A.M., Estrada, R.G., Liposarcoma of the tongue (1976) J Otolaryngol, 5, pp. 410-414 Baden, E., Newman, R., Liposarcoma of the oropharyngeal region. Review of the literature and report of two cases (1977) Oral Surg Oral Med Oral Pathol, 44, pp. 889-902 Ramon, Y., Horowitz, Y., Oberman, M., Freedman, A., Liposarcoma of the buccal mucosa (1977) Int J Oral Surg, 6, pp. 226-228 Amarjit, S., Singh, A., Nagpal, B.L., Gambir, G.S., Liposarcoma of the cheek (1978) J Oral Surg, 36, pp. 811-813 Hudson, C., Cove, P., Adekeye, E.O., Liposarcoma of the head and neck: Report of case and review of the literature (1978) J Oral Surg, 36, pp. 380-383 Adkins W.Y., Jr., Putney, F.J., Kreutner, A., Cunningham, C., Liposarcoma of the maxilla (1978) Otolaryngology, 86. , ORL-710-3 Saunders, J.R., Jaques, D.A., Casterline, P.F., Percarpio, B., Goodloe S., Jr., Liposarcomas of the head and neck: A review of the literature and addition of four cases (1979) Cancer, 43, pp. 162-168 Yamada, K., Dohara, Y., Nagata, M., Kawashima, K., Yamashita, S., A case of liposarcoma of the cheek (1979) Jap J Clin Oncol, 9, pp. 123-130 Amarjit, S., Bhardwaj, D.N., Nagpal, B.L., Intraosseous liposarcoma of the maxilla and mandible: Report of two cases (1979) J Oral Surg, 37, pp. 593-596 Sadeghi, E.M., Sauk J.J., Jr., Liposarcoma of the oral cavity. Clinical, tissue culture, and ultrastructure study of a case (1982) J Oral Pathol, 11, pp. 263-275 Suzuki, H., Nagayama, M., Kaneda, T., Oka, T., Liposarcoma of the cheek in an infant (1984) J Oral Maxillofac Surg, 42, pp. 180-184 Wescott, W.B., Correll, R.W., Multiple recurrences of a lesion at the base of the tongue (1984) J Am Dent Assoc, 108, pp. 231-232 Watanabe, I., Satoh, M., Yamane, G., Horiuchi, T., Shimono, M., Liposarcoma arising from the cheek of the aged: Report of a case and review of the literature (1985) Gerodontics, 1, pp. 148-151 Hanada, M., Tokuda, R., Ohnishi, Y., Takami, M., Takahashi, T., Kimura, M., Benign lipoblastoma and liposarcoma in children (1986) Acta Pathol Jpn, 36, pp. 605-612 Dominguez, F.V., Guglielmotti, M.B., Flores, M.C., De La Garza, M.L.G., Myxoid liposarcoma of the cheek (1990) J Oral Maxillofac Surg, 48, pp. 395-397 Eidinger, G., Katsikeris, N., Gullane, P., Liposarcoma: Report of a case and review of the literature (1990) J Oral Maxillofac Surg, 48, pp. 984-988 Charnock, D.R., Jett, T., Heise, G., Taylor, R., Liposarcoma arising in the cheek: Report of a case and review of the literature (1991) J Oral Maxillofac Surg, 49, pp. 298-300 Azaz, B., Casap, N., Myxoid liposarcoma of the buccal vestibule. A case report (1991) Int J Oral Maxillofac Surg, 20, pp. 308-309 Guest, P.G., Liposarcoma of the tongue: A case report and review of the literature (1992) Br J Oral Maxillofac Surg, 30, pp. 268-269 Ruacan, S., Onerci, M., Gedikoglu, G., Dal, T., Liposarcoma of the cheek: Report of a case (1993) J Oral Pathol Med, 22, pp. 46-47 La Quaglia, M.P., Spiro, S.A., Ghavimi, F., Hajdu, S.I., Meyers, P., Exelby, P.R., Liposarcoma in patients younger than or equal to 22 years of age (1993) Cancer, 72, pp. 3114-3119 Lucas, D.R., Nascimento, A.G., Sanjay, B.K.S., Rock, M.G., Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases (1994) Am J Clin Pathol, 102, pp. 677-683 Zheng, J.W., Wang, Y., Liposarcoma in the oral and maxillofacial region: An analysis of 10 consecutive patients (1994) J Oral Maxillofac Surg, 52, pp. 595-598 Nakahara, H., Shirasuna, K., Terada, K., Liposarcoma of the floor of the mouth: A case report (1994) J Oral Maxillofac Surg, 52, pp. 1322-1324 Minic, A.J., Liposarcomas of the oral tissues: A clinicopathologic study of four tumors (1995) J Oral Pathol Med, 24, pp. 180-184 Saddik, M., Oldring, D.J., Mourad, W.A., Liposarcoma of the base of tongue and tonsillar fossa. A possibly underdiagnosed neoplasm (1996) Arch Pathol Lab Med, 120, pp. 292-295 Senyuva, C., Yucel, A., Okur, I., Dervisoglu, S., A well-differentiated giant liposarcoma originating from the buccal fat pad (1996) Ann Plast Surg, 37, pp. 439-443 Kamikaidou, N., Kirita, T., Mishima, K., Sugimura, M., Liposarcoma of the cheek: Report of a case (1998) J Oral Maxillofac Surg, 