Inflammatory Effects Of Snake Venom Myotoxic Phospholipases A2

dc.creatorTeixeira C.F.P.
dc.creatorLanducci E.C.T.
dc.creatorAntunes E.
dc.creatorChacur M.
dc.creatorCury Y.
dc.date2003
dc.date2015-06-30T17:32:59Z
dc.date2015-11-26T14:12:29Z
dc.date2015-06-30T17:32:59Z
dc.date2015-11-26T14:12:29Z
dc.date.accessioned2018-03-28T21:13:07Z
dc.date.available2018-03-28T21:13:07Z
dc.identifierToxicon. , v. 42, n. 8, p. 947 - 962, 2003.
dc.identifier10.1016/j.toxicon.2003.11.006
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-1042298831&partnerID=40&md5=451f59211c65fcde6b90bfff1e0af790
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102611
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102611
dc.identifier2-s2.0-1042298831
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242009
dc.descriptionSnake venom phospholipases A2 (PLA2) show a remarkable functional diversity. Among their toxic activities, some display the ability to cause rapid necrosis of skeletal muscle fibers, thus being myotoxic PLA2s. Besides myotoxicity, these enzymes evoke conspicuous inflammatory and nociceptive events in experimental models. Local inflammation and pain are important characteristics of snakebite envenomations inflicted by viperid and crotalid species, whose venoms are rich sources of myotoxic PLA 2s. Since the discovery that mammalian PLA2 is a key enzyme in the release of arachidonic acid, the substrate for the synthesis of several lipid inflammatory mediators, much interest has been focused on this enzyme in the context of inflammation. The mechanisms involved in the proinflammatory action of secretory PLA2s are being actively investigated, and part of the knowledge on secretory PLA2 effects has been gained by using snake venom PLA2s as tools, due to their high structural homology with human secretory PLA2s. The inflammatory events evoked by PLA2s are primarily associated with enzymatic activity and to the release of arachidonic acid metabolites. However, catalytically inactive Lys49 PLA2s trigger inflammatory and nociceptive responses comparable to those of their catalytically active counterparts, thereby evidencing that these proteins promote inflammation and pain by mechanisms not related to phospholipid hydrolysis nor to mobilization of arachidonic acid. These studies have provided a boost to the research in this field and various approaches have been used to identify the amino acid residues and the specific sites of interaction of myotoxic PLA2s with cell membranes potentially involved in the PLA2-induced inflammatory and nociceptive effects. This work reviews the proinflammatory and nociceptive effects evoked by myotoxic PLA2s and their mechanisms of action. © 2004 Published by Elsevier Ltd.
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dc.descriptionAbbott, F.V., Guy, E.R., Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: Sedation versus specific suppression of pain (1995) Pain, 62, pp. 303-312
dc.descriptionAbbott, F.V., Hong, Y., Blier, P., Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin 2A receptors (1997) Neuroscience, 77, pp. 575-584
dc.descriptionAderem, A., Underhill, D.M., Mechanisms of phagocytosis in macrophages (1999) Annu. Rev. Immunol., 17, pp. 523-593
dc.descriptionAkopian, A.N., Sivilotti, L., Wood, J.N., A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons (1996) Nature, 379, pp. 257-262
dc.descriptionAlam, R., Lett-Brown, M.A., Forsythe, P.A., Anderson-Walters, D.J., Kenamore, C., Kormos, C., Monocyte chemotactic and activating factor (MCAF) is a potent histamine-releasing factor for basophils (1992) J. Clin. Invest., 89, pp. 723-728
dc.descriptionAllen, A.C., Gammon, C.M., Ousley, A.H., McCarthy, K.D., Morell, P., Bradykinin stimulates arachidonic acid release through the sequential actions of an sn-1 diacylglycerol lipase and a monoacylglycerol lipase (1992) J. Neurochem., 58, pp. 1130-1139
dc.descriptionAntunes, E., Mariano, M., Cirino, G., Levi, S., De Nucci, G., Pharmacological characterization of polycation-induced rat hind-paw oedema (1990) Br. J. Pharmacol., 101 (4), pp. 986-990
dc.descriptionAppleton, I., Tomlinson, A., Willoughby, D.A., Induction of cyclo-oxygenase and nitric oxide synthase in inflammation (1996) Adv. Pharmacol., 35, pp. 27-79
