Artículos de revistas
Antiproliferative Activity And Induction Of Apoptosis In Pc-3 Cells By The Chalcone Cardamonin From Campomanesia Adamantium (myrtaceae) In A Bioactivity-guided Study
Registro en:
Molecules. , v. 19, n. 2, p. 1843 - 1855, 2014.
14203049
10.3390/molecules19021843
2-s2.0-84894640317
Autor
Pascoal A.C.R.F.
Ehrenfried C.A.
Lopez B.G.-C.
De Araujo T.M.
Pascoal V.D.B.
Gilioli R.
Anhee G.F.
Ruiz A.L.T.G.
De Carvalho J.E.
Stefanello M.A.
Salvador M.J.
Institución
Resumen
The Myrtaceae family is a common source of medicines used in the treatment of numerous diseases in South America. In Brazil, fruits of the Campomanesia species are widely used to make liqueurs, juices and sweets, whereas leaves are traditionally employedas a medicine for dysentery, stomach problems, diarrhea, cystitis and urethritis. Ethanol extracts of Campomanesia adamantium (Myrtaceae) leaves and fruits were evaluated against prostate cancer cells (PC-3). The compound (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3- phenylprop-2-en-1-one, cardamonin) was isolated from ethanol extracts of C. adamantium leaves in a bioactivity-guided study and quantified by UPLC-MS/MS. In vitro studies showed that the isolated chalcone cardamonin inhibited prostate cancer cell proliferation and decreased the expression of NFkB1. 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