Artículos de revistas
Enhancement Of Latent Inhibition By Chronic Mild Stress In Rats Submitted To Emotional Response Conditioning
Registro en:
Neural Plasticity. Hindawi Publishing Corporation, v. 10, n. 4, p. 327 - 333, 2003.
20905904
10.1155/NP.2003.327
2-s2.0-3242745106
Autor
Melo L.L.
de Moraes Ferrari E.A.
Teixeira N.A.
Sandner G.
Institución
Resumen
This work evaluated the influence of chronic mild stress on latent inhibition (LI) in rats, using a conditioned emotional response (CER) procedure. Rats were assigned to four groups: a non pre-exposed control group (NPC), a non pre-exposed stressed group (NPS), a pre-exposed control group (PC), and a pre-exposed stressed group (PS). Stressed animals were submitted to a chronic mild stress (CMS) regimen for three weeks. The off-baseline conditioned emotional response procedure had four phases: licking response training, tone-shock conditioning, retraining, and testing. Conditioning consisted of 2 tone (30 s) and shock (0.5 s) associations. Tone-shock conditioning evidenced by NPS and NPC groups suggests that stress did not interfere with the expression of a conditioned emotional response. Pre-exposure was carried out using 6 tones (30 s) during 2 sessions before conditioning. Prior exposure to the tone resulted in a decrease in learning that was greater in stressed animals. 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