dc.descriptionArroyo, O., Rojas, G., Gutiérrez, J.M., Envenenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas (1996) Acta Médica Costarricense, 41, pp. 23-29
dc.descriptionBalsinde, J., Balboa, M.A., Dennis, E.A., Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A 2 (1998) Proc. Natl. Acad. Sci. USA, 95 (14), pp. 7951-7956
dc.descriptionBeghini, D.G., Toyama, M.H., Hyslop, S., Sodek, L.C., Novello, J.C., Marangoni, S., Enzymatic characterization of a novel phospholipase A2 from Crotalus durissus cascavella rattlesnake (Maracamboia) venom (2000) J. Protein Chem., 19 (8), pp. 679-684
dc.descriptionBomalaski, J.S., Lawton, P., Browning, J.L., Human extracellular recombinant phospholipase A2 induces an inflammatory response in rabbit joints (1991) J. Immunol., 146, pp. 3904-3910
dc.descriptionMezey, E., Toth, Z.E., Cortright, D.N., Arzubi, M.K., Krause, J.E., Elde, R., Guo, A., Szallasi, A., Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 3655-3660
dc.descriptionMillan, M.J., The induction of pain: An integrative review (1999) Prog. Neurobiol., 57, pp. 1-164
dc.descriptionMizumura, K., Minagawa, M., Koda, H., Kumazawa, T., Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro (1995) Inflamm. Res., 44, pp. 376-378
dc.descriptionMoore, P.A., Hersh, E.V., Celecoxib and rofecoxib. The role of COX-2 inhibitors in dental practice (2001) J. Am. Dent. Assoc., 132, pp. 451-456
dc.descriptionMoreno, J.J., Ferrer, X., Ortega, E., Carganico, G., PLA2 induced oedema in rat skin and histamine release in rat mast cells. Evidence for involvement of lysophospholipids in the mechanism of action (1992) Agents Actions, 36, pp. 258-263
dc.descriptionMukherjee, A.B., Miele, L., Pattabiraman, N., Phospholipase A2 enzymes: Regulation and physiological role (1994) Biochem. Pharmacol., 48, pp. 1-10
dc.descriptionMurakami, M., Kambe, T., Shimbara, S., Yamamoto, S., Kuwata, H., Kudo, I., Functional association of type IIA secretory phospholipase A2 with the glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan in the cyclooxygenase-2-mediated delayed prostanoid-biosynthetic pathway (1999) J. Biol. Chem., 274, pp. 29927-29936
dc.descriptionNagai, H., Sakamoto, T., Kondo, M., Miura, T., Inagaki, N., Koda, A., Extracellular phospholipase A2 and histamine release from rat peritoneal mast cells (1991) Int. Arch. Allergy Appl. Immunol., 96 (4), pp. 311-316
dc.descriptionNair, X., Nettleton, D., Clever, D., Tramposch, K.M., Ghosh, S., Franson, R.C., Swine as a model of skin inflammation. Phospholipase A 2-induced inflammation (1993) Inflammation, 17 (2), pp. 205-215
dc.descriptionColeman, J.W., Holgate, S.T., Church, M.K., Godfrey, R.C., Immunoglobulin e decapeptide-induced 5-hydroxytryptamine release from rat peritoneal mast cells (1981) Biochem. J., 198, pp. 615-619
dc.descriptionNakae, H., Endo, S., Inada, K., Yamashita, H., Yamada, Y., Takakuwa, T., Kasai, T., Uchida, K., Plasma concentrations of type II phospholipase A2, cytokines and eicosanoids in patients with burns (1995) Burns, 21, pp. 422-426
dc.descriptionBonta, I.L., Vargaftig, B.B., Bohm, G.M., Handbook of experimental pharmacology (1979) Snake Venoms, 52, pp. 629-683. , Lee C.Y
dc.descriptionNakamura, M., Ferreira, S.H., A peripheral sympathetic component in inflammatory hyperalgesia (1987) Eur. J. Pharmacol., 135, pp. 145-153
dc.descriptionNeedham, L., Hellewell, P.G., Williams, T.J., Gordon, J.L., Endothelial functional responses and increased vascular permeability induced by polycations (1988) Lab. Invest., 59 (4), pp. 538-548
dc.descriptionNevalainen, T.J., Haapamaki, M.M., Gronroos, J.M., Roles of secretory phospholipases A2 in inflammatory diseases and trauma (2000) Biochim. Biophys. Acta, 1488, pp. 83-90
dc.descriptionNúñez, C.E., Angulo, Y., Lomonte, B., Identification of the myotoxic site of the Lys49 phospholipase A 2 from Agkistrodon piscivorus piscivorus snake venom: Synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities (2001) Toxicon, 39, pp. 1587-1594
dc.descriptionOhsaka, A., Hemorrhagic, necrotizing and edema-forming effects of snake venoms (1979) Handbook of Experimental Pharmacology. Snake Venoms, 52, pp. 480-546. , C.Y. Lee. Berlin: Springer
dc.descriptionOshima-Franco, Y., Leite, G.B., Silva, G.H., Cardoso, D.F., Hyslop, S., Giglio, J.R., Da Cruz-Hofling, M.A., Rodrigues-Simioni, L., Neutralization of the pharmacological effects of bothropstoxin-I from Bothrops jararacussu (jararacucu) venom by crotoxin antiserum and heparin (2001) Toxicon, 39 (10), pp. 1477-1485
