Artículos de revistas
Cumulative Organ Damage Evaluation Using The Slicc/acr-di In Brazilian Patients With Systemic Lupus Erythematosus [avaliação Do índice De Danos Permanentes Através Do Slicc/acr-di Em Pacientes Brasileiros Com Lúpus Eritematoso Sistêmico]
Registro en:
Revista Brasileira De Reumatologia. , v. 44, n. 2, p. 109 - 114, 2004.
4825004
2-s2.0-33846695127
Autor
Guarize J.
Appenzeller S.
Costallat L.T.L.
Institución
Resumen
Objective: to evaluate the frequency and the different types of organ damage in relation to disease duration in Brazilian patients with SLE followed in a tertiary reference center through the application of the SLICC/ACR-DI. Methods: sixty SLE patients were enrolled in this study, and relevant data were obtained through medical history, physical and laboratory examinations reviewing the hospital records. The frequency and different types of organ damage were determined using the SLICC/ACR-DI. Statistics were performed through qui-square and t-tests. Multivariate regression was used to correlate damage with disease duration. Results: forty-one patients (68.3%) presented some cumulative organ damage. Non-caucasoid patients and patients with longer disease duration had a slight tendency to have more damage (p = 0.058). Skin (35.0%), neuropsychiatric (18.3%), ocular (15.0%), peripheral vascularization (16.6%) and cardiovascular (10.0%) systems were more frequently affected. Patients with more than 60 months of disease had a slight tendency to present greater ocular, neuropsychiatric, renal, skin and musculoskeletal damage than patients with shorter disease duration. Patients with more than 120 months of disease had greater pulmonary, cardiovascular and peripheral vascular damage. Conclusions: in this study, 68.3% of permanent damage was observed. Skin, neuropsychiatric, ocular, peripheral vascularization and cardiovascular systems were more frequently affected. Renal and gonadal involvement was not as frequent as previously described. Non-caucasoid patients had a tendency to present higher scores, but more studies are necessary to determinate if ethnic or economic factors are involved. 44 2 109 114 Cervera, R., Khamashta, M.A., Font, J., Morbidity and mortality in systemic lupus erythematosus during a 10-year period: A comparison of early and late manifestations in a cohort of 1,000 patients (2003) Medicine, 82, pp. 299-308. , (Baltimore) Moss, K.E., Ioannou, Y., Sultan, S.M., Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades (2002) Ann Rheum Dis, 61, pp. 409-413 Trager, J., Ward, M.M., Mortality and causes of death in systemic lupus erythematosus (2001) Curr Opin Rheumatol, 13, pp. 345-351 Petri, M., Hopkins lupus cohort (2000) Rheum Dis Clin North Am, 26, pp. 199-213 Gladman, D., Glinzler, E., Goldsmith, C., The development and initial validation of the Systemic lupus International Collaborating Clinics/ American College of Rheumatology damage index for systemic lupus erythematosus (1996) Arthritis Rheum, 39, pp. 363-378 Zonana-Nacach, A., Camargo-Coronel, A., Yanez, P., Measurement of damage in 210 mexican patients with systemic lupus erythematosus: Relationship with disease duration (1998) Lupus, 7, pp. 119-123 Tan, E.M., Cohen, A.S., Fries, J.F., The 1982 revised criteria for the classification of systemic lupus erythematosus (1982) Arthritis Rheum, 25, pp. 1271-1277 Folstein, M.F., Folstein, S.E., Folstein, P.R., "Mini mental state" A practical method for grading the cognitive state of patient for the clinician (1975) J Psychiatr Res, 12, pp. 189-198 Appenzeller, S., Fujisawa, G., Costallat, L.T.L., Distúrbios cognitivos no lúpus eritematoso sistêmico (1999) Rev Bras Reumatol, 39, pp. 12-18 Rahman, P., Glagman, D.D., Urowitz, M.B., Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus (2001) Lupus, 10, pp. 93-96 Stoll, T., Seifert, B., Isenberg, D.A., SLICC/ACR damage index is valid, and renal and pulmonary organ scores are predictors of severe outcome in patients with SLE (1996) Br J Rheumatol, 35, pp. 248-245 Stoll, T., Stucki, G., Malik, J., Association of the SLICC/ACR damage index with measures of disease activity and health status in patients with SLE (1997) J Rheumatol, 24, pp. 309-313 Zonana-Nacach, A., Barr, S.G., Magder, L.S., Damage in systemic lupus erythematosus and its association with corticosteroids (2000) Arthritis Rheum, 43, pp. 1801-1808 Gorgos, L., Goldman, D., Petri, M., The ACR/SLICC damage index in SLE (1993) Arthritis Rheum, 36, pp. S68 Karlson, E.W., Daltroy, L.H., Lew, R.A., The relationship of socioeconomic status, race, and modifiable risk factor to outcomes in patientes with SLE (1996) Arthritis Rheum, 40, pp. 47-56