Artículos de revistas
Low Protein Diet Confers Resistance To The Inhibitory Effects Of Interleukin 1β On Insulin Secretion In Pancreatic Islets
Registro en:
Journal Of Nutritional Biochemistry. , v. 12, n. 5, p. 285 - 291, 2001.
9552863
10.1016/S0955-2863(01)00140-1
2-s2.0-0035005142
Autor
Vieira E.C.
Carneiro E.M.
Latorraca M.Q.
Delguingaro-Augusto V.
Amaral M.E.C.
Bosqueiro J.R.
Boschero A.C.
Institución
Resumen
High protein content in the diet during childhood and adolescence has been associated to the onset insulin-dependent diabetes mellitus. We investigated the effect of interleukin-1β (IL-1β) on insulin secretion, glucose metabolism, and nitrite formation by islets isolated from rats fed with normal protein (NP, 17%) or low protein (LP, 6%) after weaning. Pretreatment of islets with IL-1β for 1 h or 24 h inhibited the insulin secretion induced by glucose in both groups, but it was less marked in LP than in NP group. Islets from LP rats exhibited a decreased IL-1β-induced nitric oxide (NO) production, lower inhibition of D-[U14C]-glucose oxidation to 14CO2 and less pronounced effect of IL-1β on α-ketoisocaproic acid-induced insulin secretion than NP islets. However, when the islets were stimulated by high concentrations of K+ the inhibitory effect of IL-1β on insulin secretion was not different between groups. 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