dc.descriptionOwnby, C.L., Selistre-De-Araujo, H.S., White, S.P., Fletcher, J.E., Lysine 49 phospholipase A2 proteins (1999) Toxicon, 37, pp. 411-445
dc.descriptionOzaktay, A.C., Kallakuri, S., Cavanaugh, J.M., Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion (1998) Spine, 23, pp. 1297-1306
dc.descriptionCunha, F.Q., Lorenzetti, B.B., Poole, S., Ferreira, S.H., Interleukin-8 as a mediator of sympathetic pain (1991) Br. J. Pharmacol., 104, pp. 765-767
dc.descriptionPadawer, J., Cytological studies on normal and surviving mast cells in vitro (1970) Am. J. Anat., 127 (2), pp. 159-179
dc.descriptionPage, I.H., The discovery of serotonin (1976) Perspect. Biol. Med., 20, pp. 1-8
dc.descriptionBowton, D.L., Seeds, M.C., Fasano, M.B., Goldsmith, B., Bass, D.A., Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics (1997) Am. J. Resp. Crit. Care Med., 155, pp. 421-425
dc.descriptionParada, C.A., Vivancos, G.G., Tambeli, C.H., De Queiroz Cunha, F., Ferreira, S.H., Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 2923-2928
dc.descriptionPáramo, L., Lomonte, B., Pizarro-Cerda, J., Bengoechea, J.A., Gorvel, J.P., Moreno, E., Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A 2 from Bothrops asper snake venom - Synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region (1998) Eur. J. Biochem., 253, pp. 452-461
dc.descriptionPereira, M.F., Novello, J.C., Cintra, A.C., Giglio, J.R., Landucci, E.T., Oliveira, B., Marangoni, S., The amino acid sequence of bothropstoxin-II, an Asp-49 myotoxin from Bothrops jararacussu (Jararacucu) venom with low phospholipase A2 activity (1998) J Protein Chem., 17, pp. 381-386
dc.descriptionPinheiro, R.M., Campos, M.M., Calixto, J.B., Analysis of the mechanisms involved in the inflammatory response induced by des-Arg9-bradykinin in the rat pleural cavity (2001) Inflamm. Res., 50, pp. 570-576
dc.descriptionPiperno, M., Hellio Le Graverand, M.P., Reboul, P., Mathieu, P., Tron, A.M., Perrin, G., Peschard, M.J., Vignon, E., Phospholipase A2 activity in herniated lumbar discs. Clinical correlation and inhibition by piroxicam (1997) Spine, 22, pp. 2061-2065
dc.descriptionPoole, S., Lorenzetti, B.B., Cunha, J.M., Cunha, F.Q., Ferreira, S.H., Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia (1999) Br. J. Pharmacol., 126, pp. 649-656
dc.descriptionProud, D., Kaplan, A.P., Kinin formation: Mechanisms and role in inflammatory disorders (1988) Annu. Rev. Immunol., 6, pp. 49-83
dc.descriptionCunha, F.Q., Poole, S., Lorenzetti, B., Ferreira, S.H., The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia (1992) Br. J. Pharmacol., 107, pp. 660-664
dc.descriptionProud, D., Togias, A., Naclerio, R.M., Crush, S.A., Norman, P.S., Lichtenstein, L.M., Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen (1983) J. Clin. Invest., 72, pp. 1678-1685
dc.descriptionPruzanski, W., Saito, S., Stefanski, E., Vadas, P., Comparison of group I and II soluble phospholipases A2 activities on phagocytic functions of human polymorphonuclear and mononuclear phagocytes (1991) Inflammation, 15, pp. 127-135
dc.descriptionRabinovitch, M., De Stefano, M.J., Macrophage spreading in vitro. I. Inducers of spreading (1973) Exp. Cell. Res., 77, pp. 323-334
dc.descriptionBrain, S.D., Whittle, B.J.E., Action of phospholipase A2 on mast cell histamine release and paw oedema in rat (1977) Br. J. Pharmacol., 59. , 440 pp
dc.descriptionReasbeck, P.G., Rice, M.L., Reasbeck, J.C., Double-blind controlled trial of indomethacin as an adjunct to narcotic analgesia after major abdominal surgery (1982) Lancet, 2, pp. 115-118
dc.descriptionRegoli, D.C., Marceau, F., Lavigne, J., Induction of B1 receptors for kinins in the rabbit by a bacterial lipopolysaccharide (1981) Eur. J. Pharmacol., 71, pp. 105-115
dc.descriptionRen, K., Dubner, R., NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw (1993) Neurosci. Lett., 163, pp. 22-26
dc.descriptionRichardson, B.P., Engel, G., The pharmacology and function of 5-HT3 receptors (1986) Trends Neurosci., 9, pp. 424-427
dc.descriptionRiedel, W., Neeck, G., Nociception, pain, and antinociception: Current concepts (2001) J. Rheumatol., 60, pp. 404-415
