Artículos de revistas
An easy and efficient method to produce gamma-amino alcohols by reduction of beta-enamino ketones
Registro en:
Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 15, n. 6, p. 971-975, 2004.
0103-5053
S0103-50532004000600027
10.1590/S0103-50532004000600027
Autor
Harris, Maria Inês N. C.
Braga, Antonio C. H.
Institución
Resumen
Reduction of beta-enamino ketones 2 with NaBH4 in glacial acetic acid gave gamma-amino alcohols 1 in 70% to 98% yield with diastereomeric excesses, preferentially the syn product, from 44% to 90%. The stereochemistry of these compounds was confirmed by analysis of their tetrahydro-1,3-oxazine derivatives 3. A redução de beta-enamino cetonas 2 com NaBH4 em ácido acético glacial produziu gama-amino álcoois 1 em 70% a 98% de rendimento, com excessos diastereoméricos, preferencialmente o produto syn, de 44% a 90%. A estereoquímica desses compostos foi confirmada pela análise de seus derivados tetraidro-1,3-oxazinas 3. 971 975