Actas de congresos
Preparation And Characterization Of A New Hplc C18 Reversed Phase Containing Thiocarbamate Groups
Registro en:
Microchemical Journal. , v. 82, n. 2, p. 150 - 158, 2006.
0026265X
10.1016/j.microc.2006.01.012
2-s2.0-33644968571
Autor
Silva R.B.
Silva C.R.
Airoldi C.
Collins C.H.
Jardim I.C.S.F.
Institución
Resumen
A HPLC stationary phase that possesses an internal thiocarbamate functional group is described. The new C18-thiocarbamate silane was synthesized by the reaction of a trifunctional alkoxysilane with a mercaptan. The silylant agent was bonded to silica (5 μm) and the new stationary phase was then endcapped. Surface characteristics of the packing before and after chemical modification with HMDS and TMCS were determined by different physico-chemical methods, such as elemental analysis and infrared and solid-state 13C and 29Si nuclear magnetic resonance spectroscopies. Chromatographic properties of the C18-thiocarbamate silica were evaluated under reversed phase conditions by separation of four different test mixtures that including compounds from the Engelhardt, Tanaka, and Neue test mixtures. Chromatographic evaluations of the C18-thiocarbamate phase show promising results for the separation of basic analytes. © 2006 Elsevier B.V. All rights reserved. 82 2 150 158 Nomura, A., Yamada, J., Tsunoda, K., (1987) Anal. Sci., 3, p. 209 Ascah, L.T., Feibush, B., (1990) J. Chromatogr., 506, p. 357 Ascah, T.L., Kallury, K.M.R., Szafranski, C.A., Corman, S.D., Liu, F., (1996) J. Liq. Chromatogr. Relat. Technol., 19, p. 3049 Buszewski, B., Schmidt, J., Albert, K., Bayer, E., (1991) J. Chromatogr., 552, p. 415 Buszewski, B., Kasturi, P., Gilpin, R.K., Gangoda, M.E., Jaroniec, M., (1994) Chromatographia, 39, p. 155 Buszewski, B., Jaroniec, M., Gilpin, R.K., (1994) J. Chromatogr., a, 668, p. 293 Czajkowska, T., Hrabovsky, I., Buszewski, B., Gilpin, R.K., Jaroniec, M., (1997) J. Chromatogr., a, 691, p. 3277 O'Gara, J.E., Alden, B.A., Walter, T.H., Petersen, J.S., Niederlander, C.K., Neue, U.D., (1995) Anal. Chem., 67, p. 3809 O'Gara, J.E., Walsh, D.P., Alden, B.A., Casellini, P., Walter, T.H., (1999) Anal. Chem., 71, p. 2992 O'Gara, J.E., Walsh, D.P., Phoebe Jr., C.H., Alden, B.A., Bouvier, E.S., Iraneta, P.C., Capparella, M., Walsh, T.H., (2001) LC-GC No. Am., 19, p. 632 Silva, C.R., Jardim, I.C.S.F., Airoldi, C., (2001) J. Chromatogr., a, 913, p. 65 Silva, C.R., Bachmann, S., Schefer, R.R., Albert, K., Jardim, I.C.S.F., Airoldi, C., (2002) J. Chromatogr., a, 948, p. 85 Silva, C.R., Jardim, I.C.S.F., Airoldi, C., (2003) J. Chromatogr., a, 987, p. 127 Silva, C.R., Jardim, I.C.S.F., Airoldi, C., (2003) J. Chromatogr., a, 987, p. 139 Silva, C.R., Collins, C.H., Jardim, I.C.S.F., Airoldi, C., (2004) J. Chromatogr., a, 1030, p. 157 Silva, C.R., Airoldi, C., Collins, K.E., Collins, C.H., (2005) J. Chromatogr., a, 1087, p. 29 Horak, J., Maier, N.M., Lindner, W., (2004) J. Chromatogr., a, 1045, p. 43 Horak, J., Lindner, W., (2004) J. Chromatogr., a, 1043, p. 177 O'Gara, J.E., Walsh, D.P., Phoebe Jr., C.H., Alden, B.A., Bouvier, E.S.P., Iraneta, P.C., Capparella, M., Walter, T.H., (2001) LC-GC No. Am., 19, p. 632 Kinkel, J.N., Unger, K.K., (1984) J. Chromatogr., 316, p. 193 Engelhardt, H., Orth, P., (1987) J. Liq. Chromatogr. Relat. Technol., 10, p. 1999 Collins, K.E., Franchon, A.C., Jardim, I.C.S.F., Radonovic, E., Gonçalves, M.C., (2000) LC-GC No. Am., 18, p. 106 Engelhardt, H., Arangio, M., Lobert, T., (1997) LC-GC, 15, p. 856 Kimata, K., Iwaguchi, K., Onishi, S., Jinno, K., Eksteen, R., Hosoya, K., Araki, M., Tanaka, N., (1989) J. Chromatogr. Sci., 27, p. 721 Neue, U.D., Serowik, E., Iraneta, P., Alden, B.A., Walter, T.H., (1999) J. Chromatogr., a, 849, p. 87 Berendsen, G.E., Pikart, K.A., De Galan, L., (1980) J. Liq. Chromatogr., 3, p. 1437 Silva, C.R., Airoldi, C., Collins, K.E., Collins, C.H., (2005) J. Chromatogr., a, 1073, p. 155 Bachmann, S., Melo, L.F.C., Silva, R.B., Anazawa, T.A., Jardim, I.C.S.F., Collins, K.E., Collins, C.H., Albert, K., (2001) Chem. Mater., 13, p. 1874 Albert, K., (2003) J. Sep. Sci., 26, p. 215 Bugey, A., Staub, C., (2004) J. Pharm. Biomed. Anal., 35, p. 555