dc.descriptionRizzo, M.T., Nguyen, E., Aldo-Benson, M., Lambeau, G., Secreted phospholipase A2 induces vascular endothelial cell migration (2000) Blood, 96, pp. 3809-3815
dc.descriptionCury, Y., Chacur, M., Longo, I., Lomonte, B., Gutiérrez, J.M., (2002) Structural Mechanisms of Pain Induced by Asp49 and Lys49 Myotoxic Phospholipases A2 (PLA2) Isolated from Bothrops Asper Venom. IASP (International Association for the Study on Pain), 10th World Congress on Pain, Abstracts, , p. 150
dc.descriptionRojas, G., Gutiérrez, J.M., Gené, J.A., Gómez, M., Cerdas, L., Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica (1987) Rev. Biol. Trop., 35, pp. 59-67
dc.descriptionRosenberg, P., Pharmacology of phospholipase A2 from snake venoms (1979) Handbook of Experimental Pharmacology. Snake Venoms, 52, p. 403. , C.Y. Lee. Berlin: Springer
dc.descriptionRoy, M.L., Narahashi, T., Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons (1992) J. Neurosci., 12, pp. 2104-2111
dc.descriptionRyan, G.B., Majno, G., Antiinflammation. A review (1977) Am. J. Pathol., 86, pp. 183-276
dc.descriptionCaffrey, J.M., Eng, D.L., Black, J.A., Waxman, S.G., Kocsis, J.D., Three types of sodium channels in adult rat dorsal root ganglion neurons (1992) Brain Res., 592, pp. 283-297
dc.descriptionSaal, J.A., Saal, J.S., Herzog, R.J., The natural history of lumbar intervertebral disc extrusions treated nonoperatively (1990) Spine, 15, pp. 683-686
dc.descriptionSaegusa, H., Matsuda, Y., Tanabe, T., Effects of ablation of N- and R-type Ca2+channels on pain transmission (2002) Neurosci. Res., 43, pp. 1-7
dc.descriptionSamuelsson, B., Dahlen, S.E., Lindgren, J.A., Rouzer, C.A., Serhan, C.N., Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects (1987) Science, 237, pp. 1171-1176
dc.descriptionSann, H., Jancso, G., Rossler, W., Pierau, F.K., Reduction of sub stance P binding sites in the spinal dorsal horn after perineural capsaicin treatment in the rat (1995) Neurosci. Lett., 190, pp. 151-154
dc.descriptionSantana, A., Hyslop, S., Antunes, E., Mariano, M., Bakhle, Y.S., De Nucci, G., Inflammatory responses induced by poly-L-arginine in rat lungs in vivo (1993) Agents Actions, 39 (3-4), pp. 104-110
dc.descriptionDahinden, C.A., Geiser, T., Brunner, T., Von Tscharner, V., Caput, D., Ferrara, P., Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine (1994) J. Exp. Med., 79, pp. 751-756
dc.descriptionSchroder, T., Kivilaakso, E., Kinnunen, P.K., Lempinen, M., Serum phospholipase A2 in human acute pancreatitis (1980) Scand. J. Gastroenterol., 15, pp. 633-636
dc.descriptionSchwartz, L.B., Mast cells: Function and contents (1994) Curr. Opin. Immunol., 6 (1), pp. 91-97
dc.descriptionScott, K.F., Bryant, K.J., Bidgood, M.J., Functional coupling and differential regulation of the phospholipase A2-cyclooxygenase pathways in infla
dc.descriptionCalderón, L., Lomonte, B., Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom (1998) Arch. Biochem. Biophys., 358, pp. 343-350
dc.descriptionCalderón, L., Lomonte, B., Inhibition of the myotoxic activity of Bothrops asper myotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129 (1999) Toxicon, 37, pp. 683-687
dc.descriptionCao, Y.Q., Mantyh, P.W., Carlson, E.J., Gillespie, A.M., Epstein, C.J., Basbaum, A.I., Primary afferent tachykinins are required to experience moderate to intense pain (1998) Nature, 392, pp. 390-394
dc.descriptionCastro, R.C., Landucci, E.C., Toyama, M.H., Giglio, J.R., Marangoni, S., De Nucci, G., Antunes, E., Leucocyte recruitment induced by type II phospholipases A2 into the rat pleural cavity (2000) Toxicon, 38 (12), pp. 1773-1785
dc.descriptionChacur, M., Picolo, G., Gutiérrez, J.M., Teixeira, C.F.P., Cury, Y., Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom (2001) Toxicon, 39, pp. 1173-1181
dc.descriptionChacur, M., Longo, I., Picolo, G., Gutiérrez, J.M., Lomonte, B., Guerra, J.L., Teixeira, C.F., Cury, Y., Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: Pharmacological mediation and molecular determinants (2003) Toxicon, 41, pp. 667-678
dc.descriptionChandrasekharan, N.V., Dai, H., Roos, K.L.T., Evanson, N.K., Tomsik, J., Elton, T.S., Simmons, D.L., COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 13926-13931