56, pp. 662-665 Govender, D., Pillay, P., Primary myxoid liposarcoma with rhabdomyoblastic differentiation (1998) Arch Pathol Lab Med, 122, pp. 740-742 Nelson, W., Chuprevich, T., Galbraith, D.A., Enlarging tongue mass (1998) J Oral Maxillofac Surg, 56, pp. 224-227 Gagari, E., Kabani, S., Gallagher, G.T., Intraoral liposarcoma: Case report and review of the literature (2000) Oral Surg Oral Med Oral Pathol Radiol Endod, 89, pp. 66-72 Piattelli, A., Di Alberti, L., Favia, G.F., Liposarcoma involving the periodontal tissues. A case report (2000) J Periodontol, 71, pp. 322-324 Osborn, M., Iseberg, S., Immunocytochemistry of frozen and of paraffin tissue sections (1994) Cell Biology: A Laboratory Handbook, pp. 361-367. , London: Academic Press Sambrook, J., Fritsch, E.F., Maniatis, T., (1989) Molecular Cloning: A Laboratory Manual. 2nd Ed., , Nolan C, ed. New York: Cold Spring Harbor Laboratory Press Golledge, J., Fisher, C., Rhys-Evans, P.H., Head and neck liposarcoma (1995) Cancer, 76, pp. 1051-1058 McCulloch, T.M., Makielski, K.H., McNutt, M.A., Head and neck liposarcoma. A histopathologic reevaluation of reported cases (1992) Arch Otolaryngol Head Neck Surg, 118, pp. 1045-1049 Enzinger, F.M., Weiss, S.W., Liposarcoma (1988) Soft Tissue Tumors. 2nd Ed., pp. 346-382. , Stamathis G, ed. St. Louis: CV Mosby Rosai, J., Akerman, M., Dal Cin, P., DeWever, I., Fletcher, C.D., Mandahl, N., Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (1996) Am J Surg Pathol, 20, pp. 1182-1189. , a report of the CHAMP Study Group Pilotti, S., Della Torre, G., Lavarino, C., Di Palma, S., Sozzi, G., Minoletti, F., Distinct mdm2/p53 expression patterns in liposarcoma subgroups: Implications for different pathogenetic mechanisms (1997) J Pathol, 181, pp. 14-24 Tallini, G., Akerman, M., Dal Cin, P., DeWever, I., Fletcher, C.D., Mandahl, N., Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing (1996) Am J Surg Pathol, 20, pp. 1047-1055. , a report from the CHAMP Group Thelin-Jarnum, S., Lassen, C., Panagopoulos, I., Mandahl, N., Aman, P., Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas (1999) Int J Cancer, 83, pp. 30-33 Dei Tos, A.P., Doglioni, C., Piccinin, S., Maestro, R., Mentzel, T., Barbareschi, M., Molecular abnormalities of the p53 pathway in dedifferentiated liposarcomas (1997) J Pathol, 181, pp. 8-13 Hisaoka, M., Tsuji, S., Morimitsu, Y., Hashimoto, H., Shimajiri, S., Komiya, S., Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues (1998) Diagn Mol Pathol, 7, pp. 96-101 Pilotti, S., Della Torre, G., Lavarino, C., Sozzi, G., Minoletti, F., Vergani, B., Molecular abnormalities in liposarcoma: Role of MDM2 and CDK4-containing amplicons at 12q13-22 (1998) J Pathol, 185, pp. 188-190 Leach, F.S., Tokino, T., Meltzer, P., Burrell, M., Oliner, J.D., Smith, S., p53 mutation and MDM2 amplification in human soft tissues sarcomas (1993) Cancer Res, 53, pp. 2231-2234 Nakayama, T., Toguchida, J., Wadayama, B., Kanoe, H., Kotoura, Y., Sasaki, M.S., MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adipose-tissue tumors (1995) Int J Cancer, 64, pp. 342-346 Nilbert, M., Rydholm, A., Mitelman, F., Meltzer, P.S., Mandahl, N., Characterization of the 12q13-15 amplicon in soft tissue tumors (1995) Cancer Genet Cytogenet, 83, pp. 32-36 Kanoe, H., Nakayama, T., Murakami, H., Hosaka, T., Yamamoto, H., Nakashima, Y., Amplification of the CDK4 gene in sarcomas: Tumor specificity and relationship with the RB gene mutation (1998) Anticancer Res, 18, pp. 2317-2321 Jankowski, S.A., Mitchell, D.S., Smith, S.H., Trent, J.M., Meltzer, P.S., SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins (1994) Oncogene, 9, pp. 1205-1211 Jankowski, S.A., De Jong, P., Meltzer, P.S., Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas (1995) Genomics, 25, pp. 501-506 Pilotti, S., Lavarino, C., Mezzelani, A., Della Torre, C., Minoletti, F., Sozzi, G., Limited role of TP53 and TP53-related genes in myxoid liposarcoma (1998) Tumori, 84, pp. 571-577 Dei Tos, A.P., Piccinin, S., Doglioni, C., Vukosavljevic, T., Mentzel, T., Boiocchi, M., Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma (1997) Am J Pathol, 151, pp. 1531-1539