Brasil | Artículos de revistas
dc.creatorBenites, B.D.
dc.creatorFattori, A.
dc.creatorHackel, C.
dc.creatorLorand-Metze, I.
dc.creatorDe Souza, C.A.
dc.creatorSchulz, E.
dc.creatorCosta, F.F.
dc.creatorSaad, S.T.O.
dc.date2008-07-01
dc.date2014-07-18T13:28:45Z
dc.date2015-11-26T11:39:42Z
dc.date2014-07-18T13:28:45Z
dc.date2015-11-26T11:39:42Z
dc.date.accessioned2018-03-28T20:43:06Z
dc.date.available2018-03-28T20:43:06Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 571-578, 2008.
dc.identifier0100-879X
dc.identifierS0100-879X2008000700004
dc.identifier10.1590/S0100-879X2008000700004
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008000700004
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000700004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/31242
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/31242
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1234281
dc.descriptionApoptotic protease activating factor 1 (APAF-1) has a critical role in the regulation of apoptosis. In the present study, the mRNA expression analysis of different APAF-1 transcripts (APAF-1S, APAF-1LC, APAF-1LN, and APAF-1XL) was analyzed in bone marrow samples from 37 patients with acute myeloid leukemia (newly diagnosed, with no previous treatment). APAF-1XL and APAF-1LN transcripts (with and without an extra WD-40 repeat region, respectively) were detected in all samples, although the major form expressed was APAF-1XL in 65% of the samples (group 1), while 35% of the samples expressed primarily APAF-1LN (group 2). Only 46% of the patients presented complete remission in response to remission induction therapy (represented by less than 5% marrow blasts and hematological recovery), all but 2 cases being from group 1, 21.6% did not attain complete remission (only 1 case from group 1), and 32.4% of the patients died early. Lower expression of APAF-1XL (APAF-1XL/APAF-1LN ratio <1.2) was associated with a poor response to therapy (P = 0.0005, Fisher exact test). Both groups showed similar characteristics regarding white blood cell counts, cytogenetic data or presence of gene rearrangements associated with good prognosis as AML1-ETO, CBFB-MYH11 and PML/RARA. Since it has been shown that only the isoforms with the extra WD-40 repeat region activate procaspase-9, we suggest that low procaspase-9 activation may also be involved in the deregulation of apoptosis and chemotherapy resistance in acute myeloid leukemia.
dc.description571
dc.description578
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectAPAF-1
dc.subjectAcute myeloid leukemia
dc.subjectApoptosis
dc.subjectChemotherapy resistance
dc.titleLow expression of APAF-1XL in acute myeloid leukemia may be associated with the failure of remission induction therapy
dc.typeArtículos de revistas


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