dc.descriptionDamerau, B., Lege, L., Oldigs, H.D., Vogt, W., Histamine release, formation of prostaglandin-like activity (SRS-C) and mast cell degranulation by the direct lytic factor (DLF) and phospholipase a of cobra venom (1975) Naunyn Schmiedebergs Arch. Pharmacol., 287, pp. 141-156
dc.descriptionChaves, F., León, G., Alvarado, V.H., Gutiérrez, J.M., Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo) (1998) Toxicon, 36, pp. 1861-1869
dc.descriptionChen, C., Cavanaugh, J.M., Ozaktay, A.C., Kallakuri, S., King, A.L., Effects of phospholipases A2 on lumbar nerve root structure and function (1997) Spine, 22, pp. 1057-1064
dc.descriptionChoi, S.H., Sakamoto, T., Fukutomi, O., Inagaki, N., Matsuura, N., Nagai, H., Koda, A., Pharmacological study of phospholipase A2-induced histamine release from rat peritoneal mast cells (1989) J. Pharmacobiodyn., 12 (9), pp. 517-522
dc.descriptionCintra, A.C.O., Marangoni, S., Oliveira, B., Giglio, J.R., Bothropstoxin-I: Amino acid sequence and function (1993) J. Protein Chem., 12, pp. 57-64
dc.descriptionCirino, G., Peers, S.H., Wallace, J.L., Flower, R.J., A study of phospholipase A2-induced oedema in rat paw (1989) Eur. J. Pharmacol., 166, pp. 505-510
dc.descriptionCirino, G., Cicala, C., Sorrentino, L., Maiello, F.M., Browning, J.L., Recombinant secreted nonpancreatic phospholipase A2 induces a synovitis-like inflammation in the rat air pouch (1994) J. Rheumatol., 21 (5), pp. 824-829
dc.descriptionCoderre, T.J., Melzack, R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury (1992) J. Neurosci., 12, pp. 3665-3670
dc.descriptionColburn, R.W., Rickman, A.J., Deleo, J.A., The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behaviour (1999) Exp. Neurol., 157, pp. 289-304
dc.descriptionDaniele, J.J., Bianco, I.D., Delgado, C., Carrillo, D.B., Fidelio, G.D., A new phospholipase A2 isoform isolated from Bothrops neuwiedii (Yarara chica) venom with novel kinetic and chromatographic properties (1997) Toxicon, 35 (8), pp. 1205-1215
dc.descriptionDennis, E.A., Diversity of group types, regulation, and function of phospholipase A2 (1994) J. Biol. Chem., 269 (18), pp. 13057-13060
dc.descriptionDevillier, P., Renoux, M., Giroud, J.P., Regoli, D., Peptides and histamine release from rat peritoneal mast cells (1985) Eur. J. Pharmacol., 117, pp. 89-96
dc.descriptionDevor, M., The pathophysiology of damaged peripheral nerves (1994) Textbook of Pain, pp. 79-100. , P.D. Wall, & R. Melzack. Edinburgh: Churchill Livingstone
dc.descriptionLane, D.A., Lindahl, U., (1989) Heparin: Chemical and Biological Properties, Clinical Application, , London: Edward Arnold
dc.descriptionDíaz, C., Gutiérrez, J.M., Lomonte, B., Núñez, J., P-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities (1993) Toxicon, 31 (9), pp. 1202-1206
dc.descriptionDíaz-Oreiro, C., Gutiérrez, J.M., Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: Effects on enzymatic and pharmacological properties (1997) Toxicon, 35 (2), pp. 241-252
dc.descriptionDickenson, A.H., Sullivan, A.F., Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation (1987) Neuropharmacology, 26, pp. 1235-1238
dc.descriptionDinarello, C.A., Cytokines as mediators in the pathogenesis of septic shock (1996) Curr. Top. Microbiol. Immunol., 216, pp. 133-165
dc.descriptionDouglas, W.W., Polypeptides-angiotensin, plasma kinins, and others vasoactive agents
dc.descriptionProstaglandins (1970) The Pharmacological Basis of Therapeutics Fourth Ed., pp. 663-676. , L.S. Goodman, & A. Gilman. London: Coller Macmillan
dc.descriptionDray, A., Inflammatory mediators of pain (1995) Br. J. Anaesth., 75, pp. 125-131
dc.descriptionDray, A., The pharmacology of pain (1997) Handbook of Experimental Pharmacology, pp. 21-41. , A. Dickenson, & J.-M. Besson. Berlin: Springer
dc.descriptionDray, A., Perkins, M., Bradykinin and inflammatory pain (1993) Trends Neurosci., 16, pp. 99-104
dc.descriptionDray, A., Urban, L., Dickenson, A., Pharmacology of chronic pain (1994) TIPS, 15, pp. 190-197
dc.descriptionLevine, J.D., Field, H.L., Basbaum, A.I., Peptides and the primary afferent nociceptor (1993) J. Neurosci., 13, pp. 2273-2286
dc.descriptionDua, R., Cho, W., Inhibition of human secretory class II phospholipase A2 by heparin (1994) Eur. J. Biochem., 221, pp. 481-490
dc.descriptionEngland, S., Bevian, S., Dougherty, R.J., PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase a cascade (1996) J. Physiol. (Lond.), 495, pp. 429-440
