Artículos de revistas
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
Local anesthetics: interaction with biological membranes and with the voltage-gated sodium channel
Química Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1775-1783, 2008.
Araujo, Daniele Ribeiro de
Paula, Eneida de
Fraceto, Leonardo Fernandes
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.17751783Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)