Artículos de revistas
Costimulatory Molecule Expression On Leukocytes From Mice With Experimental Autoimmune Encephalomyelitis Treated With Ifn-β
Registro en:
Journal Of Interferon And Cytokine Research. , v. 23, n. 6, p. 293 - 298, 2003.
10799907
10.1089/107999003766628133
2-s2.0-0038544597
Autor
Hallal D.E.M.
Farias A.S.
Oliveira E.C.
Diaz-Bardales B.M.
Brandao C.O.
Protti G.G.
Pereira F.G.
Metze I.L.
Santos L.M.B.
Institución
Resumen
Interferon-β (IFN-β) is of benefit in the treatment of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), but the mechanisms by which it exerts this beneficial effect remain uncertain. The present data demonstrate that IFN-β therapy impairs the proliferative response to concanavalin A (ConA) and myelin basic protein (MBP), decreases expression of the CD80 molecule on leukocytes of treated mice, and may thereby impede the Th1 cell activation-promoting anergy in EAE. Moreover, IFN-β therapy increases expression of the CTLA4 molecule, which induces a counterregulatory Th2 response. 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