dc.descriptionEnnis, M., Pearce, F.L., Weston, P.M., Some studies on the release of histamine from mast cells stimulated with polylysine (1980) Br. J. Pharmacol., 70 (2), pp. 329-334
dc.descriptionErspamer, V., Half a century of comparative research on biogenic amines and active peptides in amphibian skin and molluscan tissues (1984) Comp. Biochem. Physiol., 79, pp. 1-7
dc.descriptionFarmer, S.G., Burch, R.M., Biochemical and molecular pharmacology of kinin receptors (1992) Annu. Rev. Pharmacol. Toxicol., 32, pp. 511-536
dc.descriptionFerreira, S.H., Lorenzetti, B.B., Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception (1995) Neuropharmacology, 33, p. 1479
dc.descriptionFerreira, S.H., Nakamura, M., I, Prostaglandin hyperalgesia, a cAMP/Ca2+dependent process (1979) Prostaglandins, 18, pp. 179-190
dc.descriptionFerreira, S.H., Lorenzetti, B.B., Poole, S., Bradykinin initiates cytokine-mediated inflammatory hyperalgesia (1993) Br. J. Pharmacol., 110, pp. 1227-1231
dc.descriptionFitzgerald, E.M., Okuse, K., Wood, J.N., Dolphin, A.C., Moss, S.J., CAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS (1999) J. Physiol., 516 (PT 2), pp. 433-446
dc.descriptionFock, S., Mense, S., Excitatory effects of 5-hydroxytryptamine, histamine and potassium ions on muscular group IV afferent units: A comparison with bradykinin (1976) Brain Res., 105, pp. 459-469
dc.descriptionLin, Y.H., Lee, S.C., Chang, P.Y., Rajan, P.K., Sue, S.C., Wu, W.G., Heparin binding to cobra basic phospholipase A2 depends on heparin chain length and amino acid specificity (1999) FEBS Lett., 453 (3), pp. 395-399
dc.descriptionFoley, K.M., Inturrisi, C.E., Analgesic drug therapy in cancer pain: Principles and practice (1987) Med. Clin. North. Am., 71, pp. 207-232
dc.descriptionFord-Hutchinson, A.W., Leukotriene B4 in inflammation (1990) Crit. Rev. Immunol., 10, pp. 1-12
dc.descriptionFrancis, B., Gutiérrez, J.M., Lomonte, B., Kaiser, I.I., Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2 (1991) Arch. Biochem. Biophys., 284 (2), pp. 352-359
dc.descriptionFranson, R.C., Saal, J.S., Saal, J.A., Human disc phospholipase A2 is inflammatory (1992) Spine, 17, pp. 129-S132
dc.descriptionFu, Y., Light, A.R., Matsushima, G.K., Maixner, W., Microglial reactions after subcutaneous formalin injection into the rat hind paw (1999) Brain Res., 825, pp. 59-67
dc.descriptionGambero, A., Landucci, E.C., Toyama, M.H., Marangoni, S., Giglio, J.R., Nader, H.B., Dietrich, C.P., Antunes, E., Human neutrophil migration in vitro induced by secretory phospholipases A2: A role for cell surface glycosaminoglycans (2002) Biochem. Pharmacol., 63 (1), pp. 65-72
dc.descriptionGammon, C.M., Allen, A.C., Morell, P., Bradykinin stimulates phosphoinositide hydrolysis and mobilization of arachidonic acid in dorsal root ganglion neurons (1989) J. Neurochem., 53, pp. 95-101
dc.descriptionGarcia-Leme, J., Hammamura, L., Leite, M.P., Rocha Silva, E.M., Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating (1973) Br. J. Pharmacol., 48, pp. 88-96
dc.descriptionGarrison, C.J., Dougherty, P.M., Kajander, K.C., Carlton, S.M., Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury (1991) Brain Res., 565, pp. 1-7
dc.descriptionGeoghegan, P., Angulo, Y., Cangelosi, A., Díaz, M., Lomonte, B., Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarara chica) from Argentina (1999) Toxicon, 37 (12), pp. 1735-1746
dc.descriptionLloret, S., Moreno, J.J., Oedema formation and degranulation of mast cells by phospholipase A 2 purified from porcine pancreas and snake venoms (1993) Toxicon, 31, pp. 949-956
dc.descriptionGillies, G.W., Kenny, G.N., Bullingham, R.E., McArdle, C.S., The morphine sparing effect of ketorolac tromethamine. A study of a new parenteral non-steroidal anti-inflammatory agent after abdominal surgery (1987) Anaesthesia, 42, pp. 727-731
dc.descriptionGold, M.S., Shuster, M.J., Levine, J.D., Characterization of six voltage-gated K+currents in adult rat sensory neurons (1996) J. Neurophysiol., 75, pp. 2629-2646
dc.descriptionGranger, D.N., Kubes, P., The microcirculation and inflammation: Modulation of leukocyte- endothelial cell adhesion (1994) J. Leukoc. Biol., 55, pp. 662-675
dc.descriptionGreenberg, S., Modular components of phagocytosis (1999) J. Leukoc. Biol., 66, pp. 712-717
