Artículos de revistas
A Novel Sunscreen Agent Having Antimelanoma Activity
Registro en:
Farmaco. , v. 58, n. 11, p. 1163 - 1169, 2003.
0014827X
10.1016/S0014-827X(03)00195-2
2-s2.0-10744232774
Autor
Nogueira M.A.
Magalhaes E.G.
Magalhaes A.F.
Biloti D.N.
Laverde Jr. A.
Pessine F.B.T.
Carvalho J.E.
Kohn L.K.
Antonio M.A.
Marsaioli A.J.
Institución
Resumen
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. 58 11 1163 1169 Van Der Leun, J.C., UV radiation from sunlight: Summary, conclusions and recommendations (1996) J. Photochem. Photobiol. B: Biol., 35, pp. 237-244 Singletary, K., MacDonald, C., Iovinelli, M., Fisher, C., Wallig, M., Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene (1998) Carcinogenesis, 19, pp. 1039-1043 Jackson, K.M., DeLeon, M., Verret, R.C., Harris, B.W., Dibenzoylmethane induces cell cycle deregulation in human prostate cancer cells (2002) Cancer Lett., 178, pp. 161-165 Kligman, L.H., The effects of UVA radiation - Are sunscreens protective enough (1989) J. Toxicol.-Cutan. Ocul. Toxicol., 8, pp. 565-568 Fukai, T., Nishizawa, J., Nomura, T., Five isoprenoid-substituted flavonoids from Glycyrrhiza eurycarpa (1994) Phytochemistry, 35, pp. 515-519 Magalhães, A.F., Tozzi, A.M.A., Magalhães, G.E., Blanco, I.S., Nogueira, M.A., Three dibenzoylmethane derivatives from Lonchocarpus species (1997) Phytochemistry, 46, pp. 1029-1033 Magalhães, A.F., Tozzi, A.M.A., Magalhães, E.G., Nogueira, M.A., Floréz, R.V.J., Ensayos biológicos con extractos obtenidos de raíces de Lonchocarpus latifolius (Willd) D.C. de um nuevo dibenzoilmetano aislado (1998) Rev. Ceres, 45, pp. 351-358 Araújo, A.C.V., Almeida, F.V., Bieber, L.W., The synthesis of malonic esters: A new procedure for a classical reaction (1996) Quim. Nova, 19, pp. 79-81 Biloti, D.N., Reis, M.M., Ferreira, M.M.C., Pessine, F.B.T., Photochemical behavior under UVA radiation of β-cyclodextrin included Parsol ® 1789 with a chemometric approach (1999) J. Mol. Struct., 480-481, pp. 557-561