dc.descriptionGrisham, M.B., Granger, D.N., Lefer, D.J., Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: Relevance to ischemic heart disease (1998) Free Radic. Biol. Med., 25, pp. 404-433
dc.descriptionGronblad, M., Virri, J., Ronkko, S., Kiviranta, I., Vanharanta, H., Seitsalo, S., Rashbaum, R.F., Guyer, R.D., A controlled biochemical and immunohistochemical study of human synovial-type (group II) phospholipase A2 and inflammatory cells in macroscopically normal, degenerated, and herniated human lumbar disc tissues (1996) Spine, 21, pp. 2531-2538
dc.descriptionGutiérrez, J.M., Lomonte, B., Phospholipase A2 myotoxins from Bothrops snake venoms (1995) Toxicon, 33 (11), pp. 1405-1424
dc.descriptionGutiérrez, J.M., Rojas, G., Lomonte, B., Gené, J.A., Cerdas, L., Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom (1986) Comp. Biochem. Physiol., 85, pp. 171-175
dc.descriptionHan, S.K., Kim, K.P., Koduri, R., Bittova, L., Munoz, N.M., Leff, A.R., Wilton, D.C., Cho, W., Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2 (1999) J. Biol. Chem., 274 (17), pp. 11881-11881
dc.descriptionHarris, J.B., Cullen, M.J., Muscle necrosis caused by snake venoms and toxins (1990) Electron Microsci. Rev., 3, pp. 183-211
dc.descriptionLloret, S., Moreno, J.J., Ca2+influx, phosphoinositide hydrolysis, and histamine release induced by lysophosphatidylserine in mast cells (1995) J. Cell. Physiol., 165 (1), pp. 89-95
dc.descriptionHernández, M., Burillo, S.L., Crespo, M.S., Nieto, M.L., Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1 (1998) J. Biol. Chem., 273 (1), pp. 606-612
dc.descriptionHolguin, A., O'Connor, K.A., Hansen, M.K., Milligan, E.D., Cheepsunthorn, P., Bravmann, C., Cochran, K., Watkins, L.R., Nitric oxide mediates HIV-1 gp120-induced spinal proinflammatory cytokine production and low threshold mechanical allodynia (2002) J. Pain, 2, p. 27913
dc.descriptionHomsi-Brandeburgo, M.I., Queiroz, L.S., Santo-Neto, H., Rodrigues-Simioni, L., Giglio, J.R., Fractionation of Bothrops jararacussu snake venom: Partial chemical characterization and biological activity of bothropstoxin (1988) Toxicon, 26, pp. 615-627
dc.descriptionHuwiler, A., Staudt, G., Kramer, R.M., Pfeilschifter, J., Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells (1997) Biochim. Biophys. Acta, 1348 (3), pp. 257-272
dc.descriptionJames, M.J., Penglis, P.S., Caughey, G.E., Demasi, M., Cleland, L.G., Eicosanoid production by human manocytes: Does COX-2 contribute to a self-lomoting inflammatory response? (2001) Inflamm. Res., 50, pp. 249-253
dc.descriptionJoris, I., Majno, G., Corey, E.J., Lewis, R.A., The mechanisms of vascular leakage induced by leukotriene E4: Endothelial contraction (1987) Am. J. Pathol., 126, pp. 19-24
dc.descriptionKanashiro, M.M., De Cassia, M., Escocard, R., Petretski, J.H., Prates, M.V., Alves, E.W., MacHado, O.L., Kipnis, T.L., Biochemical and biological properties of phospholipases A2 from Bothrops atrox snake venom (2002) Biochem. Pharmacol., 64 (7), pp. 1179-1186
dc.descriptionKhasar, S.G., Miao, F.J., Levine, J.D., Inflammation modulates the contribution of receptor-subtypes to bradykinin-induced hyperalgesia in the rat (1995) Neuroscience, 69, pp. 685-690
dc.descriptionKidd, B.L., Urban, L.A., Mechanisms of inflammatory pain (2001) Br. J. Anaesth., 87, pp. 3-11
dc.descriptionKim, K.P., Rafter, J.D., Bittova, L., Han, S.K., Snitko, Y., Munoz, N.M., Leff, A.R., Cho, W., Mechanism of human group V phospholipase A2 (PLA 2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation (2001) J. Biol. Chem., 276 (14), pp. 11126-11134
dc.descriptionLomonte, B., Gutiérrez, J.M., A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo) (1989) Toxicon, 27, pp. 725-733
dc.descriptionKim, Y.J., Kim, K.P., Han, S.K., Munoz, N.M., Zhu, X., Sano, H., Leff, A.R., Cho, W., Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A 2 (2002) J. Biol. Chem., 277 (39), pp. 36479-36488
dc.descriptionKing, A.E., Thompson, S.W., Urban, L., Woolf, C.J., An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice (1988) Neurosci. Lett., 89, pp. 286-292
dc.descriptionKini, R.M., Evans, H.J., A model to explain the pharmacological effects of snake venom phospholipases A2 (1989) Toxicon, 27 (6), pp. 613-635
dc.descriptionKyger, E.M., Franson, R.C., Nonspecific inhibition of enzymes by p-bromophenacyl bromide. Inhibition of human platelet phospholipase C and modification of sulfhydryl groups (1984) Biochim. Biophys. Acta, 794 (1), pp. 96-103
dc.descriptionLam, B.K., Gagnon, L., Austen, K.F., Soberman, R.J., The mechanism of leukotriene B4 export from human polymorphonuclear leucocytes (1990) J. Biol. Chem., 265 (23), pp. 13438-13441
dc.descriptionLanducci, E.C., Castro, R.C., Pereira, M.F., Cintra, A.C., Giglio, J.R., Marangoni, S., Oliveira, B., De Nucci, G., Mast cell degranulation induced by two phospholipase A2 homologues: Dissociation between enzymatic and biological activities (1998) Eur. J. Pharmacol., 343 (2-3), pp. 257-263
dc.descriptionLanducci, E.C., Toyama, M., Marangoni, S., Oliveira, B., Cirino, G., Antunes, E., De Nucci, G., Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2 (2000) Toxicon, 38 (2), pp. 199-208
dc.descriptionLanducci, E.C., De Castro, R.C., Toyama, M., Giglio, J.R., Marangoni, S., De Nucci, G., Antunes, E., Inflammatory oedema induced by the Lys-49 phospholipase A2 homologue piratoxin-I in the rat and rabbit. Effect of polyanions and p-bromophenacyl bromide (2000) Biochem. Pharmacol., 59 (10), pp. 1289-1294
dc.descriptionLomonte, B., Tarkowski, A., Hanson, L.A., Host response to Bothrops asper snake venom. Analysis of edema formation, inflammatory cells, and cytokine release in a mouse model (1993) Inflammation, 17 (2), pp. 93-105
dc.descriptionLomonte, B., Tarkowski, A., Bagge, U., Harson, L.A., Neutralization of the cytosolic and myotoxic activities of phospholipase A2 from Bothrops asper snake venom by glycosaminoglycans of heparin/heparan sulfate family (1994) Biochem. Pharmacol., 47, pp. 1509-1518
dc.descriptionLomonte, B., Moreno, E., Tarkowski, A., Hanson, L.A., MacCarana, M., Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling (1994) J. Biol. Chem., 269 (47), pp. 29867-29873
dc.descriptionLuster, A.D., Chemokines: Chemotactic cytokines that mediate inflammation (1998) N. Engl. J. Med., 338, pp. 436-445
dc.descriptionBesson, J.M., The neurobiology of pain (1999) Lancet, 353, pp. 1610-1615
dc.descriptionMalmstrom, K., Daniels, S., Kotey, P., Seidenberg, B.C., Desjardins, P.J., Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: A randomized, placebo- and active-comparator- controlled clinical trial (1999) Clin. Ther., 21, pp. 1653-1663
dc.descriptionMancuso, L.C., Correa, M.M., Vieira, C.A., Cunha, O.A.B., Lachat, J.J., Selistre, H.S.A., Ownby, C.L., Giglio, J.R., Fractionation of Bothrops pirajai snake venom: Isolation and characterization of piratoxin-I, a new myotoxic protein (1995) Toxicon, 33, pp. 615-626
dc.descriptionMarshall, L.A., Bolognese, B., Roshak, A., Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation (1999) Adv. Exp. Med. Biol., 469, pp. 215-219
dc.descriptionMarshall, J., Krump, E., Lindsay, T., Downey, G., Ford, D.A., Zhu, P., Walker, P., Rubin, B., Involvement of cytosolic phospholipase A2 and secretory phospholipase A2 in arachidonic acid release from human neutrophils (2000) J. Immunol., 164 (4), pp. 2084-2091
dc.descriptionMatzner, O., Devor, M., Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+channels (1994) J. Neurophysiol., 72, pp. 349-359
dc.descriptionMcLean, P.G., Ahluwalia, A., Perretti, M., Association between kinin B1 receptor expression and leukocyte trafficking across mouse mesenteric post-capillary venules (2000) J. Exp. Med., 192, pp. 367-380
dc.descriptionMcMahon, S.B., Lewin, G.R., Wall, P.D., Central hyperexcitability triggered by noxious inputs (1993) Curr. Opin. Neurobiol., 3, pp. 602-610
dc.descriptionMeller, S.T., Thermal and mechanical hyperalgesia. A distinct role for different excitatory amino acid receptors and signal transduction pathways? (1994) APS J., 3, pp. 215-231
dc.descriptionMelo, P.A., Ownby, C.L., Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA 2 myotoxins (1999) Toxicon, 37 (1), pp. 199-215
dc.descriptionMelo, P.A., Homsi-Brandenburgo, M.I., Giglio, J.R., Suarez-Kurtz, G., Antagonism of the myotoxic effects of Bothrops jararacussu venom and bothropstoxin by polyanions (1993) Toxicon, 31, pp. 285-291
dc.relationToxicon
dc.rightsfechado
dc.sourceScopus
dc.titleInflammatory Effects Of Snake Venom Myotoxic Phospholipases A2
dc.typeArtículos de revistas


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